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anti-Mouse (Murine) CTNNB1 Antibodies:
anti-Rat (Rattus) CTNNB1 Antibodies:
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Human Polyclonal CTNNB1 Primary Antibody for CyTOF, FACS - ABIN4899451
Sáenz-Morales, Escribese, Stamatakis, García-Martos, Alegre, Conde, Pérez-Sala, Mampaso, García-Bermejo: Requirements for proximal tubule epithelial cell detachment in response to ischemia: role of oxidative stress. in Experimental cell research 2006
Show all 10 Pubmed References
Human Monoclonal CTNNB1 Primary Antibody for WB - ABIN1882227
Huang, Wang, Guo, Jia, Lin, Li, Wang, Chen: Approaching the intrinsic electron field-emission of a graphene film consisting of quasi-freestanding graphene strips. in Small (Weinheim an der Bergstrasse, Germany) 2011
Show all 5 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for FACS, IF - ABIN1881238
Huang, Zhou, Saberwal, Konieczna, Horvath, Katsoulidis, Platanias, Eklund: Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription. in Molecular and cellular biology 2010
Show all 5 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for FACS, IF - ABIN1881239
Chairoungdua, Smith, Pochard, Hull, Caplan: Exosome release of ?-catenin: a novel mechanism that antagonizes Wnt signaling. in The Journal of cell biology 2010
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Human Polyclonal CTNNB1 Primary Antibody for WB - ABIN1881236
Mirza, Sun, Zhao, Potula, Frey, Vogel, Malik, Zhao: FoxM1 regulates re-annealing of endothelial adherens junctions through transcriptional control of beta-catenin expression. in The Journal of experimental medicine 2010
Show all 5 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for WB - ABIN1881237
Teng, Wang, Wang, Wang: [Effect of siRNA-mediated beta-catenin gene on Wnt signal pathway in lung adenocarcinoma A549 cell]. in Zhonghua yi xue za zhi 2010
Show all 5 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for EIA, IF - ABIN951058
Guo, Shen, Liao, Lian, Wang: NGX6 inhibits cell invasion and adhesion through suppression of Wnt/beta-catenin signal pathway in colon cancer. in Acta biochimica et biophysica Sinica 2010
Show all 4 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for ICC, IHC (fro) - ABIN3044344
Zhao, Li, Gao, Wang, Yan, Zhan, Liu, Mao, Chen, Wang et al.: Design, synthesis and biological evaluation of N-alkyl or aryl substituted isoindigo derivatives as potential dual cyclin-dependent kinase 2 (CDK2)/glycogen synthase kinase 3? (GSK-3?) ... in European journal of medicinal chemistry 2014
Show all 3 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for ICC, IHC (fro) - ABIN5518651
Hao, Wen, Li, Wang, Ni, Wang, Wang, Sun, Fan, Mao: LiCl inhibits PRRSV infection by enhancing Wnt/?-catenin pathway and suppressing inflammatory responses. in Antiviral research 2015
Show all 3 Pubmed References
Human Polyclonal CTNNB1 Primary Antibody for ELISA, IHC - ABIN1584165
Chen, Chian, Hsiao: Mucin-producing urothelial-type adenocarcinoma of the prostate as a mimicker of colonic adenocarcinoma: a case report and review of the literature. in International journal of surgical pathology 2012
Show all 2 Pubmed References
temporal expression of CTNNB1 mRNA during dermal wound repair in the horse
Cardiomyocyte hypertrophy is blunted with cardiac fibroblast-specific loss of beta-catenin after trans-aortic constriction in vivo.
These results collectively suggest that sustained activation of Wnt (show WNT2 Antibodies)/beta-catenin signaling in endothelial cells might be a cause of heart failure through suppressing neuregulin-ErbB (show EGFR Antibodies) signaling.
Our findings indicate that H2O2 inhibits NaV1.5 (show SCN5A Antibodies) expression by activating the Wnt/b-catenin signaling and beta-catenin interacts with TCF4 (show TCF4 Antibodies) to transcriptionally suppress cardiac NaV1.5 (show SCN5A Antibodies) expression.
TGF-beta (show TGFB1 Antibodies) and beta-catenin crosstalk in proximal tubules may have a role in tubular injury in two models of chronic kidney disease
Results indicate that ablation of epithelial Wnt (show WNT2 Antibodies)/beta-catenin signaling affected epididymal epithelial cell proliferation but did not inhibit cell differentiation.
Interactions between the Wnt (show WNT2 Antibodies)/beta-catenin and the Kras/ERK (show EPHB2 Antibodies)/Foxm1 (show FOXM1 Antibodies) pathways are essential to restrict SOX9 (show SOX9 Antibodies) expression in basal cells during pulmonary branching morphogenesis
The collective results indicate that the osteoanabolic response to loading can occur on the periosteal surface when beta-cat levels are significantly reduced in Dmp1 (show DMP1 Antibodies)-expressing cells.
