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Structure of the dual-mode Wnt (show WNT2 Proteins) regulator Kremen1 and insight into ternary complex formation with LRP6 (show LRP6 Proteins) and DKK1 (show DKK1 Proteins) have been presented.
Ectodermal dysplasia including oligodontia is due to homozygosity for KREMEN1 p.F209S (c.626 T>C).
Kremen1 has a pro-apoptotic activity that is decreased upon Dkk1 (show DKK1 Proteins) binding or by cancer mutations.
Six Dkk-1 (show DKK1 Proteins), three Sost (show SOST Proteins), one Kremen-1 and 10 LRP-5 (show LRP5 Proteins) polymorphisms were significantly associated with radiological progression of rheumatoid arthritis joint destruction.
The mRNA expression levels of DKK-1 (show DKK1 Proteins) binding receptor LRP5 (show LRP5 Proteins)/6 and Krm1/2 in SCs (show TWIST1 Proteins) from patients with MM were significantly higher than those in myeloma cells and in SCs (show TWIST1 Proteins) from healthy donors.
This study demonstrated that a representative tSNP of KREMEN1 might modulate the risk of schizophrenia in the Japanese population.
Kremen may not be essential for Dkk1 (show DKK1 Proteins)-mediated Wnt (show WNT2 Proteins) antagonism and Kremen may only play a role when cells express a high level of LRP5 (show LRP5 Proteins)/6
Functional characterization (show DKK1 Proteins)of related Kremen proteins i (show WNT2 Proteins)n mouse.
Kremen1 has a pro-apoptotic activity that is decreased upon Dkk1 (show DKK1 Proteins) binding
Kremen proteins are Dickkopf (show DKK1 Proteins) receptors that regulate Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signalling
Dkk1 (show DKK1 Proteins) and Kremen1 play roles in blastocyst activation and uterine receptivity during the window of implantation.
This study provides the first genetic evidence for a functional interaction of Kremen proteins with Dkk1 (show DKK1 Proteins) as negative regulators of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
Kremen1 modulates Wnt (show WNT2 Proteins) activity by restricting the range of secreted Dkk (show DKK1 Proteins) proteins during collective cell migration in the posterior lateral line primordium
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
kringle containing transmembrane protein 1
, kringle-containing transmembrane protein 1
, kremen 1
, kremen protein 1-like
, dickkopf receptor
, kremen protein 1
, kringle domain-containing transmembrane protein 1
, kringle-coding gene marking the eye and the nose
, kringle-containing protein marking the eye and the nose