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anti-Mouse (Murine) CTNNB1 Antibodies:
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Human Polyclonal CTNNB1 Primary Antibody for CyTOF, FACS - ABIN4899451
Sáenz-Morales, Escribese, Stamatakis, García-Martos, Alegre, Conde, Pérez-Sala, Mampaso, García-Bermejo: Requirements for proximal tubule epithelial cell detachment in response to ischemia: role of oxidative stress. in Experimental cell research 2006
Show all 13 Pubmed References
Human Monoclonal CTNNB1 Primary Antibody for WB - ABIN1882227
Huang, Wang, Guo, Jia, Lin, Li, Wang, Chen: Approaching the intrinsic electron field-emission of a graphene film consisting of quasi-freestanding graphene strips. in Small (Weinheim an der Bergstrasse, Germany) 2011
Show all 5 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for WB - ABIN1881236
Huang, Zhou, Saberwal, Konieczna, Horvath, Katsoulidis, Platanias, Eklund: Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription. in Molecular and cellular biology 2010
Show all 5 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for WB - ABIN1881237
Chairoungdua, Smith, Pochard, Hull, Caplan: Exosome release of ?-catenin: a novel mechanism that antagonizes Wnt signaling. in The Journal of cell biology 2010
Show all 5 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for FACS, IF - ABIN1881238
Mirza, Sun, Zhao, Potula, Frey, Vogel, Malik, Zhao: FoxM1 regulates re-annealing of endothelial adherens junctions through transcriptional control of beta-catenin expression. in The Journal of experimental medicine 2010
Show all 5 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for FACS, IF - ABIN1881239
Teng, Wang, Wang, Wang: [Effect of siRNA-mediated beta-catenin gene on Wnt signal pathway in lung adenocarcinoma A549 cell]. in Zhonghua yi xue za zhi 2010
Show all 5 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for EIA, IF - ABIN951058
Guo, Shen, Liao, Lian, Wang: NGX6 inhibits cell invasion and adhesion through suppression of Wnt/beta-catenin signal pathway in colon cancer. in Acta biochimica et biophysica Sinica 2010
Show all 4 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for ICC, IHC (fro) - ABIN3044344
Zhao, Li, Gao, Wang, Yan, Zhan, Liu, Mao, Chen, Wang et al.: Design, synthesis and biological evaluation of N-alkyl or aryl substituted isoindigo derivatives as potential dual cyclin-dependent kinase 2 (CDK2)/glycogen synthase kinase 3? (GSK-3?) ... in European journal of medicinal chemistry 2014
Show all 3 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for ICC, IHC (fro) - ABIN5518651
Hao, Wen, Li, Wang, Ni, Wang, Wang, Sun, Fan, Mao: LiCl inhibits PRRSV infection by enhancing Wnt/?-catenin pathway and suppressing inflammatory responses. in Antiviral research 2015
Show all 3 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for ELISA, IHC - ABIN1584165
Chen, Chian, Hsiao: Mucin-producing urothelial-type adenocarcinoma of the prostate as a mimicker of colonic adenocarcinoma: a case report and review of the literature. in International journal of surgical pathology 2012
Show all 2 Pubmed References
temporal expression of CTNNB1 mRNA during dermal wound repair in the horse
findings indicate that beta-catenin signaling plays a critical role in postnatal bone remodeling. Our study provides new insights into the regulation of epiphyseal bone homeostasis at postnatal stage
Study validates the DNAJB1 (show DNAJB1 Antibodies)-PRKACA (show PRKACA Antibodies) fusion kinase as an oncogenic driver and candidate drug target for fibrolamellar hepatocellular carcinoma in mouse model in which tumorigenesis was significantly enhanced by genetic activation of beta-catenin.
BCAS2 (show BCAS2 Antibodies) is an upstream regulator of beta-catenin gene expression and plays a role in dendrite growth at least partly through beta-catenin in the forebrain.
LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose-induced podocyte injury via its interplay with beta-catenin and SRSF1 (show SRSF1 Antibodies).
These findings suggest a suppressive function for Ctbp2 (show CTBP2 Antibodies) in reducing the protein level of beta-catenin, along with priming its position on core pluripotency genes to hinder beta-catenin deposition, which is central to commitment to the appropriate lineage.
Beta-catenin deletion in cathepsin K (CtsK (show CTSK Antibodies))-expressing cells causes a severe loss of bone mass.
the GSK-3beta/beta-catenin signal pathway mediates the adverse effects of Ti particles on osteoblast differentiation and bone destruction
HIV and drug abuse mediate astrocyte senescence in a beta (show SUCLA2 Antibodies)-catenin-dependent manner leading to neuronal toxicity.
