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anti-Mouse (Murine) CTNNB1 Antibodies:
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Human Polyclonal CTNNB1 Primary Antibody for CyTOF, FACS - ABIN4899451
Sáenz-Morales, Escribese, Stamatakis, García-Martos, Alegre, Conde, Pérez-Sala, Mampaso, García-Bermejo: Requirements for proximal tubule epithelial cell detachment in response to ischemia: role of oxidative stress. in Experimental cell research 2006
Show all 13 Pubmed References
Human Monoclonal CTNNB1 Primary Antibody for WB - ABIN1882227
Huang, Wang, Guo, Jia, Lin, Li, Wang, Chen: Approaching the intrinsic electron field-emission of a graphene film consisting of quasi-freestanding graphene strips. in Small (Weinheim an der Bergstrasse, Germany) 2011
Show all 5 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for WB - ABIN1881236
Huang, Zhou, Saberwal, Konieczna, Horvath, Katsoulidis, Platanias, Eklund: Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription. in Molecular and cellular biology 2010
Show all 5 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for WB - ABIN1881237
Chairoungdua, Smith, Pochard, Hull, Caplan: Exosome release of ?-catenin: a novel mechanism that antagonizes Wnt signaling. in The Journal of cell biology 2010
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Human Polyclonal CTNNB1 Primary Antibody for FACS, IF - ABIN1881238
Mirza, Sun, Zhao, Potula, Frey, Vogel, Malik, Zhao: FoxM1 regulates re-annealing of endothelial adherens junctions through transcriptional control of beta-catenin expression. in The Journal of experimental medicine 2010
Show all 5 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for FACS, IF - ABIN1881239
Teng, Wang, Wang, Wang: [Effect of siRNA-mediated beta-catenin gene on Wnt signal pathway in lung adenocarcinoma A549 cell]. in Zhonghua yi xue za zhi 2010
Show all 5 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for EIA, IF - ABIN951058
Guo, Shen, Liao, Lian, Wang: NGX6 inhibits cell invasion and adhesion through suppression of Wnt/beta-catenin signal pathway in colon cancer. in Acta biochimica et biophysica Sinica 2010
Show all 4 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for ICC, IHC (fro) - ABIN5518651
Zhao, Li, Gao, Wang, Yan, Zhan, Liu, Mao, Chen, Wang et al.: Design, synthesis and biological evaluation of N-alkyl or aryl substituted isoindigo derivatives as potential dual cyclin-dependent kinase 2 (CDK2)/glycogen synthase kinase 3? (GSK-3?) ... in European journal of medicinal chemistry 2014
Show all 3 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for ICC, IHC (fro) - ABIN3044344
Hao, Wen, Li, Wang, Ni, Wang, Wang, Sun, Fan, Mao: LiCl inhibits PRRSV infection by enhancing Wnt/?-catenin pathway and suppressing inflammatory responses. in Antiviral research 2015
Show all 3 Pubmed References
Human Monoclonal CTNNB1 Primary Antibody for ICC, FACS - ABIN969072
Bougatef, Ouerhani, Moussa, Kourda, Coulet, Colas, Lahely, Najjar, Ben Jilani, Benammar-Elgaaied, Soubrier, Marrakchi: Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer. in Cancer genetics and cytogenetics 2008
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temporal expression of CTNNB1 mRNA during dermal wound repair in the horse
Data show that phospholipase C (PLC (show PLC Antibodies))-beta1 (PLC (show HSPG2 Antibodies)-beta1) overexpression determines an increase in beta-catenin translocation and that PLC (show HSPG2 Antibodies)-beta1, inositol polyphosphate multikinase (IPMK (show IPMK Antibodies)) and beta-catenin are mediators of the same signaling pathway.
FGF23 (show FGF23 Antibodies) promotes myocardial fibrosis and exacerbates diastolic dysfunction induced by myocardial infarction or ischemia/reperfusion , which is associated with the upregulation of active beta-catenin and TGF-beta (show TGFB1 Antibodies)
Suggest that Pygo2 has a tumor promoting function related to Wnt/ss-catenin signaling activity during intestinal tumor initiation and progression.
Data suggest that Wnt (show WNT2 Antibodies) signaling directs fatty acid metabolism via canonical mechanism involving activation of beta-catenin in osteoblasts; beta-catenin accumulation and activation are required for normal lipid catabolism in osteoblasts and white adipose tissue.
Stretch induced p120 (show CTNND1 Antibodies) degradation and the endocytosis of E-cadherin (show CDH1 Antibodies), which induced beta-catenin translocation into the nucleus, a key event in lung injury progress and repair.
Expression of a dominant stable form of beta-catenin in hepatocytes results in severe cholestasis and biliary type fibrosis.
These data suggested that Wnt (show WNT2 Antibodies)/beta-catenin pathway might be a potential target to treat the LPS (show TLR4 Antibodies)-induced inflammation in ALI.
Data show that Wnt (show WNT2 Antibodies) beta-Catenin signaling pathway activation followed by Notch (show NOTCH1 Antibodies) inhibition strongly promotes the mitotic regeneration of new hair cell (HC) in both normal and neomycin-damaged cochleae.
