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Human LEF1 Protein expressed in Wheat germ - ABIN1309292
Shimomura, Takasaki, Nomura, Hayashi, Senda: Identification of DNA-dependent protein kinase catalytic subunit as a novel interaction partner of lymphocyte enhancer factor 1. in Medical molecular morphology 2013
Data suggest that LEF1-dependent genes in zebrafish hypothalamus are associated with anxiety; LEF1 null mutant zebrafish exhibit increased anxiety.
mesodermal Wnt3a (show WNT3A Proteins)-mediated signaling via the transcription factor Lef1 positively regulates EC specification (defined by kdrl expression) at the expense of primitive erythrocyte specification (defined by gata1 (show GATA1 Proteins) expression) in zebrafish embryos.
Amotl2a (show AMOTL2 Proteins) function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 (show YAP1 Proteins) and the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) effector Lef1.
Lef1 has a role in regulating Dusp6 (show DUSP6 Proteins) in formation of the zebrafish posterior lateral line primordium
Nlk2 (show NLK Proteins) is essential for the phosphorylation and activation of Lef1 transcriptional activity in neural progenitor cells.
Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium.
Lef1 sustains proliferation of leading zone progenitors, maintaining the primordium size and defining neuromast deposition rate.
Data conclude that lef1-mediated Wnt (show WNT2 Proteins) signaling is involved in various aspects of primordium migration, although part of this implication is masked by a high level of developmental redundancy.
Data show cooperation between Dnmt3 and an H3K9 methyltransferase G9a (show EHMT2 Proteins) in regulating lef1.
high-affinity binding sites for Tcf (show HNF4A Proteins)/Lef1 within the boz promoter region
Lef1 and Tcf1 (show HNF1A Proteins) showed oncogenic effect in colonic carcinogenesis. Cellular context of miRNAs might play important roles in carcinogenesis by altering the expression pattern of Lef/Tcfs members.
Data (including data from studies using transgenic/knockout mice) suggest that expression of Lef1 in hypothalamus inhibits anxiety and regulates neurogenesis; expression of Lef1 in hypothalamus is required for neurogenesis.
Uncovering a Pitx2 (show PITX2 Proteins)-Sox2 (show SOX2 Proteins)-Lef-1 transcriptional mechanism that regulates dental epithelial stem cells homeostasis and dental development.
this study shows that the transcription factors Tcf1 (show HNF1A Proteins) and Lef1 suppress CD4 (show CD4 Proteins)+ T lineage genes in CD8 (show CD8A Proteins)+ T cells through intrinsic histone deacetylase (show HDAC1 Proteins) activity
leukemic stem cells are therefore more sensitive to loss of Tcf1 (show HNF1A Proteins) and Lef1 than Hematopoietic Stem Cells in their self-renewal capacity.
Sp5 (show SP5 Proteins)/8 bind directly to GC boxes in Wnt (show WNT2 Proteins) target gene enhancers and to adjacent, or distally positioned, chromatin-bound T-cell factor (Tcf) 1 (show HNF1A Proteins)/lymphoid enhancer factor (Lef) 1 to facilitate recruitment of beta-catenin (show CTNNB1 Proteins) to target gene enhancers.
This paper demonstrates a cell-intrinsic requirement for transcription factors TCF1 (show HNF1A Proteins) and LEF1 for the development of all subsets of Natural Killer T cells.
this study gives new insights into transcriptional regulating mechanisms of Wnt (show WNT2 Proteins)-mediated Isl1 (show ISL1 Proteins) expression during cardiomyocyte differentiation.
data reveal LEF1 as a central regulator of iNKT cell number and Th2-type effector differentiation.
These findings provide evidence for the existance of a posititve feedback loop connecting survivin expression in tumor cells to PI3K/Akt enhanced beta-catenin-Tcf/Lef-dependent transcription followed by secretion of VEGF and angiogenesis.
Tcf (show HNF4A Proteins)/Lef genes encode factors of different activities, which function together in antagonistic or synergistic ways to modulate the intensity and outcome of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signalling and to trigger tissue-specific responses.
Interaction of Xom and LEF1/TCF (show HNF4A Proteins)-factors is essential for ventral cell fate determination and LEF1/TCF (show HNF4A Proteins) factors may function as a point of convergence to mediate the combined signaling of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) and BMP4 (show BMP4 Proteins)/Xom pathways during early embryogenesis.
Positive LEF-1 favors a benign neoplasm.
Results show that high enhancer-binding factor-1 (LEF1) expression is associated with poor survival for chronic lymphocytic leukemia (CLL) patients.
Knockdown of GATA6 (show GATA6 Proteins) completely eliminated the effect of TCF1 (show HNF1A Proteins), while forced expression of GATA6 (show GATA6 Proteins) induced hESC differentiation
Data indicate that microRNA miR (show MLXIP Proteins)-27a directly targets GSK-3beta and increases expression of beta-catenin (show CTNNB1 Proteins) and LEF1 in all-trans-retinoic acid (ATRA)-induced Hep2 cells.
and CTU1 (show CTU1 Proteins)/2, partner enzymes in U34 methoxycarbonylmethyl-2-thio (show ACAA1 Proteins) tRNA modification, are up-regulated in human breast cancers and sustain metastasis.
EVI1 (show MECOM Proteins) transcription is directly regulated by LEF1/beta-catenin (show CTNNB1 Proteins) complex in myeloid blast crisis of chronic myeloid leukemia (show BCL11A Proteins). Loss of p53 (show TP53 Proteins) function as a key regulator for beta-catenin (show CTNNB1 Proteins)-EVI1 (show MECOM Proteins) in myeloid blast crisis of chronic myeloid leukemia (show BCL11A Proteins).
LEF1 is a sensitive and specific marker for chronic lymphocytic B-cell leukemia
a frequency of 4-9% expression of LEF1 bymantle cell lymphoma
The results suggest a role for beta-catenin (show CTNNB1 Proteins)/LEF1-mediated transcription in both malignant transformation and metastasis of prostate cancer
The molecular characterisation of the porcine LEF1 gene and its association with number of teats and inverted teats in experimental and commercial populations, is described.
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.
lymphoid enhancer binding factor-1
, lymphoid enhancer-binding factor 1
, lymphoid enhancer-binding factor 1-like
, lymphoid enhancer binding factor 1 short isoform
, T cell-specific transcription factor 1-alpha
, lymphiod enhancer binding factor 1
, transcription factor LEF-1
, lymphoid enhancer binding factor 1