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Human Polyclonal CFL1/2 Primary Antibody for IF, IHC - ABIN363074
Chen, Cizeau, Vande Velde, Park, Bozek, Bolton, Shi, Dubik, Greenberg: Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. in The Journal of biological chemistry 1999
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Human Polyclonal CFL1/2 Primary Antibody for IHC - ABIN362442
Arber, Barbayannis, Hanser, Schneider, Stanyon, Bernard, Caroni: Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. in Nature 1998
Show all 4 Pubmed References
Cofilin 1 expression may be involved in the pathophysiology of bronchopulmonary dysplasia via dysregulation of actin binding proteins
In conclusion, deregulation of cytoskeleton dynamics through TESK1/CFL1 pathway underlies epithelial intestinal dysfunction in the small bowel mucosa of diarrhea-predominant irritable bowel syndrome, particularly in female patients.
High CFL1 expression is associated with malignant pancreatic lesions.
High CFL1 expression is associated with epithelial-mesenchymal transition of gastric cancer.
Cofilin-1 plays a dominant role in angiotensin-(1-7)-induced G0/G1 arrest and autophagy to maintain cellular homeostasis in human aortic endothelial cells
NKCC1 not only controls cell volume and Cl- concentration, but it can also regulate the actin cytoskeleton through Cofilin 1.
The enhancement of cancer cells invasion is dependent on CFL1, a known regulator of invadopodia maturation.
The present study demonstrates that miR-145 plays an important role in inhibiting cell migration by directly targeting PAK4, and identifies miR-145-PAK4-LIMK1-cofilin as a novel regulatory pathway that contributed to colorectal cancer metastasis.
D44 and RHOA are required for CFL1 phosphorylation and cell migration induced by CD74 in breast cancer cells.
Our results revealed that CKS1 is involved in normal glutamatergic synapse development and dendritic spine maturation in adult hippocampus through modulating p27 stability.
Our study indicates that Cofilin 1 holds an important position in the development and progression of human bladder cancer
Results suggest that the immune-complex (IC) of cofilin-1 in sera is a potentially attractive serum biomarker for the prognosis of pancreatic ductal adenocarcinoma (PDAC).
High cofilin expression is associated with adrenocortical tumor.
In advance urothelial cancer, overexpression of nuclear cofilin correlates with bladder cancer progression.
Report structural basis for noncanonical substrate recognition of cofilin-1/LIMK1 to regulation actin cytoskeleton dynamics.
STMN1,COF1 and PAIRBP1 thus represent proteins associated with proliferative and aggressive tumors of high grades, while TSP2 and POSTN were connected to low grade tumors with better prognosis
We observed marked increases in LIM kinase 2 (LIMK2) and cofilin 1 (CFL1) gene expressions in metabolic syndrome patients.
Therefore, miR-138/LIMK1/cofilin may be considered a potential therapeutic target for the treatment of non-small cell lung cancer
These findings indicate that inhibition of the Rac1WAVE2Arp2/3 signaling pathway may promote radiosensitivity, which may partially result from the downregulation of CFL1 in U251 human glioma cells.
The present findings demonstrated that the anticancer effect of docetaxel induces the apoptosis of prostate cancer via the suppression of the cofilin1 and paxillin signaling pathways, which will assist in setting a stage for the clinical treatment of prostate cancer.
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.
18 kDa phosphoprotein
, cofilin, non-muscle isoform