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Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
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3.2802167 | ABIN2792526 | WB | Rabbit | N-Term | Log in to see | Polyclonal | 1 | |||
3.2802167 | ABIN2792528 | ChIP WB | Rabbit | C-Term | Log in to see | Polyclonal | 0 | |||
3.2802167 | ABIN2792303 | IHC WB | Rabbit | C-Term | Log in to see | Polyclonal | 1 | |||
3.2802167 | ABIN126747 | EIA IF IHC (p) IP WB | Mouse | IgG1 | Exon 3 | Log in to see | 9G2 | 0 | ||
3.2802167 | ABIN126742 | WB | Mouse | IgG1 | pTyr654 | Log in to see | 1B11 | 0 | ||
3.2802167 | ABIN2454170 | FACS IHC WB | Mouse | IgG2b | Log in to see | 9H2 | 0 | |||
3.2802167 | ABIN2454136 | FACS IF IHC WB | Mouse | IgG2a | Log in to see | 1E10 | 0 | |||
3.2802167 | ABIN2454137 | FACS WB | Mouse | IgG2a | Log in to see | 6E7 | 0 | |||
3.2802167 | ABIN2454138 | FACS IF WB | Mouse | IgG1 | Log in to see | 12C1 | 0 | |||
3.2802167 | ABIN2452237 | WB | Mouse | IgG1 | AA 531-781 | Log in to see | 2D11 | 0 | ||
3.2802167 | ABIN2452306 | WB | Mouse | IgG2a | AA 531-781 | Log in to see | 2H3 | 0 | ||
3.2802167 | ABIN2452315 | IHC WB | Mouse | IgG2a | AA 531-781 | Log in to see | 1F3 | 0 | ||
3.2802167 | ABIN2463774 | IHC ELISA WB | Rabbit | Log in to see | Polyclonal | 0 | ||||
3.2802167 | ABIN2562060 | ELISA WB | Goat | IgG | Log in to see | Polyclonal | 0 | |||
1 | ABIN1496890 | FACS IF IHC (p) WB | Mouse | IgG2a | Log in to see | 9F6 | 0 | |||
1 | ABIN1496888 | FACS IF IHC (p) WB | Mouse | IgG2a | Log in to see | 1E10 | 0 | |||
1 | ABIN1496902 | WB | Mouse | IgG1 | AA 531-781 | Log in to see | 2D11 | 0 | ||
1 | ABIN1496892 | FACS IF WB | Mouse | IgG1 | Log in to see | 12C1 | 0 | |||
1 | ABIN1496891 | FACS IF WB | Mouse | IgG2a | Log in to see | 2F6 | 0 | |||
1 | ABIN1496898 | IF IHC (p) WB | Mouse | IgG2b | Log in to see | 9C1 | 0 |
General |
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Antigen | Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) Antibodies |
Epitope | C-Term Alternatives |
Reactivity | Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Zebrafish (Danio rerio) Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | This CTNNB1 antibody is un-conjugated Alternatives |
Application |
Chromatin Immunoprecipitation (ChIP), Western Blotting (WB)
Alternatives
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2 references available |
Supplier | Log in to see |
Product Details anti-CTNNB1 AntibodyTarget Details CTNNB1 Application Details Handling References for anti-CTNNB1 antibody (ABIN2792527) Images |
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Sequence | RTEPMAWNET ADLGLDIGAQ GEPLGYRQDD PSYRSFHSGG YGQDALGMDP |
Cross-Reactivity | Cow (Bovine), Dog (Canine), Chicken, Human, Mouse (Murine), Pig (Porcine), Rat (Rattus) |
Predicted Reactivity | Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Zebrafish: 100% |
Characteristics | This is a rabbit polyclonal antibody against CTNNB1. It was validated on Western Blot using a cell lysate as a positive control. |
Purification | Affinity Purified |
Immunogen | The immunogen is a synthetic peptide directed towards the C-terminal region of human CTNNB1 |
Target Details CTNNB1Product Details anti-CTNNB1 Antibody Application Details Handling References for anti-CTNNB1 antibody (ABIN2792527) Images back to top |
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Antigen | |
Alternative Name | CTNNB1 / Beta Catenin (CTNNB1 Antibody Abstract) |
Background |
Beta-catenin is an adherens junction protein. Adherens junctions (AJs, also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.Beta-catenin is an adherens junction protein. Adherens junctions (AJs, also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-54 DA216720.1 1-54 55-2626 X87838.1 1-2572 2627-3720 AC104307.2 83770-84863 Alias Symbols: CTNNB, DKFZp686D02253, FLJ25606, FLJ37923 Protein Interaction Partner: PPARD, PLA2G4A, FBXO45, BTRC, SUMO1, UBC, HUWE1, CDH5, CDH2, TCF4, TBL1X, SOX1, SKP1, RNF220, CACYBP, FBXW11, SUMO2, SIAH1, Apc2, COPS5, RNF14, CDH1, SP1, KCTD1, MDM2, UBE2B, GSK3B, NEK2, RBX1, PTGS2, STRN3, LATS2, APC, ELAVL1, AMOT, ABL1, AXIN1, CBL, LEF Protein Size: 781 |
Molecular Weight | 85 kDa |
Gene ID | 1499 |
NCBI Accession | NM_001904, NP_001895 |
UniProt | P35222 |
Pathways | WNT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2 |
Application DetailsProduct Details anti-CTNNB1 Antibody Target Details CTNNB1 Handling References for anti-CTNNB1 antibody (ABIN2792527) Images back to top |
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Application Notes |
WB Suggested Anti-CTNNB1 Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:62500 Positive Control: Human heart. Optimal working dilutions should be determined experimentally by the investigator. |
Comment |
Antigen size: 781 AA |
Restrictions | For Research Use only |
HandlingProduct Details anti-CTNNB1 Antibody Target Details CTNNB1 Application Details References for anti-CTNNB1 antibody (ABIN2792527) Images back to top |
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Format | Liquid |
Concentration | Lot specific |
Buffer | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose. |
Preservative | Sodium azide |
Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handling Advice | Avoid repeated freeze-thaw cycles. |
Storage | -20 °C |
Storage Comment | For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
References for anti-CTNNB1 antibody (ABIN2792527)Product Details anti-CTNNB1 Antibody Target Details CTNNB1 Application Details Handling Images back to top |
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Product cited in: |
Li, Yang, Tang, Zhang, Feng, Cui: "Repair of massively defected hemi-joints using demineralized osteoarticular allografts with protected cartilage." in: Journal of materials science. Materials in medicine, Vol. 26, Issue 8, pp. 227, 2015 |
Background publications |
Jiang, Tan, Li, Kivimäe, Yang, Zhuang, Lee, Chan, Stanton, Liu, Cheyette, Yu: "DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications." in: Cancer cell, Vol. 13, Issue 6, pp. 529-41, 2008 |
ImagesProduct Details anti-CTNNB1 Antibody Target Details CTNNB1 Application Details Handling References for anti-CTNNB1 antibody (ABIN2792527) back to top |
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Supplier Images |
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