Browse our anti-CTNNB1 (CTNNB1) Antibodies

Horse (Equine) Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. significantly increased gene expression in early osteochondrosis osteochondral junction chondrocytes compared to controls

2. temporal expression of CTNNB1 mRNA during dermal wound repair in the horse

Mouse (Murine) Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. This study suggests that glutamine could protect against oxidative stress-induced injury in Alzheimer's disease (AD) mice via the Wnt3a/beta-catenin signaling pathway.

2. Study shows that IKKbeta promotes adipogenesis but inhibits osteogenesis in murine and human mesenchymal stem cells (MSCs) through an NF-kappaB-independent mechanism. IKKbeta is a beta-catenin kinase that phosphorylates the degron motif of beta-catenin to prime it for beta-TrCP-mediated ubiquitination and degradation, thereby regulating MSC fate.

3. These data suggest that intervertebral disc degeneration is associated with loss of Wnt signaling and that the concomitant increase in b-catenin is a regenerative response, potentially offering a therapeutic approach to degeneration.

4. The authors demonstrated that FGF7 could increase the expression of Cx43 in osteocytes and promote the cell processes in the form of gap junctions between osteocytes. This modulation was due to the FGF7-induced cytoplasmic accumulation and resultant nuclear translocation of beta-catenin.

5. Skeletal muscle stem cells underwent a switch from beta-catenin-Lef1 to Smad3-Lef1 interactions during the postnatal switch from proliferation to quiescence, with beta-catenin-Lef1 interactions recurring during damage-induced reactivation.

6. Hepatocellular carcinomas with mutations that activate beta-catenin are characterized by increased uptake of a fluorocholine tracer, and can be detected by PET scan.

7. IKKbeta negatively regulates vascular smooth muscle cell calcification through beta-catenin-Runx2 signaling.

8. Conditional loss of Apc resulted in the expression of nuclear beta-catenin throughout the developing mouse liver and increased number of cells expressing glutamine synthetase.

9. After ischemia-reperfusion injury in conditional knockout mice in which beta-catenin was specifically ablated in fibroblasts (Gli1-beta-cat-/-),there was less apoptosis, cytochrome C release, serum creatinine, and damage. Gene expression and phosphorylation of many proteins were affected, including HGF. Fibroblast-specific beta-catenin signaling can control tubular injury and repair in AKI by modulating HGF expression.

10. Despite the induction of oxidative and metabolic stresses, Shp2 deletion in hepatocytes suppressed hepatocarcinogenesis driven by overexpression of oncoproteins MET/CAT or MET/PIK. Shp2 loss inhibited proliferative signaling from c-Met, Wnt/beta-catenin, Ras/Erk and PI3K/Akt pathways, but triggered cell senescence following exogenous expression of the oncogenes.

11. Let-7c inhibits cholangiocarcinoma growth but promotes tumor cell invasion and growth at extrahepatic sites at least in part, through regulation of EZH2 protein expression and through the DVL3/beta-catenin axis.

12. Stromal beta-catenin is essential for kidney development by regulating medulla formation through the differentiation of medullary stromal cells.

13. when CTLA-4 and PD-1 antibodies were combined with DCR-BCAT in MMTV-Wnt1 transgenic mice, a genetic model of spontaneous Wnt-driven tumors, complete regressions were achieved in the majority of treated subjects. These data support RNAi-mediated b-catenin inhibition as an effective strategy to increase response rates to cancer immunotherapy.

14. Data indicate a function of GATA binding protein 4 (GATA4) as a cardiac repressor of the transcription factor 7-like 2 protein (TCF7L2)/beta-catenin complex.

15. Bioinformatic analysis of the protein networks implies potentially novel functions for beta-catenin, particularly in mRNA translation, and we confirm a direct interaction between beta-catenin and the fragile X mental retardation protein (FMRP).

16. Ablation of beta-catenin resulted in STAT3 downregulation and STAT1 activation, leading to elevated macrophage inflammatory responses and increased atherosclerosis in Ldl receptor deficient mice.

17. This study show that beta-catenin in excitatory neurons of the adult neocortex is essential for the optimal processing of visual information.

