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A total of three nonsynonymous mutations (p.Gln240Glu, p.Ser298Asn and p.Ala381Glu) of the IRX1 (show IRX3 Proteins) gene were verified in 215 nonsyndromic congenital heart disease patients.
this is the first genome-wide association study of Rheumatoid Factor positivity in Rheumatoid Arthritis. Variation at the IRX1 (show IRX3 Proteins) locus on chromosome 5p15.3 is associated with the presence of Rheumatoid Factor. Our findings indicate that IRX1 (show IRX3 Proteins) and HLA-DRB1 (show HLA-DRB1 Proteins) are the strongest genetic factors for Rheumatoid Factor production in Rheumatoid Arthritis.
In osteosarcoma cells and lines, IRX1 (show IRX3 Proteins) overexpression was associated with hypomethylation of its own promoter. Experimental modulation in cell lines altered migration, invasion, and resistance to anoikis in vitro, and influenced lung metastasis in mice.
Findings suggest that methylation-associated down-regulation of EBF3 (show MAPRE3 Proteins) and IRX1 (show IRX3 Proteins) genes may play an important role in a pathogenic effect of TGF-beta (show TGFB1 Proteins) on RASFs.
Helicobacter pylori infection contributes to IRX1 (show IRX3 Proteins) promoter methylation in gastric mucosa.
enforcing IRX1 (show IRX3 Proteins) expression effectively suppresses peritoneal spreading and pulmonary metastasis via anti-angiogenesis and anti-VM mechanisms, in addition to previously found cell growth and invasion.
Homeobox (show Lbx1 Proteins) gene IRX1 (show IRX3 Proteins) is a tumor suppressor gene in gastric carcinoma.
Results verify IRX1 (show IRX3 Proteins), EBF3 (show MAPRE3 Proteins), SLC5A8, SEPT9 (show SEPT9 Proteins), and FUSSEL18 as valid methylation markers in two separate sets of HNSCC specimens; also preliminarily show a trend between HPV16 positivity and target gene hypermethylation of IRX1 (show IRX3 Proteins), EBF3 (show MAPRE3 Proteins), SLC5A8, and SEPT9 (show SEPT9 Proteins).
Frequent methylation of IRX1 (show IRX3 Proteins) gene is associated with head and neck squamous cell carcinoma
Irx1 regulates Foxj1 (show FOXJ1 Proteins) and Sox9 (show SOX9 Proteins) to control cell differentiation during development.
This homeobox protein (show HOXA1 Proteins) is expressed during early lung development.
This homeobox protein (show HOXA1 Proteins) is expressed during digit development and is an early marker for this development.
Observations suggest that Irx2 (show IRX2 Proteins) functions downstream of irx1a to control shh (show SHH Proteins) expression in the retina. Study proposed a novel transcriptional cascade of ath5 (show ATOH7 Proteins)-irx1a-irx2a in the regulation of hedgehog (show SHH Proteins) waves during vertebrate retinal development.
Data revealed that expression of DNA binding inhibitor 3, early B cell factor 2, Ebf3, Iroquois related homeobox 1, Kruppel-like factor 7 , mab-21-like 1 , fatty acid binding protein 7 and stathmin-like 4,were enriched in the diencephalon of zebrafish.
Our results reveal a role for Iroquois genes in controlling hedgehog (show SHH Proteins) expression during vertebrate retinogenesis.
irx1a is not required for the initial specification but it is required for the complete differentiation of 5HT (show DDC Proteins) neurons
This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13.
homeodomain protein IRXA1
, iroquois homeobox protein 1
, iroquois-class homeodomain protein IRX-1
, iroquois homologue-1
, iroquois homeobox 1
, iroquois-class homeodomain protein irx-1
, Iroquois related homeobox 1
, Iroquois homeobox protein 1-A
, homeobox Iro protein
, iroquois-class homeodomain protein irx-1-A
, LOW QUALITY PROTEIN: iroquois-class homeodomain protein IRX-1