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A novel frameshift mutation in PODXL seems to be the likely cause of ARJP in this family.
These findings suggest a potential functional link in colorectal cancer between PODXL, EGFR (show EGFR Proteins) and BRAF (show BRAF Proteins).
PODXL enhances motility and invasiveness through an increase in gelsolin-actin interactions in cell protrusions.
Results identify an anti-metastatic miRNA, miR (show MLXIP Proteins)-5100, that decreases the metastatic ability of pancreatic cancer partially by suppressing expression of PODXL.
Results indicate that urinary podocalyxin is not only an early marker but also a treatment target for diabetic nephropathy (DN).
Obese subjects showed evidence of renal alteration through the detection of a higher number of urinary podocalyxin positive cells.
Data show that both mucin16 (MUC16 (show MUC16 Proteins)) and podocalyxin (PODXL)-E-selectin (show SELE Proteins)-mediated interactions are mechanically stronger than like L-selectin (show SELL Proteins) interactions at the single-molecule level.
In gastric cancer, PODXL expression by the polyclonal antibody HPA2110 is an independent marker of poor prognosis.
PCX (show PC Proteins) promotes cisplatin chemoresistance in osteosarcoma cells through a PI3Kdependent mechanism.
EZR (show EZR Proteins), CLIC5 (show CLIC5 Proteins) and PODXL are overexpressed in hepatocellular carcinoma and may have a role in cell migration and invasiveness
Podxl-KO led to heightened G-CSF (show CSF3 Proteins) activation of Rap1a (show RAP1A Proteins)(GTP (show AK3 Proteins)), and Rap1a (show RAP1A Proteins)(GTP (show AK3 Proteins)) inhibition attenuated Podxl-KO neutrophil migration. Studies have revealed novel roles for Podxl as an important modulator of neutrophil and monocyte formation and of Rap1a (show RAP1A Proteins) activation during stress hematopoiesis.
Podxl-overexpression in neural stem/progenitor cells leads to an up-regulation of Annexin A2 (show ANXA2 Proteins).
when endogenous podocalyxin was removed from highly metastatic 4T1 mammary tumor cells there was a decrease in collective invasion . Podocalyxin is a tumor cell-intrinsic regulator of experimental collective tumor cell invasion and tumor budding.
Podocalyxin has a role in glioblastoma multiforme cell invasion and proliferation via beta-catenin (show CTNNB1 Proteins) signaling
Loss of podocalyxin from the lung vasculature results in changes to the lung structure and function including increased lung volume when inflated under constant pressure (25 cm H2O) and changes to the matrix composition.
CTGF is an important mediator of high glucose-induced podocyte damage and decreases the protein level of podocalyxin by the ERK1/2 pathway.
platelet Podxl is involved in the control of hemostasis acting as a platelet co-stimulator, likely due to its pro-adhesive properties
Full-length recombinant murine podocalyxin recruits NHERF-1 (show SLC9A3R1 Proteins) to the apical domain. Ectopic expression in human & canine epithelial cells leads to microvilli formation on an apical domain extending laterally to the junctional complexes.
Podocalyxin plays multiple roles in neural development
PODXL may act as a costimulator of agonists in the activation of platelets and formation of a stable thrombus.
This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin.
, podocalyxin-like protein 1-like
, GCTM-2 antigen
, podocalyxin-like protein 1
, PC-like protein 1
, Podocalyxin-like protein 1