18. nuclear organization of motor neurons is dependent on inside-out positioning, orchestrated by N-cadherin, catenin, and afadin activities, controlling cell body layering on the medio-lateral axis.

19. these indicate that SLIT3/ROBO2 promotes chondrocyte maturation via the inhibition of beta-catenin signaling.

20. mechanical unloading decreases MACF1 expression, and MACF1 up-regulates osteoblast proliferation through enhancing beta-catenin signaling. This study has thus provided a mechanism for mechanical unloading-induced inhibited osteoblast proliferation.

Zebrafish Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. Studied apoptosis and the Wnt/beta-catenin pathway in the cases of bisphenol A (BPA) and di(2-ethylhexyl) phthalate (DEHP) exposure in zebrafish embryos.

2. Wnt/beta-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling in the process of neovascularization of the central nervous system and blood-brain barrier formation.

3. The results demonstrate that the argon plasma jet has no adverse effects on fin regeneration and embryogenesis in zebrafish, and does not interrupt the (Wnt)/beta-Catenin-signaling pathways.

4. The expression of c-kit and beta-catenin suggests that erythropoietin may exert a role in regeneration reducing the extent of tubular damage from the outset after gentamicin administration.

5. Net1-regulated beta-catenin activation plays a crucial role in the dorsal axis formation during zebrafish development.

6. Wnt/beta-catenin signaling induces expression of col12a1a/b and deposition of Collagen XII, which is necessary for axons to actively navigate the non-neural lesion site environment.

7. Mechanistically, Hif-3alpha2 binds to beta-catenin and destabilizes the nuclear beta-catenin complex.

8. Nuclear beta-catenin is an indication of an activated Wnt pathway, therefore suggesting a possible role for Wnt signalling during zebrafish tooth development and replacement.

9. Findings suggest that microRNA 19b (miR-19b) regulates laterality development and heart looping in embryos by targeting beta-catenin ctnnb1.

10. Custos binds to beta-catenin in a Wnt responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.

11. The role of the beta-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila.

12. The Wnt/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality. (Review)

13. This study demonstrated that beta-catenin/Wnt signaling is initially required to activate cell-cycle re-entry in Muller glia following injury and that Wnt signaling subsequently controls the fate of the progeny of those cell divisions.

14. A novel role for Eaf1 and Eaf2 in inhibiting canonical Wnt/beta-catenin signaling, which might form the mechanistic basis for Eaf1 and Eaf2 tumor suppressor activity.

15. Ccr7 functions during axis formation as a GPCR to inhibit beta-catenin, likely by promoting Ca(2+) transients throughout the blastula.

16. ctnnb1 and ctnnb2 regulate multiple processes of laterality development in zebrafish embryos through similar and distinct mechanisms.

17. 2-OST functions within the Wnt pathway, downstream of Wnt ligand signaling and upstream of Gsk3beta and beta-catenin intracellular localization and function

18. It was shown that Wnt3a-Wnt8a/beta-catenin signaling directly regulates ciliogenic transcription factor foxj1a expression and ciliogenesis in zebrafish Kupffer's vesicle.

19. A Disc1 peptide binds to GSK3beta, and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin-mediated Wnt signaling and inhibiting GSK3beta activity.

20. Foxo3b played a very important role in embryogenesis and negatively regulated maternal and zygotic Wnt/beta-catenin signaling by directly interacting with both beta-catenin1 and beta-catenin2.

Xenopus laevis Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. We identified the amphibian leap2 gene which is highly related to its mammalian orthologues at both structural and sequence levels. The gene is expressed in the embryo mostly in the endoderm-derived tissues. Accordingly it is induced in pluripotent animal cap cells by FGF, activin or a combination of vegT/beta-catenin.

2. Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A and thereby down-regulating the Wnt/beta-catenin signaling.

3. maternal Wnt/STOP signaling, but not beta-catenin signaling, has a role in cleavage after fertilization and cell cycle progression

4. Custos binds to beta-catenin in a Wnt responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.

5. Wnt signalling can benefit from nucleo-cytoplasmic shuttling of APC, Axin and GSK3, although they are in general beta-catenin antagonising proteins.

