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This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.
, protein reduced scale-3
, tumor necrosis factor receptor superfamily member EDAR
, ectodysplasin receptor
, ectodysplasin A receptor
, tumor necrosis factor receptor superfamily member EDAR-like
, EDA-A1 receptor
, anhidrotic ectodysplasin receptor 1
, downless homolog
, downless, mouse, homolog of
, ectodermal dysplasia receptor
, ectodysplasin 1, anhidrotic receptor
, ectodysplasin-A receptor
, ectodysplasin A1 receptor