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|Antigen||Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) Antibodies|
|Conjugate||This LRP6 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-LRP6 AntibodyTarget Details LRP6 Application Details Handling Images
|Specificity||This antibody reacts to LRP6.|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human LRP6.|
Target Details LRP6Product Details anti-LRP6 Antibody Application Details Handling Images back to top
|Alternative Name||LRP6 (LRP6 Antibody Abstract)|
|Background||LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.Synonyms: LRP-6, Low-density lipoprotein receptor-related protein 6|
|Gene ID||4040, 9606|
|Research Area||Stem Cells, Wnt, Wnt Signaling|
|Pathways||WNT Signaling, Tube Formation|
Application DetailsProduct Details anti-LRP6 Antibody Target Details LRP6 Handling Images back to top
ELISA: 1/1,000. Western blot: 1/100 - 1/500. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-LRP6 Antibody Target Details LRP6 Application Details Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|