6. Phosphoinositide 3-kinase and Rac polarization depend specifically on the N-cadherin-p120 catenin complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin-beta-catenin complex.

7. HERG channel activity is stimulated by beta-catenin

8. Zic3 can suppress Wnt/beta-catenin signaling and control development of the notochord and Spemann's organizer.

9. Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3

10. The tyrosine kinase receptor, PTK7, is implicated in beta-catenin-dependent developmental processes.

11. Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity.

12. Activated Xenopus CTNNB1 regulates embryonic limb development via FGF signaling

13. data demonstrate a positive role for protein phosphatase 2A:B56epsilon in the Wnt/beta-catenin signaling pathway

14. Data support a mechanism in which maternal XSOX3 inhibits beta-catenin-mediated axis specification by repressing expression of Xnr5.

15. Chordin, Noggin, beta-Catenin, and Cerberus have roles in neural induction in Xenopus

16. Sox17 and beta-catenin interact to transcribe endodermal target genes

17. The localized activation of Wnt/beta-catenin signaling, which converts Tcf from a repressor to an activator, is required for the establishment of dorsal-ventral patterning in the prospective diencephalon.

18. Expression of Btg-x protein is regulated by both beta-Catenin and Nodal-related signals.

19. High activity of beta catenin led to efficient cell sorting from the notochord to the somites, whereas reduced activity led to sorting in the opposite direction.

20. Tcf/Lef genes encode factors of different activities, which function together in antagonistic or synergistic ways to modulate the intensity and outcome of Wnt/beta-catenin signalling and to trigger tissue-specific responses.

Human Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. The expression of beta-catenin was found to be significantly associated with shorter survival of osteosarcoma patients and disease progression. beta-catenin's expression might be used as a prognostic marker for osteosarcomas. Additional results showed that beta-catenin protein is stabilized by a mechanism involving FAM83H in osteosarcoma tumors.

2. Beta-catenin is a part of a positive feedback loop, which sustains a high Tspan8 expression level, conferring to melanoma cells the invasive properties required for tumor progression and dissemination.

3. RSPO3 exhibited a tumor-promoting effect in bladder cancer cells through activation of Wnt/beta-catenin and Hedgehog signaling pathways.

4. NHERF1 inhibits Wnt signaling-mediated proliferation of cervical cancer via suppression of ACTN4, and NHERF1 downregulation may contribute to the progression of cervical cancer.

5. UBE2S mediates tumor progression via SOX6/beta-Catenin signaling in endometrial cancer

6. beta-catenin is highly expressed in skin lesions of patients with scleroderma

7. Circ-CTNNB1 bound DEAD-box polypeptide 3 (DDX3) to facilitate its physical interaction with transcription factor Yin Yang 1 (YY1), resulting in the transactivation of YY1 and transcriptional alteration of downstream genes associated with beta-catenin activation and cancer progression.

8. Data indicate that activation of beta-catenin-dependent signaling in chronic lung disease leads to changes in mucus and ciliated cell frequency and that P300 and CBP tune the beta-catenin signal to favor mucus cell differentiation.

9. P1 promoter-driven HNF4A isoform expression was found to be repressed by beta-catenin.

10. we found that the mechanism behind the TRIM32-promoted GC progression was related to the b-catenin signalling pathway. Collectively, these data suggest that TRIM32 promotes GC cell proliferation, migration, and invasion by activating the b-catenin signalling pathway.

11. DSCR8 activates Wnt/beta-catenin signal pathway to promote HCC progression by DSCR8/miR-485-5p/FZD7 axis.

12. Based on gene and protein expression analysis, NK-lysin decreased beta-catenin and MMP-2 expression. These results suggested that NK-lysin has anti-invasion and antimetastatic effects on hepatocellular carcinoma cells in vitro by reducing the level of the beta-catenin and MMP-2

13. Ube2s-promoted beta-Catenin accumulation partially released the dependence on exogenous molecules for the process of embryonic stem (ES) cell differentiation into mesoendoderm lineages.

14. no association existed between beta-arrestins and sst2, sst5 or D2 expression, nor with response to somatostatin receptor ligands or tumour invasiveness.

