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report association of APOE (show APOE Proteins) and TOMM40 (show TOMM40 Proteins) with behavioural variant frontotemporal dementia, and ARHGAP35 and SERPINA1 (show SERPINA1 Proteins) with progressive non-fluent aphasia.
interaction involves the first FF motif of p190A and the winged helix/PCI (show SERPINA5 Proteins) domain of eIF3A (show EIF6 Proteins), is enhanced by serum stimulation and reduced by phosphatase treatment
these data demonstrate that a complex of p190RhoGAP-A and anillin (show ANLN Proteins) modulates RhoA (show RHOA Proteins)-GTP (show AK3 Proteins) levels in the cytokinetic furrow to ensure progression of cytokinesis.
These results place Blk (show BLK Proteins) upstream of the p190RhoGAP-RhoA (show RHOA Proteins) pathway in Galpha13 (show GNA13 Proteins)-activated cells, overall representing an opposing signaling module during CXCL12 (show CXCL12 Proteins)-triggered invasion.
ARHGAP35 rs1052667 polymorphism was an independent prognostic factor influencing the survival of osteosarcoma.
GRF-1 expression may modify osteosarcoma prognosis and may be a potential tumor therapeutic target.
A ubiquitous binding partner of p190RhoGAP, p120RasGAP (RasGAP (show RASA1 Proteins)), is expressed in much lower levels in DKO4 cells compared to DLD1, and this expression is regulated by KRAS.
Overexpression of p190 (show CNTNAP1 Proteins) mRNA associated with lung adenocarcinoma.
These data suggest that the interaction of human papillomavirus E7 with p190 dysregulates this GTPase activating protein and alters the actin cytoskeleton.
RhoA (show RHOA Proteins) is down-regulated at cell-cell contacts via p190RhoGAP-B in response to tensional homeostasis.
p190A acts as a modulator of Rho GTPases in a localized area around the cilia to permit the dynamic actin rearrangement required for cilia elongation.
The cellular RacGAP activity of p190RhoGAP requires an intact polybasic region adjacent to the GAP domain whereas the RhoGAP (show ARHGAP1 Proteins) activity is inhibited by the same domain.
study demonstrates that the epidermal growth factor receptor (EGFR (show EGFR Proteins)) cooperates with beta3 integrin (show ITGB3 Proteins) to regulate p190RhoGAP activity in mammary gland epithelial cells
p190RhoGAP links integrins and caveolin-1 (show CAV1 Proteins)/caveolae to RhoA (show RHOA Proteins) in a mechanotransduction cascade that participates in endothelial adaptation to flow.
In a novel knockout mouse strain p190RhoGAP does not play a major, indispensable role in integrin signaling of neutrophils.
Cdh1 (show CDH1 Proteins) formed a physical complex with p190 (show CNTNAP1 Proteins) and stimulated the efficient ubiquitination of p190 (show CNTNAP1 Proteins), both in in vitro and in vivo.
identified the serum-responsive transcriptional regulator TFII-I (show GTF2I Proteins) as a specific interactor with the p190 RhoGAP FF domains
p190 transiently associates with plexins, and its RhoGAP activity is increased in response to semaphorin stimulation. We conclude that p190-RhoGAP is crucially involved in semaphorin signalling to the actin cytoskeleton, via interaction with plexins.
FAK (show PTK2 Proteins)-induced down-modulation of RhoA (show RHOA Proteins) activity via p190RhoGAP is a crucial step in signaling endothelial barrier restoration after increased endothelial permeability
Rac (show AKT1 Proteins) activation links diverse signaling systems to adherens junction assembly by controlling transient p190RhoGAP interactions with p120 (show CTNND1 Proteins) and localized inhibition of Rho.
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.
glucocorticoid receptor DNA binding factor 1
, glucocorticoid receptor DNA-binding factor 1
, glucocorticoid receptor repression factor 1
, rho GAP p190A
, rho GTPase-activating protein 35
, P190 RhoGAP
, GAP-associated protein p190
, Rho GTPase activating protein 35 L homeolog
, rho GTPase activating protein 35 L homeolog