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Hectd1 regulates the protein level of IQGAP1 through ubiquitination.
Hectd1 is required for development of the labyrinthine zone of the mouse placenta.
Hectd1 is required for development of multiple cell types within the junctional zone of the placenta.
Hectd1 is a functional ubiquitin ligase (show RNF123 Proteins) and that one of its substrates is Hsp90 (show HSP90 Proteins), a chaperone protein with both intra- and extracellular clients.
Hectd1 function is required at a critical threshold for neural tube closure.
our high-resolution structures show a new fold composed of five small helices where H3 and H4 are tilted (show OTOP1 Proteins) in a novel arrangement; we call this fold the Basic Tilted (show OTOP1 Proteins) Helix Bundle (BTHB) domain.
HectD1 promotes the APC (show APC Proteins)-Axin (show AXIN1 Proteins) interaction to negatively regulate Wnt (show WNT2 Proteins) signaling.
Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity).
HECT domain containing 1
, E3 ubiquitin-protein ligase HECTD1
, HECT domain-containing protein 1
, protein open mind
, E3 ligase for inhibin receptor