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Human Monoclonal FAP Primary Antibody for IP, ELISA - ABIN560844
Wang, Yao, Nadvi, Osborne, McCaughan, Gorrell: Fibroblast activation protein and chronic liver disease. in Frontiers in bioscience : a journal and virtual library 2007
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Mouse (Murine) Polyclonal FAP Primary Antibody for WB - ABIN1881337
Wen, Wang, Ma, Li, Zhou, Mu, Leng, Shi, Li, Wei: Immunotherapy targeting fibroblast activation protein inhibits tumor growth and increases survival in a murine colon cancer model. in Cancer science 2010
Show all 3 Pubmed References
Human Polyclonal FAP Primary Antibody for IF (p) - ABIN896768
Evrard, Lecce, Michelis, Nomura-Kitabayashi, Pandey, Purushothaman, dEscamard, Li, Hadri, Fujitani, Moreno, Benard, Rimmele, Cohain, Mecham, Randolph, Nabel, Hajjar, Fuster, Boehm, Kovacic: Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability. in Nature communications 2016
Show all 2 Pubmed References
Human Polyclonal FAP Primary Antibody for IHC (p) - ABIN2473589
Kelly: Fibroblast activation protein-alpha and dipeptidyl peptidase IV (CD26): cell-surface proteases that activate cell signaling and are potential targets for cancer therapy. in Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2005
Human Polyclonal FAP Primary Antibody for IHC (p) - ABIN5577905
Zhai, Zhang, Wang, Lu, Liu, Yu, Weng, Ding, Zhu, Shi: Growth differentiation factor 15 contributes to cancer-associated fibroblasts-mediated chemo-protection of AML cells. in Journal of experimental & clinical cancer research : CR 2016
Human Polyclonal FAP Primary Antibody for IF (p), IHC (p) - ABIN714311
Zhang, Jiang, Ling, Cao, Zhao, Tuo, She, Shen, Jiang, Hu, Pang: Enhanced Antitumor Activity of EGFP-EGF1-Conjugated Nanoparticles by a Multitargeting Strategy. in ACS applied materials & interfaces 2016
Human Polyclonal FAP Primary Antibody for IHC (p) - ABIN252929
Herrera, Herrera, Alba-Castellón, Silva, García, Loubat-Casanovas, Alvarez-Cienfuegos, Miguel García, Rodriguez, Gil, Ma Jesús Citores, Ma Jesús Larriba, Ignacio Casal, de Herreros, Bonilla, Peña: Protumorigenic effects of Snail-expression fibroblasts on colon cancer cells. in International journal of cancer 2014
Human Polyclonal FAP Primary Antibody for IHC (p) - ABIN4311688
Herrera, Herrera, Domínguez, Silva, García, García, Gómez, Soldevilla, Muñoz, Provencio, Campos-Martin, García de Herreros, Casal, Bonilla, Peña: Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients. in Cancer science 2013
the uptake of the tracer in the joints reflects increased FAP expression during subclinical synovitis and that these joints will show symptoms of inflammation upon disease progression
Adora2B (show ADORA2B Antibodies) stimulation promotes FGF2 (show FGF2 Antibodies) and CXCL12 (show CXCL12 Antibodies) expression in FAP-positive melanoma-associated (show ZNF654 Antibodies) fibroblasts, contributing to the creation of a tumor-promoting microenvironment.
There was no evidence of compensatory upregulation of other DPP4 (show DPP4 Antibodies) family members in influenza-infected FAP-deficient mice. FAP appears to be dispensable in anti-influenza adaptive immunity.
FAP-STAT3 (show STAT3 Antibodies)-CCL2 (show CCL2 Antibodies) signaling in Cancer-associated fibroblasts (CAF (show LAMA2 Antibodies)) was sufficient to program an inflammatory component of the tumor microenvironment, which may have particular significance in desmoplasia-associated cancers.
