We are preparing the requested document. Please wait, this may take a while...!
|Antigen||Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) Antibodies|
|Epitope||AA 1470-1520, pSer1490 Alternatives|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This LRP6 antibody is un-conjugated Alternatives|
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
|2 references available|
|Supplier||Log in to see|
Product Details anti-LRP6 AntibodyTarget Details LRP6 Application Details Handling References for anti-LRP6 antibody (ABIN743558) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic phosphopeptide derived from human LRP6 around the phosphorylation site of Ser1490|
Target Details LRP6Product Details anti-LRP6 Antibody Application Details Handling References for anti-LRP6 antibody (ABIN743558) Images back to top
|Alternative Name||Lrp6 (LRP6 Antibody Abstract)|
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
Subcellular location: Cytoplasm
Synonyms: ADCAD2, Low-density lipoprotein receptor-related protein 6, LRP-6, LRP6
|Pathways||WNT Signaling, Tube Formation|
Application DetailsProduct Details anti-LRP6 Antibody Target Details LRP6 Handling References for anti-LRP6 antibody (ABIN743558) Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-LRP6 Antibody Target Details LRP6 Application Details References for anti-LRP6 antibody (ABIN743558) Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-LRP6 antibody (ABIN743558)Product Details anti-LRP6 Antibody Target Details LRP6 Application Details Handling Images back to top
|Product cited in:||
Boone, Arend, Johnston, Cooper, Gilchrist, Oelschlager, Grizzle, McGwin, Gangrade, Straughn, Buchsbaum: "Targeting the Wnt/β-catenin pathway in primary ovarian cancer with the porcupine inhibitor WNT974." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 96, Issue 2, pp. 249-59, 2016 Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Human).
Chen, Xu, Ye, Li, Gong, Zhang, Wu, Jia, Liu, Chen, Yang, Tang, Zhu, Ge, Zou: "Urotensin II inhibited the proliferation of cardiac side population cells in mice during pressure overload by JNK-LRP6 signalling." in: Journal of cellular and molecular medicine, Vol. 18, Issue 5, pp. 852-62, 2014 (Sample species: Mouse (Murine)).
ImagesProduct Details anti-LRP6 Antibody Target Details LRP6 Application Details Handling References for anti-LRP6 antibody (ABIN743558) back to top