15. DAX1 transcriptionally repressed GSK3beta, an inhibitor of the Wnt/beta-catenin pathway, by physically interacting with -666~-444 motif on the GSK3beta promoter.

16. RT-PCR and Western blot assay results showed that the expression levels of beta-catenin mRNA and protein in keloid pathological scar tissue were significantly higher than those in adjacent normal tissue

17. Study shows that IKKbeta promotes adipogenesis but inhibits osteogenesis in murine and human mesenchymal stem cells (MSCs) through an NF-kappaB-independent mechanism. IKKbeta is a beta-catenin kinase that phosphorylates the degron motif of beta-catenin to prime it for beta-TrCP-mediated ubiquitination and degradation, thereby regulating MSC fate.

18. We documented core sequence-specific transcriptional upregulation of several b-catenin downstream target genes associated with cell proliferation and malignant transformation, fibrogenesis or fat accumulation. The extent of b-catenin nuclear translocation varied in accordance with b-catenin downstream gene upregulation in infected cells.

19. circZFR may exert carcinogenic role in HCC through regulating miR-3619-5p/CTNNB1 axis and activating Wnt/beta-catenin pathway

20. High CTNNB1 expression is associated with Glioma Tumorigenesis.

Pig (Porcine) Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. In this study, animal experimentation verified that the canonical Wnt/beta-catenin signaling pathway was activated under a reduced activity of p-beta-catenin (Ser33/37/Thr41) and an increased accumulation of beta-catenin in the lungs and kidneys of pigs infected with a highly virulent strain of Haemophilus parasuis.

2. Results highlight a potential role for the beta-catenin/Wnt and Notch signalling pathways during the infection of crypt cells by L. intracellularis.

3. Flutamide exposure led to decreased beta-catenin in corpus luteum of mid/late pregnancy.

4. beta-catenin signaling is involved in formation of contractile membranes by dedifferentiated retinal pigment epithelium cells.

5. Wnt3a produced a significant increase in heart valve interstitial cell number at day 4 and in the percentage of BrdU-positive nuclei at 24 h. The increase in proliferation was abolished by beta-catenin siRNA.

6. This study tested whether prenatal and neonatal exposure to antiandrogen flutamide affected ovarian 17beta-estradiol synthesis and the associated gene expression in large antral follicles of adult pigs.

7. beta-catenin controls myocardin-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes

8. beta-Catenin plays a critical role in mediating TGF-beta1-induced myofibroblast differentiation in aortic valve interstitial cells.

9. scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of Glycogen synthase kinase 3beta activity which can lead to activation of the downstream signaling through beta-catenin

10. Data show that Wnt3a can inhibit the adipogenic differentiation of porcine AMSCs, and suggest that Wnt/beta-catenin signaling inhibits adipogenic differentiation potential and alters the cell fate from adipocytes to osteoblasts.

11. TNF-alpha inhibits adipogenesis through stabilization of beta-catenin protein in porcine preadipocytes.

Cow (Bovine) Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. Bovine herpesvirus 1 transiently increased beta-catenin protein levels in bovine kidney cells, but not in rabbit skin cells.

2. These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.

3. beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves.

4. These data demonstrate for the first time that FSH regulates CTNNB1 protein and WNT2 mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT signaling in ovarian steroidogenesis and follicular growth of cattle.

5. These data provide evidence that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin-targeted genes and myogenesis in the muscle-derived stem cells of cattle.

6. that beta-catenin is a plasma membrane-associated protein in airway smooth muscle that regulates active tension development, presumably by stabilizing cell-cell contacts and thereby supporting force transmission between neighboring cells.

7. This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin.

8. TGF-beta3 induces the chondrogenic differentiation of pericytes by inducing Wnt/beta-catenin signaling and T-cell factor-induced gene transcription.

9. cAMP/PKA regulation of GSK3beta/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.

Rabbit Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. Palmatin effect on osteoarthritis is likely mediated via the Wnt/beta-catenin and Hedgehog signaling

2. These results collectively showed that 2-Deoxy-D-glucose regulates dedifferentiation via beta-catenin pathway in rabbit articular chondrocytes.