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Increased adipocyte-specific expression of IRX3 correlates with the presence of the FTO obesity risk haplotype in lean children, whereas it was unaffected by risk variants in obese peers. IRX3 expression in adipocytes was significantly related to adipocyte hypertrophy.
the association between FTO and obesity appears to be due to its influence on expression of IRX3 [Figure 1]. Genetic studies indicated FTO as an important gene for obesity risk in various populations but the recent developments suggest that obesity-associated FTO SNPs have long-range interactions with IRX3.
Downregulation of miR (show MLXIP Proteins)-377 may contribute to the upregulation of IRX3 in HCC (show FAM126A Proteins).
This is the first study to reveal that genetic variants of both FTO and IRX3 genes are in high linkage disequilibrium (LD) and are associated with obesity risk in North Indians.
Strategies to pharmacologically regulate Irx3 function in adult endothelial cells may provide new therapies for angiogenesis.
data suggest that IRX3 is a functional long-range target of obesity-associated variants within FTO (show FTO Proteins) and represents a novel determinant of body mass and composition
IRX3 function may have a direct functional relationship to both obesity and type 2 diabetes.
Irx3 is necessary for the postnatal maturation of the VCS (show EDC4 Proteins), possibly via its interactions with Tbx5 (show TBX5 Proteins) and Nkx2.5 (show NKX2-5 Proteins).
Irx3 and Irx5 (Irx3/5) are essential in the initiating limb bud to specify progenitors of the femur, tibia, and digit 1.
postnatal Irx3 activity can be repressed by Irx5 (show IRX5 Proteins)
Irx3 is critical for efficient conduction in this specialized tissue by antithetically regulating two gap junction-forming connexins
Irx3 signal is restricted to the somatic cell component of XX gonads and is present at a discreet period of ovarian development that ends at birth.
barH-like homeobox-2 (show BARHL2 Proteins) gene barhl2 (show BARHL2 Proteins) acts downstream of orthodentricle-2 and together with iroquois-3 in establishment of the caudal forebrain signaling center induced by Sonic Hedgehog (show SHH Proteins)
Irx3 is transcriptionally induced by the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway during anteroposterior patterning of the neural axis.
Irx3 is the first gene known to be necessary and sufficient to specify nephron segment fate in vivo.
Data show that human fat mass and obesity associated protein FTO (show FTO Proteins) BAC:GFP transgenic zebrafish larvae expressed GFP in the the posterior hypothalamus and the anterior brainstem, which are also expression domains of zebrafish protein irx3a.
Olig2 (show OLIG2 Proteins) is required for repression of iro3 expression in the progenitor domain of ventral spinal cord
IRX3 is a member of the Iroquois homeobox gene family (see IRX1\; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998
homeodomain protein IRXB3
, iroquois homeobox protein 6
, iroquois homeobox protein 7
, iroquois-class homeodomain protein IRX-6
, homeodomain protein IRXB1
, iroquois homeobox protein 3
, iroquois-class homeodomain protein IRX-1
, iroquois-class homeodomain protein IRX-3
, Iroquois homeobox protein 3
, homeobox transcription factor iroquois 3
, iroquois type homeobox
, iroquois-class homeodomain protein irx-3
, Iroquois related homeobox 3
, iroquois homeobox protein 3a