The absence of hepatic beta-catenin predisposes mice to hepatic injury and fibrosis following iron overload, which was reminiscent of hemochromatosis (show HFE Antibodies) and associated with enhanced steatohepatitis and fibrosis.
beta-catenin and p65 (show NFkBP65 Antibodies) are activated in separate cellular compartments during liver regeneration, with p65 (show NFkBP65 Antibodies) activity in nonparenchymal compartment contributing to the activation of hepatocyte beta-catenin, cyclin D1 (show CCND1 Antibodies) expression, and subsequent proliferation
The results demonstrate that the argon plasma jet (show FBXL15 Antibodies) has no adverse effects on fin regeneration and embryogenesis in zebrafish, and does not interrupt the (Wnt (show WNT2 Antibodies))/beta-Catenin-signaling pathways.
The expression of c-kit and beta-catenin suggests that erythropoietin (show EPO Antibodies) may exert a role in regeneration reducing the extent of tubular damage from the outset after gentamicin administration.
Net1-regulated beta-catenin activation plays a crucial role in the dorsal axis formation during zebrafish development.
Wnt (show WNT2 Antibodies)/beta-catenin signaling induces expression of col12a1a/b and deposition of Collagen XII, which is necessary for axons to actively navigate the non-neural lesion site environment.
Mechanistically, Hif-3alpha2 binds to beta-catenin and destabilizes the nuclear beta-catenin complex.
Nuclear beta-catenin is an indication of an activated Wnt (show WNT2 Antibodies) pathway, therefore suggesting a possible role for Wnt (show WNT2 Antibodies) signalling during zebrafish tooth development and replacement.
Findings suggest that microRNA 19b (miR (show MYLIP Antibodies)-19b) regulates laterality development and heart looping in embryos by targeting beta-catenin ctnnb1.
Custos binds to beta-catenin in a Wnt (show WNT2 Antibodies) responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.
The role of the beta-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila.
The Wnt (show WNT2 Antibodies)/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality. (Review)
We identified the amphibian leap2 (show LEAP2 Antibodies) gene which is highly related to its mammalian orthologues at both structural and sequence levels. The gene is expressed in the embryo mostly in the endoderm-derived tissues. Accordingly it is induced in pluripotent animal cap cells by FGF, activin (show Actbeta Antibodies) or a combination of vegT/beta-catenin.
Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A (show PPP2R2B Antibodies) and thereby down-regulating the Wnt (show WNT2 Antibodies)/beta-catenin signaling.
maternal Wnt (show WNT2 Antibodies)/STOP signaling, but not beta-catenin signaling, has a role in cleavage after fertilization and cell cycle progression
Wnt (show WNT2 Antibodies) signalling can benefit from nucleo-cytoplasmic shuttling of APC (show APC Antibodies), Axin (show AXIN1 Antibodies) and GSK3, although they are in general beta-catenin antagonising proteins.
Phosphoinositide 3-kinase and Rac (show AKT1 Antibodies) polarization depend specifically on the N-cadherin (show CDH2 Antibodies)-p120 catenin (show CTNND1 Antibodies) complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin (show CDH2 Antibodies)-beta-catenin complex.
HERG (show KCNH2 Antibodies) channel activity is stimulated by beta-catenin
Zic3 (show ZIC3 Antibodies) can suppress Wnt (show WNT2 Antibodies)/beta-catenin signaling and control development of the notochord and Spemann's organizer.
Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3
The tyrosine kinase receptor (show KDR Antibodies), PTK7 (show PTK7 Antibodies), is implicated in beta-catenin-dependent developmental processes.
CTNNB1 mutation is associated with acquired resistance to KIT inhibitor in metastatic melanoma.
three CTNNB1 SNPs were suggested to have the potential to be novel biomarkers for risk prediction of cancer in overall population or some specific subgroups. [Review]
A CTNNB1 exon 3 mutation restricted to the areas exhibiting both positive glutamine synthetase (GS (show GLUL Antibodies)) and C-reactive protein (CRP (show CRP Antibodies)) expression, whereas wild-type CTNNB1 was found in areas showing only CRP (show CRP Antibodies) staining. These two cases illustrate focal beta-catenin activation that can occur within Inflammatory hepatocellular adenoma (IHCAs).
Results show that E-cadherin (show CDH1 Antibodies)/beta-catenin complex is disrupted by ICAT (show CTNNBIP1 Antibodies) promoting epithelial-mesenchymal transition of cervical cancer cells.
