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anti-Human ZIC2 Antibodies:
anti-Rat (Rattus) ZIC2 Antibodies:
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Guinea Pig Polyclonal ZIC2 Primary Antibody for IHC, WB - ABIN2776475
McCampbell, Truong, Broom, Allchorne, Gable, Cutler, Mattson, Woolf, Frosch, Harmon, Dunn, Brown: Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy. in Human molecular genetics 2005
Show all 4 Pubmed References
Human Polyclonal ZIC2 Primary Antibody for ELISA, WB - ABIN4366903
Sakuma, Kasamatsu, Yamatoji, Yamano, Fushimi, Iyoda, Ogoshi, Shinozuka, Ogawara, Shiiba, Tanzawa, Uzawa: Expression status of Zic family member 2 as a prognostic marker for oral squamous cell carcinoma. in Journal of cancer research and clinical oncology 2010
miR (show MLXIP Antibodies)-1271/Zic2/PAK4 (show PAK4 Antibodies) axis plays an important role in hepatocellular carcinoma progression.
Together SMAD3 (show SMAD3 Antibodies) and ZIC2 regulate FOXA2 (show FOXA2 Antibodies) transcription in cultured cells and Zic2 also controls the foxA2 (show FOXA2 Antibodies) expression during Xenopus development. These findings reveal a new mechanism of NODAL signal transduction in the mammalian node and provide the first molecular explanation of how ZIC2 loss-of-function precipitates Holoprosencephaly (HPE
Data show that Zinc finger protein ZIC 2 (ZIC2) is indispensable in the regulation of pancreatic ductal adenocarcinoma (PDAC) cell apoptosis.
ZIC2 acts upstream of OCT4 (show POU5F1 Antibodies) and recruits the nuclear remodeling factor complex to the OCT4 (show POU5F1 Antibodies) promoter, initiating OCT4 (show POU5F1 Antibodies) activation. ZIC2 levels positively correlated to the clinicopathological stages of HCC (show FAM126A Antibodies) patients.
Mutational screening for HPE genes revealed the occurrence of a frameshift mutation in the ZIC2 gene.
ZIC2 and RASGRF1 (show RASGRF1 Antibodies) are susceptibility genes, not only for common myopia, but also for high myopia.
The c.1401_1406dup (p.Ala469_470dup) or alanine tract expansion to 17 residues) in the ZIC2 gene are likely to be medically significant for holoprosencephaly in a Brazilian cohort.
A high level of sequence variation in the 3'UTR (show UTS2R Antibodies) of ZIC2 may be associated with holoprosencephaly.
ZIC2, a transcription factor related to the sonic hedgehog (show SHH Antibodies) pathway, is a strong discriminant between MAL and LMP (show PDLIM7 Antibodies) tumors: it may be a major determinant of outcome of EOTs.
Mutations in ZIC2 is associated with holoprosencephaly.
these data establish zic2 mutant zebrafish as a powerful new genetic model for in-depth dissection of cell interactions and genetic controls during craniofacial complex development.
Zic2a and Zic2b play a dual role during craniofacial development, in neural crest induction and migration, and in craniofacial chondrogenesis patterning
Zic2a and Zic5 (show ZIC5 Antibodies) have essential, cooperative roles in promoting cell proliferation in the tectum, but lack obvious patterning functions.
the results identify Zic2a as a novel regulator of prethalamic development, and show that it functions independently of hedgehog (show SHH Antibodies) signaling.
Zic2a and zic5 (show ZIC5 Antibodies) as crucial players in the genetic network linking patterned gene expression to morphogenetic changes during neurulation.
These data uncover a novel, essential role for Zic2a as a modulator of Hedgehog (show SHH Antibodies)-activated gene expression in the developing forebrain
Zic2 and Zic1 (show ZIC1 Antibodies) proteins are essential to control the balance between two defined neuron types in the postnatal forebrain.
This shift in the major acting transcription factors appears to be primed by binding of ZIC2 in embryonic stem cells at relevant genomic positions.
Here, we reveal a previously unknown role for Zic2 in the migration of forebrain neurons such as Cajal-Retzius cells, interneurons moving to the ventral lateral geniculate nucleus, and neocortical cells going to the amygdala.
Zic1 (show ZIC1 Antibodies) and Zic2 are required for coordinating mature neuronal gene expression patterns.
Zic2 loss-of-function doesn't prevent initial otocyst patterning but leads to molecular abnormalities concomitant with morphogenesis of the endolymphatic duct.
Zic2 is a key factor in the execution of transcriptional fine-tuning with Mbd3 (show MBD3 Antibodies)/NuRD in embryonic stem cells through interactions with enhancers.
Zic2 appears to be a component of the gene regulatory network that drives ciliation of node cells during gastrulation.
results reveal a Zic2-dependent mechanism, shared by different neural populations, essential to prevent midline crossing during the development of the nervous system.
Explant culture of Zic2(m1Nisw) gastrointestinal tract show extensive neurite outgrowth, suggesting that Zic2 is a negative regulator of nerve fiber growth.
Among three novel missense mutations in ZIC2, R409P was only found in schizophrenia patients, and was located in a strongly conserved position of the zinc finger domain.
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.
Zic family member 2 (odd-paired homolog, Drosophila)
, Zinc finger protein of the cerebellum 2
, zinc finger protein ZIC 2
, cerebellum zinc finger protein 2
, zinc finger protein of the cerebellum 2
, zinc finger cerebellum 2
, GENA 29
, odd-paired homolog