L. donovani triggered AKT (show AKT1 Antibodies) activation to regulate GSK-3beta (show GSK3b Antibodies)/beta-catenin/FOXO-1 (show FOXO1 Antibodies) axis.
Barx2 (show BARX2 Antibodies) and Pax7 (show PAX7 Antibodies) regulate the canonical Wnt (show WNT2 Antibodies) target gene Axin2 (show AXIN2 Antibodies), which mediates critical feedback to terminate the transcriptional response to Wnt (show WNT2 Antibodies) signals.
NFkB/beta-catenin signaling pathway plays a key role in the regulation of breast cancer-induced bone cell activity and osteolysis.
Net1-regulated beta-catenin activation plays a crucial role in the dorsal axis formation during zebrafish development.
Wnt (show WNT2 Antibodies)/beta-catenin signaling induces expression of col12a1a/b and deposition of Collagen XII, which is necessary for axons to actively navigate the non-neural lesion site environment.
Mechanistically, Hif-3alpha2 binds to beta-catenin and destabilizes the nuclear beta-catenin complex.
Nuclear beta-catenin is an indication of an activated Wnt (show WNT2 Antibodies) pathway, therefore suggesting a possible role for Wnt (show WNT2 Antibodies) signalling during zebrafish tooth development and replacement.
Findings suggest that microRNA 19b (miR (show MYLIP Antibodies)-19b) regulates laterality development and heart looping in embryos by targeting beta-catenin ctnnb1.
Custos binds to beta-catenin in a Wnt (show WNT2 Antibodies) responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.
The role of the beta-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila.
The Wnt (show WNT2 Antibodies)/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality. (Review)
This study demonstrated that beta-catenin/Wnt (show WNT2 Antibodies) signaling is initially required to activate cell-cycle re-entry in Muller glia following injury and that Wnt (show WNT2 Antibodies) signaling subsequently controls the fate of the progeny of those cell divisions.
A novel role for Eaf1 (show EAF1 Antibodies) and Eaf2 (show EAF2 Antibodies) in inhibiting canonical Wnt (show WNT2 Antibodies)/beta-catenin signaling, which might form the mechanistic basis for Eaf1 (show EAF1 Antibodies) and Eaf2 (show EAF2 Antibodies) tumor suppressor activity.
We identified the amphibian leap2 (show LEAP2 Antibodies) gene which is highly related to its mammalian orthologues at both structural and sequence levels. The gene is expressed in the embryo mostly in the endoderm-derived tissues. Accordingly it is induced in pluripotent animal cap cells by FGF, activin (show Actbeta Antibodies) or a combination of vegT/beta-catenin.
Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A (show PPP2R2B Antibodies) and thereby down-regulating the Wnt (show WNT2 Antibodies)/beta-catenin signaling.
maternal Wnt (show WNT2 Antibodies)/STOP signaling, but not beta-catenin signaling, has a role in cleavage after fertilization and cell cycle progression
Wnt (show WNT2 Antibodies) signalling can benefit from nucleo-cytoplasmic shuttling of APC (show APC Antibodies), Axin (show AXIN1 Antibodies) and GSK3 (show GSK3b Antibodies), although they are in general beta-catenin antagonising proteins.
Phosphoinositide 3-kinase and Rac (show AKT1 Antibodies) polarization depend specifically on the N-cadherin (show CDH2 Antibodies)-p120 catenin (show CTNND1 Antibodies) complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin (show CDH2 Antibodies)-beta-catenin complex.
HERG (show KCNH2 Antibodies) channel activity is stimulated by beta-catenin
Zic3 (show ZIC3 Antibodies) can suppress Wnt (show WNT2 Antibodies)/beta-catenin signaling and control development of the notochord and Spemann's organizer.
Notch (show NOTCH1 Antibodies) initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3 (show GSK3b Antibodies)
The tyrosine kinase receptor (show KDR Antibodies), PTK7 (show PTK7 Antibodies), is implicated in beta-catenin-dependent developmental processes.
Data indicate cross-talks between MYCN (show MYCN Antibodies) and beta-catenin signalling, which repress normal beta-catenin mediated transcriptional regulation.
mutations in TERT (show TERT Antibodies) promoter and in CTNNB1 gene represent specific cancer signatures in the pathogenesis of viral related HCC (show FAM126A Antibodies).
Multiple myeloma that is driven by deregulated iron homeostasis and/or Pyk2 (show PTK2B Antibodies)/beta-cateninn signaling is susceptible to deferasirox-induced apoptosis.
Results indicate that protein disulfide isomerase family 6 (PDIA6) overexpression promoted the proliferation of HeLa cells by suppressing the phosphorylation of beta-catenin, thereby inhibiting the degradation of beta-catenin through the ubiquitin-proteasome pathway.