Toosendanin administration inhibited growth and liver metastasis of orthotopically implanted SGC7901 tumors in vivo through miR200amediated beta-catenin pathway. Our data suggest that Toosendanin may suppress oncogenic phenotypes of human GC cells partly via miR200a/beta-catenin axis. Hence, Toosendanin may have a promising chemotherapeutic activity for GC therapy.
High CTNNB1 expression is associated with papillary thyroid carcinoma.
we found that CypA (show PPIA Antibodies) binds beta-catenin and is recruited to Wnt (show WNT2 Antibodies) target gene promoters. By increasing the interaction between beta-catenin and TCF4 (show TCF4 Antibodies), CypA (show PPIA Antibodies) enhances transcriptional activity. Our results demonstrate that CypA (show PPIA Antibodies) enhances GIC stemness, self-renewal, and radioresistance through Wnt (show WNT2 Antibodies)/beta-catenin signaling
Treatment of a xenograft model of a CTNNB1-mutant cell line with the TTK inhibitor NTRC 0066-0 resulted in complete inhibition of tumor growth. Mutations in CTNNB1 occur at relatively high frequency in endometrial cancer and hepatocellular carcinoma, which are known to express high TTK levels. We propose mutant CTNNB1 as a prognostic drug response biomarker, enabling the selection of patients most likely to respond to TTK
results indicated that miR (show MLXIP Antibodies)-590-3p activates the Wnt (show WNT2 Antibodies)/beta-catenin signaling pathway
High CTNNB1 expression is associated with cervical cancer tumorigenesis and metastasis.
Results highlight a potential role for the beta-catenin/Wnt (show WNT2 Antibodies) and Notch (show NOTCH1 Antibodies) signalling pathways during the infection of crypt cells by L. intracellularis.
Flutamide exposure led to decreased beta-catenin in corpus luteum of mid/late pregnancy.
beta-catenin signaling is involved in formation of contractile membranes by dedifferentiated retinal pigment epithelium cells.
Wnt3a (show WNT3A Antibodies) produced a significant increase in heart valve interstitial cell number at day 4 and in the percentage of BrdU-positive nuclei at 24 h. The increase in proliferation was abolished by beta-catenin siRNA.
beta-catenin controls myocardin (show MYOCD Antibodies)-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes
beta-Catenin plays a critical role in mediating TGF-beta1 (show TGFB1 Antibodies)-induced myofibroblast differentiation in aortic valve interstitial cells.
scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of Glycogen synthase kinase 3beta activity which can lead to activation of the downstream signaling through beta-catenin
Data show that Wnt3a (show WNT3A Antibodies) can inhibit the adipogenic differentiation of porcine AMSCs, and suggest that Wnt (show WNT2 Antibodies)/beta-catenin signaling inhibits adipogenic differentiation potential and alters the cell fate from adipocytes to osteoblasts.
TNF-alpha (show TNF Antibodies) inhibits adipogenesis through stabilization of beta-catenin protein in porcine preadipocytes.
Bovine herpesvirus 1 transiently increased beta-catenin protein levels in bovine kidney cells, but not in rabbit skin cells.
These results demonstrate that activation of AKT (show AKT1 Antibodies) is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.
beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves.
These data demonstrate for the first time that FSH (show BRD2 Antibodies) regulates CTNNB1 protein and WNT2 (show WNT2 Antibodies) mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT (show WNT2 Antibodies) signaling in ovarian steroidogenesis and follicular growth of cattle.
These data provide evidence that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin-targeted genes and myogenesis in the muscle-derived stem cells of cattle.
that beta-catenin is a plasma membrane-associated protein (show PDZK1IP1 Antibodies) in airway smooth muscle that regulates active tension development, presumably by stabilizing cell-cell contacts and thereby supporting force transmission between neighboring cells.
This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin.
TGF-beta3 (show TGFB3 Antibodies) induces the chondrogenic differentiation of pericytes by inducing Wnt (show WNT2 Antibodies)/beta-catenin signaling and T-cell factor-induced gene transcription.
cAMP/PKA regulation of GSK3beta/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.
Palmatin effect on osteoarthritis is likely mediated via the Wnt (show WNT2 Antibodies)/beta-catenin and Hedgehog (show SHH Antibodies) signaling
These results collectively showed that 2-Deoxy-D-glucose regulates dedifferentiation via beta-catenin pathway in rabbit articular chondrocytes.
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
catenin beta 1 subunit
, catenin beta-1
, beta catenin 1
, catenin (cadherin-associated protein), beta 1, 88kDa
, catenin beta-1-like
, catenin (cadherin associated protein), beta 1, 88kDa
, catenin beta
, beta catenin