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Results show that missense mutations exert dominant negative effects on the keratins K1/K10 (show KRT10 Proteins) protein structure by altering inter-chain interactions.
casein kinase 1 phosphorylates the SQSTM1 (show SQSTM1 Proteins) S349 residue when harmful proteins accumulate under HSF1 (show HSF1 Proteins) stress
Maintenance of the progenitors thus requires cooperation by PRMT1 (show PRMT1 Proteins) and CSNK1a1 to sustain proliferation gene expression and suppress premature differentiation driven by GRHL3 (show GRHL3 Proteins)
These data indicate that CK1alpha has a dominant and non-redundant function in melanoma cells
KRT1 and the specific polymorphism of KRT1 in this Chinese Han population are associated with autoimmune diseases SLE and SSc (show CYP11A1 Proteins)
Disruption of CK1alpha function in myeloma cells resulted in decreased Mdm2 (show MDM2 Proteins), increased p53 (show TP53 Proteins) and p21 (show CDKN1A Proteins) and reduced expression of beta-catenin (show CTNNB1 Proteins) and AKT (show AKT1 Proteins).
CK1delta enhances EPO (show EPO Proteins) secretion from liver cancer cells under hypoxia by modifying HIF-2alpha (show EPAS1 Proteins) and promoting its nuclear accumulation.
CKIalpha-mediated NS5A S235 phosphorylation is critical for HCV replication. CaMKII (show CAMK2G Proteins) gamma and delta may have negative roles in the HCV life cycle.
Case Report: post-zygotic mosaicism of KRT/1o mutations in epidermolytic Ichthyosis (show LBR Proteins).
KRT1 played an important role of maintaining epithelial barrier and its down-regulation in intestinal tissue was correlated with the progression of inflammatory bowel disease.
Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1alpha has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis.
Phosphorylation of LRRK2 by casein kinase 1alpha regulates trans-Golgi clustering via differential interaction with ARHGEF7 (show ARHGEF7 Proteins).
Phosphorylation of FADD (show FADD Proteins) by the kinase CK1alpha promotes KRASG12D-induced lung cancer.
Csnk1a1 knockdown results in decreased Rps6 (show RPS6 Proteins) phosphorylation, increased p53 (show TP53 Proteins) activity, and myeloid differentiation.
study for the first time demonstrates that CK1alpha is required for chromosome alignment and segregation during oocyte meiotic maturation and early embryo development
Silencing or deleting the p53 (show TP53 Proteins) gene demonstrated that genotoxic stress elicited Wnt (show WNT2 Proteins) signaling in a p53 (show TP53 Proteins)-independent manner. Instead, this response occurred through reduced abundance of Csnk1a1 (CK1alpha), a kinase that inhibits beta-catenin (show CTNNB1 Proteins).
maintenance of intestinal homeostasis in CKIalpha-deficient gut (show GUSB Proteins) requires p53 (show TP53 Proteins)-mediated growth control, because the combined ablation of Csnk1a1 and either p53 (show TP53 Proteins) or its target gene p21 triggered high-grade dysplasia with extensive proliferation
Casein kinase I (show CSNK1D Proteins) and casein kinase II (show CSNK2A1 Proteins) differentially regulate axin (show AXIN1 Proteins) function
CK1alpha-mediated phosphorylation modulates the mRNA binding ability of hnRNP-C
CK1 regulates fast synaptic transmission by glutamate (show GRIN1 Proteins) in brain. Activation of CK1 decreases NMDA receptor activity in the striatum via activation by this kinase of protein phosphatase 1 (show PPP1CB Proteins) &/or 2A & increased dephosphorylation of NMDA receptors.
Here, we report that in response to factors that promote cell motility, the Rap guanine exchange factor RAPGEF2 is rapidly phosphorylated by I-kappa-B-kinase-beta and casein kinase-1alpha and consequently degraded by the proteasome.
The phosphorylation of p53 (show TP53 Proteins) by CK1 is an isoform-specific reaction to the K(221)RQK(224) loop.
data provide a molecular insight into the structural features that underlie the site specificity of CK1a
we identify Casein Kinase I alpha (CK1alpha) as an additional negative-regulator of Cap-H2. CK1a-depletion stabilizes Cap-H2 protein and results in an accumulation of Cap-H2 on chromosomes.
Expected genes in the Scar-Arp2 (show ACTR2 Proteins)/3 actin (show ACTB Proteins) nucleation pathway were identified as well as casein kinase I, which had a similar morphological RNAi signature.
CKI(Casein kinase I) functions as a negative regulator of Arm protein, by phosphorylating it on Ser (show SIGLEC1 Proteins) and Thr (show TRH Proteins) residues in the N-terminus and targeting it for degradation.
2 proteins reported to function in Wingless(Wg) signaling identified as Hh pathway components: Dally-like protein required for Hh signal reception, and casein kinase 1alpha, a candidate tumor suppressor that regulates activities of both Hh and Wg pathways
expression of doubletime in Drosophila S2 cells produced a CKI-7-sensitive kinase activity which was reduced by both the dbt(S) and dbt(L) mutations of circadian rhythm
doubletime and CKII (show CSNK2A1 Proteins) kinases collaborate to potentiate Drosophila PER transcriptional repressor activity
Several CKI isoforms including CKIalpha and Gish/CKIgamma can phosphorylate the Wg coreceptor Arrow (Arr), which may account, at least in part, for their positive roles in the Wg pathway.
Mutation of ck1alpha or -epsilon or sgg/gsk3beta in wing imaginal discs results in the accumulation of dMyc protein, suggesting a physiological role for these kinases in vivo.
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
, casein kinase I isoform alpha
, clock regulator kinase
, down-regulated in lung cancer
, 67 kDa cytokeratin
, cytokeratin 1
, epidermolytic hyperkeratosis 1
, hair alpha protein
, keratin, type II cytoskeletal 1
, type-II keratin Kb1
, casein kinase I-alpha
, casein kinase I alpha LS
, protein kinase CK1 (casein kinase 1) isoform alpha
, casein kinase 1 alpha
, caesin kinase I alpha
, casein kinase 1
, casein kinase 1a
, casein kinase 1alpha
, casein kinase I
, casein kinase ialpha