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General |
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Antigen | Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A) Antibodies |
Epitope | pThr286 Alternatives |
Reactivity | Human, Mouse (Murine), Rat (Rattus), Xenopus laevis Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | This CAMK2A antibody is un-conjugated Alternatives |
Application |
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Alternatives
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Product Details anti-CAMK2A AntibodyTarget Details CAMK2A Application Details Handling Images |
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Specificity | This antibody recognizes Calcium/Calmodulin-dependent Protein Kinase Type II (CAMK2). Specific for the ~50k a-CaM Kinase II and the ~60k R-CaM Kinase II proteins phosphorylated at Thr286. Immunolabeling is blocked by the X-phosphatase treatment. |
Cross-Reactivity (Details) |
Species reactivity (expected):Human, Mouse, Xenopus. Species reactivity (tested):Rat. |
Purification | Immunoaffinity Chromatography |
Immunogen | Phosphopeptide corresponding to amino acid residues surrounding the phosphoThr286 found in Rat brain CaM Kinase II. |
Isotype | IgG |
Plasmids, Primers & others | |
Target Details CAMK2AProduct Details anti-CAMK2A Antibody Application Details Handling Images back to top |
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Antigen | |
Alternative Name | CAMK2A (CAMK2A Antibody Abstract) |
Background | CaMKII (Calcium/calmodulin-dependent protein kinase II) is a ubiquitous serine/threonine protein kinase that is abundant in the brain as a major constituent of the postsynaptic density (PSD). The enzyme is an oligomeric protein composed of distinct but related subunits, alpha, beta, gamma, and delta, each encoded by a separate gene. CAMK2A assembles into heterooligomeric complexes with other CAMK2 subunits. CaMKII is a prominent kinase in the central nervous system that may function in long term potentiation and neurotransmitter release.Synonyms: CAMK2A, CAMK2B, CAMKA, CaM kinase II subunit alpha, CaM kinase II subunit beta, CaM-kinase II alpha chain, CaM-kinase II beta chain, CaMK-II subunit alpha, CaMK-II subunit beta, Calcium/Calmodulin-dependent Protein Kinase Type II, KIAA0968 |
Gene ID | 815 |
NCBI Accession | NP_741960 |
UniProt | Q9UQM7 |
Pathways | WNT Signaling, Interferon-gamma Pathway, Myometrial Relaxation and Contraction |
Application DetailsProduct Details anti-CAMK2A Antibody Target Details CAMK2A Handling Images back to top |
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Application Notes |
Immunohistochemistry on paraffin sections: 1/200. Western blot: 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. |
Restrictions | For Research Use only |
HandlingProduct Details anti-CAMK2A Antibody Target Details CAMK2A Application Details Images back to top |
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Format | Liquid |
Buffer | 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol |
Handling Advice | Avoid repeated freezing and thawing. |
Storage | 4 °C/-20 °C |
Storage Comment | Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. |
ImagesProduct Details anti-CAMK2A Antibody Target Details CAMK2A Application Details Handling back to top |
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Supplier Images |