anti-Cow (Bovine) FZD7 antibody for Immunohistochemistry

Recommended FZD7 Antibody (supplied by: Log in to see )

Antigen
Frizzled Family Receptor 7 (FZD7) Antibodies
  • Fz-7
  • Xfz7
  • frizzled-7
  • frizzled7
  • frz-7
  • frz7
  • fz7
  • fze3
  • FzE3
  • fzd7-a
  • fzd7-b
  • cFz-7
  • Fz7
  • frizzled class receptor 7
  • frizzled class receptor 7 L homeolog
  • cyclin-dependent kinase 15
  • FZD7
  • fzd7
  • fzd7.L
  • Cdk15
  • Fzd7
Epitope
C-Term
27
20
18
15
14
14
10
8
4
3
3
2
2
2
2
2
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus), Yeast (Saccharomyces cerevisiae)
138
113
29
9
9
9
7
7
6
3
2
1
1
Host
Rabbit
106
40
25
11
1
Clonality
Polyclonal
Conjugate
This FZD7 antibody is un-conjugated
11
6
5
5
5
4
4
4
3
3
3
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
117
68
29
24
18
14
10
5
3
2
1
Options
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Pubmed
6 references available

Available images

Western Blotting (WB) image for anti-Frizzled Family Receptor 7 (FZD7) (C-Term) antibody (ABIN2776708)
Immunohistochemistry (IHC) image for anti-Frizzled Family Receptor 7 (FZD7) (C-Term) antibody (ABIN2776708)
Western Blotting (WB) image for anti-Frizzled Family Receptor 7 (FZD7) (C-Term) antibody (ABIN2776708)
Catalog No. ABIN2776708
$ 289.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
9.067091 ABIN2469409 IHC ELISA Rabbit C-Term Log in to see Polyclonal 0
1 ABIN4312613 IHC IHC (p) Rabbit C-Term Log in to see Polyclonal 0

General

Antigen Frizzled Family Receptor 7 (FZD7) Antibodies
Epitope C-Term
(27), (20), (18), (15), (14), (14), (10), (8), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity Cow (Bovine), Dog (Canine), Guinea Pig, Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus), Yeast (Saccharomyces cerevisiae)
(138), (113), (29), (9), (9), (9), (7), (7), (6), (3), (2), (1), (1)
Host Rabbit
(106), (40), (25), (11), (1)
Clonality
Polyclonal
Conjugate This FZD7 antibody is un-conjugated
(11), (6), (5), (5), (5), (4), (4), (4), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (IHC), Western Blotting (WB)
(117), (68), (29), (24), (18), (14), (10), (5), (3), (2), (1)
Pubmed 6 references available
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Product Details anti-FZD7 Antibody

Target Details FZD7 Application Details Handling References for anti-FZD7 antibody (ABIN2776708) Images
Blocking Peptide Blocking peptide for this product available: ABIN977173
Sequence PDFTVFMIKY LMTMIVGITT GFWIWSGKTL QSWRRFYHRL SHSSKGETAV
Predicted Reactivity Cow: 100%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 82%
Characteristics This is a rabbit polyclonal antibody against FZD7. It was validated on Western Blot and immunohistochemistry.
Purification Affinity Purified
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human FZD7

Target Details FZD7

Product Details anti-FZD7 Antibody Application Details Handling References for anti-FZD7 antibody (ABIN2776708) Images back to top
Antigen
Alternative Name FZD7 (FZD7 Antibody Abstract)
Background FZD7 is 7-transmembrane domain protein that is receptor for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif.Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
Alias Symbols: FzE3
Protein Interaction Partner: UBC, UBQLN4, MAGI3, UBQLN1, DLG2, DLG4, DLG1,
Protein Size: 574
Molecular Weight 63 kDa
Gene ID 8324
NCBI Accession NM_003507, NP_003498
UniProt O75084
Pathways WNT Signaling, Stem Cell Maintenance

Application Details

Product Details anti-FZD7 Antibody Target Details FZD7 Handling References for anti-FZD7 antibody (ABIN2776708) Images back to top
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 574 AA
Restrictions For Research Use only

Handling

Product Details anti-FZD7 Antibody Target Details FZD7 Application Details References for anti-FZD7 antibody (ABIN2776708) Images back to top
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-FZD7 antibody (ABIN2776708)

Product Details anti-FZD7 Antibody Target Details FZD7 Application Details Handling Images back to top
Product cited in:

McIver, Stanger, Santarelli, Roman, Nixon, McLaughlin: "A unique combination of male germ cell miRNAs coordinates gonocyte differentiation." in: PLoS ONE, Vol. 7, Issue 4, pp. e35553, 2012

Schmuck, Warneke, Behrens, Simon, Weichert, Röcken: "Genotypic and phenotypic characterization of side population of gastric cancer cell lines." in: The American journal of pathology, Vol. 178, Issue 4, pp. 1792-804, 2011

Gökmen-Polar, Toroni, Hocevar, Badve, Zhao, Shen, Bruckheimer, Kinch, Miller: "Dual targeting of EphA2 and ER restores tamoxifen sensitivity in ER/EphA2-positive breast cancer." in: Breast cancer research and treatment, Vol. 127, Issue 2, pp. 375-84, 2011

Ohba, Lanigan, Roessler: "Leptin receptor JAK2/STAT3 signaling modulates expression of Frizzled receptors in articular chondrocytes." in: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, Vol. 18, Issue 12, pp. 1620-9, 2010

Ueno, Hiura, Suehiro, Hazama, Hirata, Oka, Imai, Dahiya, Hinoda: "Frizzled-7 as a potential therapeutic target in colorectal cancer." in: Neoplasia (New York, N.Y.), Vol. 10, Issue 7, pp. 697-705, 2008

Background publications

Vincan, Darcy, Smyth, Thompson, Thomas, Phillips, Ramsay: "Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth." in: Differentiation; research in biological diversity, Vol. 73, Issue 4, pp. 142-53, 2005

Images

Product Details anti-FZD7 Antibody Target Details FZD7 Application Details Handling References for anti-FZD7 antibody (ABIN2776708) back to top
Supplier Images
Western Blotting (WB) image for anti-Frizzled Family Receptor 7 (FZD7) (C-Term) antibody (ABIN2776708) WB Suggested Anti-FZD7 Antibody Titration: 0.2-1 ug/ml
Positive Control:...
Immunohistochemistry (IHC) image for anti-Frizzled Family Receptor 7 (FZD7) (C-Term) antibody (ABIN2776708) anti-Frizzled Family Receptor 7 (FZD7) (C-Term) antibody (Image 2)
Western Blotting (WB) image for anti-Frizzled Family Receptor 7 (FZD7) (C-Term) antibody (ABIN2776708) WB Suggested Anti-FZD7
Antibody Titration: 0.2-1 µg/mL
Positive Control...