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Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
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9.067091 | ABIN2469409 | IHC ELISA | Rabbit | C-Term | Log in to see | Polyclonal | 0 | |||
1 | ABIN4312613 | IHC IHC (p) | Rabbit | C-Term | Log in to see | Polyclonal | 0 |
General |
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Antigen | Frizzled Family Receptor 7 (FZD7) Antibodies |
Epitope | C-Term Alternatives |
Reactivity | Cow (Bovine), Dog (Canine), Guinea Pig, Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus), Yeast (Saccharomyces cerevisiae) Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | This FZD7 antibody is un-conjugated Alternatives |
Application |
Immunohistochemistry (IHC), Western Blotting (WB)
Alternatives
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6 references available |
Supplier | Log in to see |
Product Details anti-FZD7 AntibodyTarget Details FZD7 Application Details Handling References for anti-FZD7 antibody (ABIN2776708) Images |
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Blocking Peptide | Blocking peptide for this product available: ABIN977173 |
Sequence | PDFTVFMIKY LMTMIVGITT GFWIWSGKTL QSWRRFYHRL SHSSKGETAV |
Predicted Reactivity | Cow: 100%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 82% |
Characteristics | This is a rabbit polyclonal antibody against FZD7. It was validated on Western Blot and immunohistochemistry. |
Purification | Affinity Purified |
Immunogen | The immunogen is a synthetic peptide directed towards the C terminal region of human FZD7 |
Target Details FZD7Product Details anti-FZD7 Antibody Application Details Handling References for anti-FZD7 antibody (ABIN2776708) Images back to top |
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Antigen | |
Alternative Name | FZD7 (FZD7 Antibody Abstract) |
Background |
FZD7 is 7-transmembrane domain protein that is receptor for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif.Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. Alias Symbols: FzE3 Protein Interaction Partner: UBC, UBQLN4, MAGI3, UBQLN1, DLG2, DLG4, DLG1, Protein Size: 574 |
Molecular Weight | 63 kDa |
Gene ID | 8324 |
NCBI Accession | NM_003507, NP_003498 |
UniProt | O75084 |
Pathways | WNT Signaling, Stem Cell Maintenance |
Application DetailsProduct Details anti-FZD7 Antibody Target Details FZD7 Handling References for anti-FZD7 antibody (ABIN2776708) Images back to top |
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Application Notes | Optimal working dilutions should be determined experimentally by the investigator. |
Comment |
Antigen size: 574 AA |
Restrictions | For Research Use only |
HandlingProduct Details anti-FZD7 Antibody Target Details FZD7 Application Details References for anti-FZD7 antibody (ABIN2776708) Images back to top |
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Format | Liquid |
Concentration | Lot specific |
Buffer | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose. |
Preservative | Sodium azide |
Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handling Advice | Avoid repeated freeze-thaw cycles. |
Storage | -20 °C |
Storage Comment | For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
References for anti-FZD7 antibody (ABIN2776708)Product Details anti-FZD7 Antibody Target Details FZD7 Application Details Handling Images back to top |
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Product cited in: |
McIver, Stanger, Santarelli, Roman, Nixon, McLaughlin: "A unique combination of male germ cell miRNAs coordinates gonocyte differentiation." in: PLoS ONE, Vol. 7, Issue 4, pp. e35553, 2012 Schmuck, Warneke, Behrens, Simon, Weichert, Röcken: "Genotypic and phenotypic characterization of side population of gastric cancer cell lines." in: The American journal of pathology, Vol. 178, Issue 4, pp. 1792-804, 2011 Gökmen-Polar, Toroni, Hocevar, Badve, Zhao, Shen, Bruckheimer, Kinch, Miller: "Dual targeting of EphA2 and ER restores tamoxifen sensitivity in ER/EphA2-positive breast cancer." in: Breast cancer research and treatment, Vol. 127, Issue 2, pp. 375-84, 2011 Ohba, Lanigan, Roessler: "Leptin receptor JAK2/STAT3 signaling modulates expression of Frizzled receptors in articular chondrocytes." in: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, Vol. 18, Issue 12, pp. 1620-9, 2010 Ueno, Hiura, Suehiro, Hazama, Hirata, Oka, Imai, Dahiya, Hinoda: "Frizzled-7 as a potential therapeutic target in colorectal cancer." in: Neoplasia (New York, N.Y.), Vol. 10, Issue 7, pp. 697-705, 2008 |
Background publications |
Vincan, Darcy, Smyth, Thompson, Thomas, Phillips, Ramsay: "Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth." in: Differentiation; research in biological diversity, Vol. 73, Issue 4, pp. 142-53, 2005 |
ImagesProduct Details anti-FZD7 Antibody Target Details FZD7 Application Details Handling References for anti-FZD7 antibody (ABIN2776708) back to top |
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Supplier Images |