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Summary of the structural features of podocalyxin glycoforms from embryonic and induced pluripotent stem cells (review).
This set of symptoms strikingly mimics previously reported mouse Podxl(-/-) embryos, emphasizing the essential function of PODXL in mammalian kidney development and highlighting this patient as a human PODXL-null model.
These results indicate that PcMab-47 is useful in detecting podocalyxin of oral cancers for immunohistochemical analysis
expression of PODXL associates with TAZ (show TAZ Proteins) downstream gene expression. Suppression of PODXL induces phosphorylation of LATS1 and TAZ (show TAZ Proteins), and is accompanied with a decrease in TAZ (show TAZ Proteins) protein expression. We speculate that changes in actin cytoskeleton may participate in PODXL-mediated TAZ (show TAZ Proteins) signaling.
Results show that PODXL performs as a tumor promoter in gastric tumor cells (GC). PODXL is a target gene of miR (show MLXIP Proteins)-509-3-5P; the ectopic expression of miR (show MLXIP Proteins)-509-3-5P in GC cell lines inhibits the colony, motility and invasion abilities via negatively targeting PODXL.
Podocalyxin as a major pluripotent marker and novel keratan sulfate proteoglycan (show LUM Proteins) in human embryonic and induced pluripotent stem cells.
A novel frameshift mutation in PODXL seems to be the likely cause of ARJP in this family.
These findings suggest a potential functional link in colorectal cancer between PODXL, EGFR (show EGFR Proteins) and BRAF (show BRAF Proteins).
PODXL enhances motility and invasiveness through an increase in gelsolin-actin interactions in cell protrusions.
Results identify an anti-metastatic miRNA, miR (show MLXIP Proteins)-5100, that decreases the metastatic ability of pancreatic cancer partially by suppressing expression of PODXL.
Podocalyxin-like protein 1 is a relevant marker for human c-kit(pos) cardiac stem cells.(
Podxl-KO led to heightened G-CSF (show CSF3 Proteins) activation of Rap1a (show RAP1A Proteins)(GTP (show AK3 Proteins)), and Rap1a (show RAP1A Proteins)(GTP (show AK3 Proteins)) inhibition attenuated Podxl-KO neutrophil migration. Studies have revealed novel roles for Podxl as an important modulator of neutrophil and monocyte formation and of Rap1a (show RAP1A Proteins) activation during stress hematopoiesis.
Podxl-overexpression in neural stem/progenitor cells leads to an up-regulation of Annexin A2 (show ANXA2 Proteins).
when endogenous podocalyxin was removed from highly metastatic 4T1 mammary tumor cells there was a decrease in collective invasion . Podocalyxin is a tumor cell-intrinsic regulator of experimental collective tumor cell invasion and tumor budding.
Podocalyxin has a role in glioblastoma multiforme cell invasion and proliferation via beta-catenin (show CTNNB1 Proteins) signaling
Loss of podocalyxin from the lung vasculature results in changes to the lung structure and function including increased lung volume when inflated under constant pressure (25 cm H2O) and changes to the matrix composition.
CTGF is an important mediator of high glucose-induced podocyte damage and decreases the protein level of podocalyxin by the ERK1/2 pathway.
platelet Podxl is involved in the control of hemostasis acting as a platelet co-stimulator, likely due to its pro-adhesive properties
Full-length recombinant murine podocalyxin recruits NHERF-1 (show SLC9A3R1 Proteins) to the apical domain. Ectopic expression in human & canine epithelial cells leads to microvilli formation on an apical domain extending laterally to the junctional complexes.
Podocalyxin plays multiple roles in neural development
This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin.
, podocalyxin-like protein 1
, PC-like protein 1
, Podocalyxin-like protein 1
, podocalyxin-like protein 1-like