Results indicate that SFRP1 (show SFRP1 Antibodies) rs7832767 C > T, CTNNB1 rs2293303 C > T, and WISP1 (show WISP1 Antibodies) rs16893344 C > T were all strongly correlated with myocardial infarction (MI) susceptibility.
Data suggest that casein kinase 2 (CK2 (show CSNK2A1 Antibodies)) inhibition is a promising approach to blocking beta-catenin in MPNST cells, although combinatorial therapies may be required for maximal efficacy.
Beta-catenin knockdown inhibited cell proliferation, promoted apoptosis and suppressed cell migration in A549 and H460 cells accompanied by the decreased expression of Myc (show MYC Antibodies), PCNA (show PCNA Antibodies), VEGF (show VEGFA Antibodies), CD44 (show CD44 Antibodies), MMP-9 (show MMP9 Antibodies), MMP-13 (show MMP13 Antibodies) and activated bax (show BAX Antibodies)/caspase-3 (show CASP3 Antibodies) pathway.
Integrin alphavbeta3 (show ITGAV Antibodies) has a role in enhancing beta-catenin signaling in acute myeloid leukemia (show BCL11A Antibodies) harboring Fms-like tyrosine kinase-3 (show FLT3 Antibodies) internal tandem duplication mutations
lncRNA-BCAT1 (show BCAT1 Antibodies) is a tumor suppressor and that lncRNA-BCAT1 (show BCAT1 Antibodies) may be an effective prognostic biomarker in Colorectal cancer.
Enhancer of zeste homolog 2 (EZH2 (show EZH2 Antibodies)) expression is positively correlated with the expression of Wnt (show WNT2 Antibodies)/beta-catenin signaling and negatively correlated with the expression of GSK-3beta (show GSK3b Antibodies) and TP53 (show TP53 Antibodies) in cervical cancer tissues.
Results highlight a potential role for the beta-catenin/Wnt (show WNT2 Antibodies) and Notch (show NOTCH1 Antibodies) signalling pathways during the infection of crypt cells by L. intracellularis.
Flutamide exposure led to decreased beta-catenin in corpus luteum of mid/late pregnancy.
beta-catenin signaling is involved in formation of contractile membranes by dedifferentiated retinal pigment epithelium cells.
Wnt3a (show WNT3A Antibodies) produced a significant increase in heart valve interstitial cell number at day 4 and in the percentage of BrdU-positive nuclei at 24 h. The increase in proliferation was abolished by beta-catenin siRNA.
beta-catenin controls myocardin (show MYOCD Antibodies)-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes
beta-Catenin plays a critical role in mediating TGF-beta1 (show TGFB1 Antibodies)-induced myofibroblast differentiation in aortic valve interstitial cells.
scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of Glycogen synthase kinase 3beta activity which can lead to activation of the downstream signaling through beta-catenin
Data show that Wnt3a (show WNT3A Antibodies) can inhibit the adipogenic differentiation of porcine AMSCs, and suggest that Wnt (show WNT2 Antibodies)/beta-catenin signaling inhibits adipogenic differentiation potential and alters the cell fate from adipocytes to osteoblasts.
TNF-alpha (show TNF Antibodies) inhibits adipogenesis through stabilization of beta-catenin protein in porcine preadipocytes.
Bovine herpesvirus 1 transiently increased beta-catenin protein levels in bovine kidney cells, but not in rabbit skin cells.
These results demonstrate that activation of AKT (show AKT1 Antibodies) is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.
beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves.
These data demonstrate for the first time that FSH (show BRD2 Antibodies) regulates CTNNB1 protein and WNT2 (show WNT2 Antibodies) mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT (show WNT2 Antibodies) signaling in ovarian steroidogenesis and follicular growth of cattle.
These data provide evidence that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin-targeted genes and myogenesis in the muscle-derived stem cells of cattle.
that beta-catenin is a plasma membrane-associated protein (show PDZK1IP1 Antibodies) in airway smooth muscle that regulates active tension development, presumably by stabilizing cell-cell contacts and thereby supporting force transmission between neighboring cells.
This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin.
TGF-beta3 (show TGFB3 Antibodies) induces the chondrogenic differentiation of pericytes by inducing Wnt (show WNT2 Antibodies)/beta-catenin signaling and T-cell factor-induced gene transcription.
cAMP/PKA regulation of GSK3beta (show GSK3b Antibodies)/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.
Palmatin effect on osteoarthritis is likely mediated via the Wnt (show WNT2 Antibodies)/beta-catenin and Hedgehog (show SHH Antibodies) signaling
These results collectively showed that 2-Deoxy-D-glucose regulates dedifferentiation via beta-catenin pathway in rabbit articular chondrocytes.
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
catenin beta 1 subunit
, catenin beta-1
, beta catenin 1
, catenin (cadherin-associated protein), beta 1, 88kDa
, catenin beta-1-like
, catenin (cadherin associated protein), beta 1, 88kDa
, catenin beta
, beta catenin