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we uncovered cell state plasticity and adhesion dynamics regulated by Ror2 (show ROR2 Proteins), which influenced Ras Homology Family Member A (show CXCL14 Proteins) (RhoA (show RHOA Proteins)) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1 (show ROCK1 Proteins)) activity downstream of Dishevelled-2 (Dvl2).
Epsins are required for Dishevelled stability and Wnt (show WNT2 Proteins) signalling activation in colon cancer development.
Dpr1 (show DACT1 Proteins) promotes the ubiquitination of Dvl2 by pVHL (show VHL Proteins) and mediates the protein aggregate-elicited autophagy initiation
Dvl2 binds to Rab35 (show RAB35 Proteins) and activation is required for MCF-7 cell migration
Dvl-2 and Dvl-3 (show DVL3 Proteins) have a widespread distribution in both the olfactory epithelium and olfactory bulb
Dullard (show DULLARD Proteins) may play a role in the fine-tuning of WNT (show WNT2 Proteins) signalling activity by modulating the expression of ligands/antagonists and the availability of Dvl2 protein during specification of the germ cell lineage.
loss of Dvl2 function in Vangl2(Lp (show VANGL2 Proteins)/+) embryos did not exacerbate the Vangl2(Lp (show VANGL2 Proteins)/+) neuronal migration phenotype
Identification of a novel Wnt5a-CK1varepsilon-Dvl2-Plk1-mediated primary cilia disassembly pathway.
These findings suggest that Wnt5a (show WNT5A Proteins)-Ror-Dishevelled signaling constitutes a core noncanonical Wnt (show WNT2 Proteins) pathway that is conserved through evolution and is crucial during embryonic development.
Dvl2 has an inhibitory role in myogenesis and Stau1 (show STAU1 Proteins) coordinates myogenesis through the regulation of Dvl2 mRNA.
Dvl2 could play a part in epithelial ovarian cancer progression and might be an independent prognostic factor. Additionally, it might be a prospective therapeutic target in the treatment of EOC.
Our findings reveal an underappreciated role of Dvl2 in regulating inflammation and rheumatoid arthritis-fibroblast-like synoviocyte apoptosis
two mutually exclusive functions of the DEP domain in Wnt (show WNT2 Proteins) signal transduction - binding to Frizzled to recruit Dishevelled to the receptor complex, is reported.
inhibition of DVL2 can sensitize cisplatin-resistant lung cancer cells through down-regulating Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
Data show that RAP1B (show RAP1B Proteins) expression was up-regulated in esophageal squamous cell carcinoma (ESCC) clinical samples and RAP1B (show RAP1B Proteins) interacted with DVL2 and activated Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
ESCC patients with high Dvl2 expression had worse prognoses and multivariate analysis indicated that Dvl2 was an independent risk factor for ESCC patients' survival. Our clinical data indicated that Dvl2 contribute to the malignant progression of ESCC and might be a prognostic biomarker.
Data show that dishevelled proteins DVL1 (show DVL1 Proteins), 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).
The secreted frizzled-related protein (show SFRP2 Proteins) and disheveled protein family members appear to be actively involved in the pathogenesis of primary testicular germ cell tumors.
In pancreatic cancer cells, AF6 is expressed at reduced levels, causing Dvl2 to be upregulated and available to bind and enhance FOXE1 (show FOXE1 Proteins)-induced trans-activation of Snail (show SNAI1 Proteins), which promotes proliferation and metastasis.
CapZIP (show RCSD1 Proteins), which has been shown to regulate ciliogenesis, is an ERK7 (show MAPK15 Proteins) substrate, and that Dishevelled, which has also been shown to regulate ciliogenesis, facilitates ERK7 (show MAPK15 Proteins) phosphorylation of CapZIP (show RCSD1 Proteins) through binding to both ERK7 (show MAPK15 Proteins) and CapZIP (show RCSD1 Proteins).
Different Dvl proteins (Dvl1 (show DVL1 Proteins), Dvl2, Dvl3 (show DVL3 Proteins)) and the composition of dishevelled-beta-arrestin protein complexes contribute to the specific activation of individual branches of Wnt (show WNT2 Proteins) signaling in Xenopus gastrulation.
these findings suggest that regulation of Dvl protein levels by NEDD4L (show NEDD4L Proteins) is essential for convergent extension during early Xenopus embryogenesis.
findings reveal that, in response to Wnt (show WNT2 Proteins) signalling, Dishevelled inhibits CSL (show SMPX Proteins) transcription factors to regulate Notch (show NOTCH1 Proteins) signalling and cell-fate decisions in vivo
Data show that maternal Dvl2 and 3 are required for convergence extension movements downstream of the dorsally localized signaling pathway activated by Xnr3, but not downstream of the pathway activated by activin.
The archenteron elongation is independent of Xdsh signaling, especially during the second half of gastrulation.
Subcellular localization is insufficient to account for the pathway specificity of Dishevelled in the canonical Wnt (show WNT2 Proteins) versus PCP (show PRCP Proteins) signaling cascades.
both Lgl and Dsh are required for normal apical-basal polarity of Xenopus ectodermal cells
Gain- and loss-of-function experiments suggest that Xdsh associates with ephrinB1 (show EFNB1 Proteins) and mediates ephrinB1 (show EFNB1 Proteins) signalling through downstream members of the PCP (show PRCP Proteins) pathway during eye field formation.
The direct interaction of Dvl2 with AP-2 is important for Frizzled internalization and Frizzled/planar cell polarity signaling.
demonstrate that during early zebrafish development Nkd1 (show NKD1 Proteins) does not alter either endogenous or exogenous levels of Dvl2
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
DSH homolog 2
, dishevelled, dsh homolog 2
, segment polarity protein dishevelled homolog DVL-2
, dishevelled 2
, dishevelled, dsh homolog 2 (Drosophila)
, dishevelled 2 (homologous to Drosophila dsh)
, dishevelled homolog
, dishevelled 2, dsh homolog