Taken together, our study suggested that high FAP expression in CAFs (show TBX1 Antibodies) is one reason leading to immune checkpoint blockades resistance in CRC (show SCRIB Antibodies) patients and FAP is an optional target for reversing immune checkpoint blockades resistance.
FAP-vaccinated mice also treated with Cyclophosphamide chemotherapy showed a marked suppression of tumor growth (inhibition ratio =80%) and a prolongation of survival time.
In two different models of pulmonary fibrosis, intratracheal bleomycin instillation and thoracic irradiation, the study finds increased mortality and increased lung fibrosis in FAP-deficient mice compared with wild-type mice.
Mouse FGF-21 (show FGF21 Antibodies), however, lacks the FAP cleavage site and is not cleaved by FAP.
Data indicate that indolamine-2,3-dioxygenase (IDO (show IDO1 Antibodies)) and Fibroblast activation protein alpha (FAPalpha) were detectable in B16 melanoma tumor-bearing mice.
A transgenic mouse model for pulmonary fibrosis was generated. After bleomycin induction, luciferase cDNA under the control of the FAPa promoter presents strong luminescence in the lungs especially; the expression level reflects the degree of the disease.
Soluble form of a seprase activity is detected in bovine serum
We clearly show an association between FAPalpha and chondrocytes in the context of cartilage degradation. (Fibroblast activation protein alpha)
Mounting evidence supported that miR (show MLXIP Antibodies)-30a-5p directly targetted FAP and suppressed its expression in oral cavity cancer cells (OSCCs). By suppressing FAP expression, miR (show MLXIP Antibodies)-30a-5p significantly inhibited cell propagation, migration, and invasion. Therefore, miR (show MLXIP Antibodies)-30a-5p might be a new therapeutic target for oral cancer treatment.
These results revealed that FAPalpha promoted the growth, adhesion and migration of lung squamous cell carcinoma cells. In addition, FAPalpha regulated lung cancer cell function, potentially via the PI3K (show PIK3CA Antibodies) and SHH (show SHH Antibodies) pathways. Further investigations are required to examine the role of FAPalpha in lung AC cells.
Several isoforms of DPP-IV (show DPP4 Antibodies) and FAP are present in glioblastoma tissue. The absence of alkaline isoforms of both enzymes in glioma cell lines however suggests that isoforms from other, most likely stromal, cell types contribute to the overall pattern seen in glioblastoma tissues.
The predictors for FAP occurrence among desmoid tumor patients are large tumor size, intra-abdominal location, multiple tumors, and patient's young age.
This evidence highly suggested that FAP is a potential prognosticator of GC patients and a target for synergizing with other treatments, especially immune checkpoint blockades in GC.
Mutations to predicted TM interfacial residues (G10L (show BUD31 Antibodies), S14L, and A18L) comprising a small-X3-small motif reduced FAP TM-CYTO dimerization relative to wild type. Predicted off-interface residues showed no significant change from wild type. The interfacial TM residue G10L (show BUD31 Antibodies) decreased FAP endopeptidase activity more than 25%, and reduced cell-surface versus intracellular expression relative to interfacial S14L and A18L.
proCOL11A1, fibroblast-activated protein, secreted protein acidic and rich in cysteine (show SPARC Antibodies), and periostin (show POSTN Antibodies) expression was significantly increased in the intratumoral stroma of pancreatic ductal adenocarcinomas compared to paired non-neoplastic pancreata
Circulating FAP activity and antigen levels correlate strongly when measured in liver disease and coronary heart disease.
Fibroblast activation protein (P=.00117) was stronger than grade and stage in predicting clinical aggressiveness in clear cell renal cell carcinoma (show MOK Antibodies).
expression of FAP in primary tumors and in their metastases was associated both with synchronous metastases and also with metastases to the lymph nodes
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.
fibroblast activation protein alpha
, integral membrane serine protease
, fibroblast activation protein, alpha
, fibroblast activation protein, alpha subunit
, gene 13
, 170 kDa melanoma membrane-bound gelatinase
, prolyl endopeptidase FAP