KY1022, a small molecule that destabilizes both beta-catenin and Ras by targeting the Wnt (show WNT2 Antibodies)/beta-catenin pathway, inhibitits cellular events, including epithelial mesenchymal transformation, an initial process of metastasis, and apoptosis in colorectal cancer cells.
Cardiomyocyte hypertrophy is blunted with cardiac fibroblast-specific loss of beta-catenin after trans-aortic constriction in vivo.
Net1-regulated beta-catenin activation plays a crucial role in the dorsal axis formation during zebrafish development.
Wnt (show WNT2 Antibodies)/beta-catenin signaling induces expression of col12a1a/b and deposition of Collagen XII, which is necessary for axons to actively navigate the non-neural lesion site environment.
Mechanistically, Hif-3alpha2 binds to beta-catenin and destabilizes the nuclear beta-catenin complex.
Nuclear beta-catenin is an indication of an activated Wnt (show WNT2 Antibodies) pathway, therefore suggesting a possible role for Wnt (show WNT2 Antibodies) signalling during zebrafish tooth development and replacement.
Findings suggest that microRNA 19b (miR (show MYLIP Antibodies)-19b) regulates laterality development and heart looping in embryos by targeting beta-catenin ctnnb1.
Custos binds to beta-catenin in a Wnt (show WNT2 Antibodies) responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.
The role of the beta-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila.
The Wnt (show WNT2 Antibodies)/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality. (Review)
This study demonstrated that beta-catenin/Wnt (show WNT2 Antibodies) signaling is initially required to activate cell-cycle re-entry in Muller glia following injury and that Wnt (show WNT2 Antibodies) signaling subsequently controls the fate of the progeny of those cell divisions.
A novel role for Eaf1 (show EAF1 Antibodies) and Eaf2 (show EAF2 Antibodies) in inhibiting canonical Wnt (show WNT2 Antibodies)/beta-catenin signaling, which might form the mechanistic basis for Eaf1 (show EAF1 Antibodies) and Eaf2 (show EAF2 Antibodies) tumor suppressor activity.
We identified the amphibian leap2 (show LEAP2 Antibodies) gene which is highly related to its mammalian orthologues at both structural and sequence levels. The gene is expressed in the embryo mostly in the endoderm-derived tissues. Accordingly it is induced in pluripotent animal cap cells by FGF, activin (show Actbeta Antibodies) or a combination of vegT/beta-catenin.
Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A (show PPP2R2B Antibodies) and thereby down-regulating the Wnt (show WNT2 Antibodies)/beta-catenin signaling.
maternal Wnt (show WNT2 Antibodies)/STOP signaling, but not beta-catenin signaling, has a role in cleavage after fertilization and cell cycle progression
Wnt (show WNT2 Antibodies) signalling can benefit from nucleo-cytoplasmic shuttling of APC (show APC Antibodies), Axin (show AXIN1 Antibodies) and GSK3, although they are in general beta-catenin antagonising proteins.
Phosphoinositide 3-kinase and Rac (show AKT1 Antibodies) polarization depend specifically on the N-cadherin (show CDH2 Antibodies)-p120 catenin (show CTNND1 Antibodies) complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin (show CDH2 Antibodies)-beta-catenin complex.
HERG (show KCNH2 Antibodies) channel activity is stimulated by beta-catenin
Zic3 (show ZIC3 Antibodies) can suppress Wnt (show WNT2 Antibodies)/beta-catenin signaling and control development of the notochord and Spemann's organizer.
Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3
The tyrosine kinase receptor (show KDR Antibodies), PTK7 (show PTK7 Antibodies), is implicated in beta-catenin-dependent developmental processes.
This beta-catenin-mediated activation of PHB (show PHB Antibodies) expression was independent of cMYC (show MYC Antibodies) activation, a product of Wnt (show WNT2 Antibodies) signaling.These data indicate that PHB (show PHB Antibodies) is a direct target of beta-catenin and the increased level of PHB (show PHB Antibodies) in leukemia can be regulated by Wnt (show WNT2 Antibodies) signaling
Silencing p65 (show GORASP1 Antibodies) attenuates FOXM1 (show FOXM1 Antibodies) and beta-catenin expression. NF-kappaB (show NFKB1 Antibodies) activation is required for nuclear translocation of FOXM1 (show FOXM1 Antibodies) and beta-catenin. FOXM1 (show FOXM1 Antibodies) and beta-catenin positively regulate NF-kappaB.Knockdown of beta-catenin and FOXM1 (show FOXM1 Antibodies) downregulates p65 (show GORASP1 Antibodies) protein and NF-kappaB (show NFKB1 Antibodies)-dependent reporter activity.
this study showed that Annexin A2 (show ANXA2 Antibodies) inhibition suppresses proliferation and invasion in ovarian cancer via beta-catenin/EMT (show ITK Antibodies), proposing the potential role of Annexin A2 (show ANXA2 Antibodies) in the prevention and treatment of ovarian cancer
Kindlin-2 (show FERMT2 Antibodies) is up-regulated in glioma cells and acts as an oncogene (show RAB1A Antibodies). It is an independent risk factor for poor prognosis. The Kindlin-2 (show FERMT2 Antibodies)/YB-1 (show YBX1 Antibodies)/beta-catenin complex promotes EGFR (show EGFR Antibodies) transcription and contributes to glioma progression. Kindlin-2 (show FERMT2 Antibodies) is a potential diagnostic and prognostic marker in glioma, and inhibition of Kindlin-2 (show FERMT2 Antibodies) may be a novel strategy for glioma treatment.
