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Here, we discuss the roles of lysine 27 demethylases, JMJD3 (show Kdm6b ELISA Kits) and UTX, in cancer and potential therapeutic avenues targeting these enzymes. Despite a high degree of sequence similarity in the catalytic domain between JMJD3 (show Kdm6b ELISA Kits) and UTX, numerous studies revealed surprisingly contrasting roles in cellular reprogramming and cancer, particularly leukemia
we identified a novel de novo deletion of KDM6A in a Chinese girl with KS. We consider her allergic skin manifestations to be part of the phenotypic spectrum of KS
KDM6A and p21CIP1 (show CDKN1A ELISA Kits) expression are essential to curb E7 induced replication stress to levels that do not markedly interfere with cell viability
Study identified a feed-forward loop between UTX and ER in the regulation of hormonally responsive breast carcinogenesis.
Mutation in KDM6A gene is associated with cancer more frequently in males.
Pathogenic variants in KMT2D (show MLL2 ELISA Kits) resulting in protein truncation in 43% (6/14; of which 3 are novel) of all cases were detected, while analysis of KDM6A was negative. MLPA analysis was negative in all instances.
Kdm6a and Kdm6b (show Kdm6b ELISA Kits) were found to be significantly overexpressed in Malignant pleural mesothelioma (MPM) at the mRNA level. However, tests examining if targeting therapeutically Kdm6a/b using a specific small molecule inhibitor was potentially useful for treating MPM, revealed that members of the Kdm6 family may not be suitable candidates for therapy
The results define UTX as a bivalency-resolving histone modifier necessary for stem cell differentiation
UTX gene expression in renal cell carcinoma and bladder cancer.
Mutations of the epigenetic genes KMT2D (show MLL2 ELISA Kits) and KDM6A cause dysregulation of certain developmental genes and account for the multiple congenital anomalies of the syndrome
Long-term exposure to atmospheric particulates, PM2.5 up-regulated H3K4 and H3K9 methylation in IL-6 (show IL6 ELISA Kits) and IFN-beta (show IFNB1 ELISA Kits) promoter regions through down-regulating Kdm6a expression. The results suggest that short-term exposure to PM2.5 significantly enhances the survival rate of influenza A-contaminated mice, while long-term PM2.5 inhalation lowers the capacity of pulmonary macrophages to secrete IL-6 (show IL6 ELISA Kits) and IFN-beta (show IFNB1 ELISA Kits).
UTX-MLL4 (show MLL4 ELISA Kits)-p300 (show NOTCH1 ELISA Kits) transcriptional regulatory network establishing an "active enhancer landscape" and defines a detailed mechanism for the joint deposition of H3K4me1 and H3K27ac.
These results suggest that the demethylase (show MBD2 ELISA Kits) activity of Jmjd3 (show Kdm6b ELISA Kits), but not that of Utx, affects mouse axial patterning in concert with alterations in Hox (show MSH2 ELISA Kits) gene expression.
Utx governs adipogenesis by regulating c-Myc (show MYC ELISA Kits) in a differentiation stage-specific manner
Ectopic expression of KDM6A antagonized TGF-beta (show TGFB1 ELISA Kits)-induced epithelial-mesenchymal transition and cell migration of lung cancer cells through its demethylase (show MBD2 ELISA Kits) activity.
this study reveals how UTX regulates the development of invariant natural killer T cells through multiple epigenetic mechanisms
Study demonstrated that the mammary luminal lineage relies on KDM6A to ensure a transcription program leading to differentiated alveoli. Failure to fully implement this program results in structurally and functionally impaired mammary tissue.
differentiating embryonic stem cells (ESCs (show NR2E3 ELISA Kits)) depend on KDM6 and the H3K27me3 demethylase (show MBD2 ELISA Kits) activity is crucially involved in DNA damage response and survival of differentiating ESCs (show NR2E3 ELISA Kits).
a critical role for the enzymatic activity of UTX in activating muscle-specific (show EIF3K ELISA Kits) gene expression during myofiber regeneration and have revealed a physiological role for active H3K27 demethylation in vivo.
This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3.
lysine (K)-specific demethylase 6A
, bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX))
, histone demethylase UTX
, lysine-specific demethylase 6A
, ubiquitously transcribed tetratricopeptide repeat protein X-linked
, ubiquitously-transcribed TPR gene on the X chromosome
, ubiquitously-transcribed TPR protein on the X chromosome
, ubiquitously transcribed tetratricopeptide repeat, X chromosome
, 4lysine (K)-specific demethylase 6A
, ubiquitously transcribed TPR protein on the X chromosome
, ubiquitously transcribed X chromosome tetratricopeptide repeat protein
, ubiquitously transcribed tetratricopeptide repeat gene, X chromosome
, ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome