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Human TCF7L2 Protein expressed in Wheat germ - ABIN1322376
Shitashige, Satow, Honda, Ono, Hirohashi, Yamada: Regulation of Wnt signaling by the nuclear pore complex. in Gastroenterology 2008
Suggest transcription factor 7-like 2 is a possible regulator of glucagon-like peptide 1 receptor (show GLP1R Proteins) expression in endothelial/smooth muscle cells in diabetic mice.
along with the elevation of miR-17-5p expression in mouse epididymal fat tissue in response to high fat diet consumption, allowed us to suggest that miR-17-5p is among central switches of adipogenic differentiation
TCF7L2 mediates canonic Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling and c-Myc (show MYC Proteins) upregulation during abnormal cardiac remodeling in heart failure and suppression of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) to c-Myc (show MYC Proteins) axis can be explored for preventing and treating heart failure.
These findings suggest a unique role for Tcf7l2 in generating distinct neuronal phenotypes from homogeneous progenitor population.
Tcf7l2 may be involved in maintenance of stem/progenitor cells properties.
results indicate that miR (show MLXIP Proteins)-181a-5p promotes 3T3-L1 preadipocyte differentiation and adipogenesis through regulating TGFbeta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) and Wnt (show WNT2 Proteins) signaling pathway by directly targeting Smad7 (show SMAD7 Proteins) and Tcf7l2
Tcf7l2 protein levels decline upon initiation of endocrine differentiation in vivo, disclosing the downregulation of this factor in the developing endocrine compartment.
Kaiso (show ZBTB33 Proteins) and Sox10 (show SOX10 Proteins) sequentially interact with Tcf7l2 to coordinate the maturation of oligodendrocyte.
Tcf7l2 plays a cell autonomous role in the control of beta cell function and mass, serving as an important regulator of gene expression and islet cell coordination
Tcf7l2 is regulating proinsulin (show INS Proteins) expression directly via Isl1 (show ISL1 Proteins), Ins1 and indirectly via MafA (show MAFA Proteins), NeuroD1 (show NEUROD1 Proteins) and Pdx1 (show PDX1 Proteins).
Tcf7l2 is essential for lateralized fate selection by habenular neurons that can differentiate along two alternative pathways, thereby leading to major neural circuit asymmetries.
Dorsal and ventral habenulae develop in different regions of prosomere 2. In the process of ventral habenula formation, functional tcf7l2 gene activity is required and in its absence, ventral habenular neurons do not develop.
In embryos, the tcf4 gene is highly regulated at the level of RNA splicing such that the variant proteins that are produced contain or lack domains proposed to be essential in repression or activation of transcription.
Study underscores the involvement of Tcf4 in maintaining proliferative self-renewal in the intestine throughout life.
This study reveals that Tcf4 (tcf7l2) is the major effector of Wnt (show WNT2 Proteins) signaling in the intestine during zebrafish organogenesis.
XTcf4 has no repressive role but is required to activate expression of Xnr3 and chordin (show CHRD Proteins) in organizer cells at the gastrula stage
regulation of XTcf-4 by canonical wnt (show WNT2 Proteins)-signaling is directly controlled by binding to and activating a consensus Lef/Tcf (show HNF4A Proteins) binding site within its own promoter
These findings further support the hypothesis that TCF7L2 gene variation contributes to diabetogenesis in a subset of young people with Type 1 diabetes.
The rs7903146 variant in the TCF7L2 gene increases the risk of impaired glucose tolerance or type 2 diabetes in obese adolescents by impairing beta-cell function, and hepatic insulin (show INS Proteins) sensitivity predicts the development of impaired glucose tolerance or type 2 diabetes over time.
In conclusion, TCF7L2 regulates estradiol- or progesterone-modulated islet and hepatic glucose metabolism.
TCF7L2 rs7903146 and 112/112 haplotype of CAPN10 (show CAPN10 Proteins) might be associated with gestational diabetes risks.[meta-analysis]
Authors found that KIF23 was regulated by TCF-4 at transcriptionally level. Therefore, this evidence indicates KIF23 over-expression is associated with glioma malignancy and conferred a worse survival time in glioma.
findings indicate that the association between TCF7L2 SNP rs12255372 and HDL (show HSD11B1 Proteins)-C may be modified by dietary fat intake in this Asian Indian population
Wnt (show WNT2 Proteins) Signaling Pathway Effector TCF7L2 plays a role in Glucose Homeostasis.
The variant in TCF7L2 that increases fasting glucose levels increases between-subject variance, whereas variants in GCK and G6PC2 that increase fasting glucose levels decrease between-subject variance.
The rs7903146 (C/T) polymorphism of the TCF7L2 gene might not be associated with obesity in the Cameroonian population.
These findings suggest that the rs7903146 locus might exert its enhancer function by interacting with HMGB1 (show HMGB1 Proteins) in an allele dependent manner.
findings report an independent confirmation of the association of the TCF7L2 (show TCF4 Proteins) gene with milk yield and composition traits.
Genes implied in human type 2 diabetes development, TCF7L2, WFS1 (show WFS1 Proteins), FTO (show FTO Proteins), SLC30A8 (show SLC30A8 Proteins), and GCKR (show GCKR Proteins), were mapped on Sus scrofa chromosomes 14, 8, 6, 4, and 3, respectively. Only TCF7L2 was significantly associated with five fat traits in pigs.
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.
transcription factor 7-like 2 (T-cell specific, HMG-box)
, HMG box transcription factor 4
, T-cell factor 4
, T-cell-specific transcription factor 4
, transcription factor 7-like 2
, transcription factor 7-like 2, T-cell specific, HMG-box
, transcription factor tcf4
, T-cell factor XTCF-4A
, transcription factor Tcf4
, T-cell factor-4 variant A
, T-cell factor-4 variant B
, T-cell factor-4 variant C
, T-cell factor-4 variant D
, T-cell factor-4 variant E
, T-cell factor-4 variant F
, T-cell factor-4 variant G
, T-cell factor-4 variant H
, T-cell factor-4 variant I
, T-cell factor-4 variant J
, T-cell factor-4 variant K
, T-cell factor-4 variant L
, T-cell factor-4 variant M
, T-cell factor-4 variant X2