USP9X (show USP9X Antibodies) stabilizes beta-catenin and activates Wnt (show WNT2 Antibodies)/beta-catenin signal pathway to promote glioma cell proliferation and survival.
WM130 preferentially inhibits hepatic cancer stem-like cells by suppressing AKT (show AKT1 Antibodies)/GSK3beta/beta-catenin signaling pathway.
SOX7 (show SOX7 Antibodies) inhibits oncogenic beta-catenin-mediated transcription by disrupting the beta-catenin/BCL9 (show BCL9 Antibodies) interaction.
These findings provide mechanistic insight into the WNT-mediated regulation of the DNA damage response and suggest a novel role for the alpha-catenin-beta-catenin complex in the nucleus.
E-cadherin (show CDH1 Antibodies) inhibits beta-catenin in the context of disruption of the APC (show APC Antibodies)-destruction complex, and that this function is also EC1 domain dependent. Both binding functions of E-cadherin (show CDH1 Antibodies) may be required for its tumour suppressor activity.
FOXN3 (show FOXN3 Antibodies) bind to beta-catenin and inhibited beta-catenin/TCF (show HNF4A Antibodies) signaling by blocking the interaction between beta-catenin and TCF4 (show TCF4 Antibodies). Loss of FOXN3 (show FOXN3 Antibodies) in colon cancer activates beta-catenin/TCF (show HNF4A Antibodies) signaling and promotes the growth and migration of cancer cells.
Results highlight a potential role for the beta-catenin/Wnt (show WNT2 Antibodies) and Notch (show NOTCH1 Antibodies) signalling pathways during the infection of crypt cells by L. intracellularis.
Flutamide exposure led to decreased beta-catenin in corpus luteum of mid/late pregnancy.
beta-catenin signaling is involved in formation of contractile membranes by dedifferentiated retinal pigment epithelium cells.
Wnt3a (show WNT3A Antibodies) produced a significant increase in heart valve interstitial cell number at day 4 and in the percentage of BrdU-positive nuclei at 24 h. The increase in proliferation was abolished by beta-catenin siRNA.
beta-catenin controls myocardin (show MYOCD Antibodies)-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes
beta-Catenin plays a critical role in mediating TGF-beta1 (show TGFB1 Antibodies)-induced myofibroblast differentiation in aortic valve interstitial cells.
scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of Glycogen synthase kinase 3beta activity which can lead to activation of the downstream signaling through beta-catenin
Data show that Wnt3a (show WNT3A Antibodies) can inhibit the adipogenic differentiation of porcine AMSCs, and suggest that Wnt (show WNT2 Antibodies)/beta-catenin signaling inhibits adipogenic differentiation potential and alters the cell fate from adipocytes to osteoblasts.
TNF-alpha (show TNF Antibodies) inhibits adipogenesis through stabilization of beta-catenin protein in porcine preadipocytes.
Bovine herpesvirus 1 transiently increased beta-catenin protein levels in bovine kidney cells, but not in rabbit skin cells.
These results demonstrate that activation of AKT (show AKT1 Antibodies) is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.
beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves.
These data demonstrate for the first time that FSH (show BRD2 Antibodies) regulates CTNNB1 protein and WNT2 (show WNT2 Antibodies) mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT (show WNT2 Antibodies) signaling in ovarian steroidogenesis and follicular growth of cattle.
These data provide evidence that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin-targeted genes and myogenesis in the muscle-derived stem cells of cattle.
that beta-catenin is a plasma membrane-associated protein (show PDZK1IP1 Antibodies) in airway smooth muscle that regulates active tension development, presumably by stabilizing cell-cell contacts and thereby supporting force transmission between neighboring cells.
This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin.
TGF-beta3 (show TGFB3 Antibodies) induces the chondrogenic differentiation of pericytes by inducing Wnt (show WNT2 Antibodies)/beta-catenin signaling and T-cell factor-induced gene transcription.
cAMP/PKA regulation of GSK3beta/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.
Palmatin effect on osteoarthritis is likely mediated via the Wnt (show WNT2 Antibodies)/beta-catenin and Hedgehog (show SHH Antibodies) signaling
These results collectively showed that 2-Deoxy-D-glucose regulates dedifferentiation via beta-catenin pathway in rabbit articular chondrocytes.
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
catenin beta 1 subunit
, catenin beta-1
, beta catenin 1
, catenin (cadherin-associated protein), beta 1, 88kDa
, catenin beta-1-like
, catenin (cadherin associated protein), beta 1, 88kDa
, catenin beta
, beta catenin