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anti-Mouse (Murine) WNT4 Antibodies:
anti-Human WNT4 Antibodies:
anti-Rat (Rattus) WNT4 Antibodies:
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Human Polyclonal WNT4 Primary Antibody for IF (p), IHC (p) - ABIN762911
Hua, Xu, He, Jiang, Ye, Pan: Wnt4/?-catenin signaling pathway modulates balloon-injured carotid artery restenosis via disheveled-1. in International journal of clinical and experimental pathology 2015
Show all 3 Pubmed References
Human Polyclonal WNT4 Primary Antibody for ELISA, WB - ABIN249475
Huguet, McMahon, McMahon, Bicknell, Harris: Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. in Cancer research 1994
Human Polyclonal WNT4 Primary Antibody for IHC (p), WB - ABIN390635
Kuulasmaa, Jääskeläinen, Suppola, Pietiläinen, Heikkilä, Aaltomaa, Kosma, Voutilainen: WNT-4 mRNA expression in human adrenocortical tumors and cultured adrenal cells. in Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2008
Show all 2 Pubmed References
Human Polyclonal WNT4 Primary Antibody for FACS, IHC (p) - ABIN652224
Fang, Zeng, Wang, Liu, Xu, Dai, Zhao, Zhang, Liang, Chen, Shi, Zhang, Wang, Qiao, Shi: Estimated diversity of messenger RNAs in each murine spermatozoa and their potential function during early zygotic development. in Biology of reproduction 2014
Show all 2 Pubmed References
Human Polyclonal WNT4 Primary Antibody for IHC, IHC (p) - ABIN4366182
Lin, Jan, Kuo: Exploring MicroRNA Expression Profiles Related to the mTOR Signaling Pathway in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine. in Molecular pharmaceutics 2015
At different points of development, dWnt4 switches from using the non-canonical pathway components to using a beta (show SUCLA2 Antibodies)-catenin-dependent canonical pathway in the escort cells to facilitate the proper differentiation of Germline stem cells.
disruption of Wnt4 and components of the canonical Wnt pathway results in a complex germ cell phenotype marked by an expansion of germline stem cell-like cells, pre-cystoblasts and cystoblasts in young females.
Wnt4 and the canonical Wnt signaling pathway are essential for ostia formation in Drosophila
dSETDB1 is required for the expression of a Wnt ligand, Drosophila Wingless type mouse mammary virus integration site number 4 (dWnt4) in the somatic niche.
this study identifies a transcriptional switch involving the kinase Btk29A/Btk and its phosphorylation target, beta-catenin, which functions downstream of Wnt4 in escort cells to terminate Drosophila germ cell proliferation through up-regulation of piwi expression.
Wg and Wnt4 act redundantly in planar cell polarity determination in Drosophila.
We re-evaluated the expression pattern of DWnt4 during embryogenesis and show that transcripts are not restricted to the dorsal ectoderm but are also present in the cardiogenic mesoderm.
In Drosophila, Otk interacts with Wnt4 and opposes canonical Wnt signalling in embryonic patterning.
DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis.
DWnt4 antagonizes the polarizing effect of four-jointed
urinary Wnt4 could be a potential noninvasive biomarker for the early detection of tubular injury.
SHH (show SHH Antibodies)-dependent activation of WNT (show WNT2 Antibodies) signaling supports regeneration of the cortex following long-term glucocorticoid treatment.
Wnt4 and Wnt11 (show WNT11 Antibodies) cooperatively contribute to mammalian neuromuscular junction formation.
GLP-1 (show GCG Antibodies) promoted adipogenesis through the modulation of the Wnt4/beta-catenin (show CTNNB1 Antibodies) signaling pathway
Results suggest that the Wnt4 gene encodes signals that are important for various aspects of female reproductive tract development.
Our functional study revealed that WNT4 molecules were involved in regulating zygotic cleavage and early embryogenesis
Data indicate that a balance between supporting cell (show PTPRJ Antibodies) self-renewal and differentiation is maintained in the developing ovary by relative Wnt4 protein/beta-catenin (show CTNNB1 Antibodies) and p27Kip1 (show CDKN1B Antibodies) protein (p27 (show CDKN1B Antibodies))/Forkhead box L2 (FOXL2 (show FOXL2 Antibodies)) activities.
decreased expression of Wnt4 in the aging thymus may be one of the molecular triggers underlying the process of age-related thymic senescence.
Mir (show MLXIP Antibodies)-29c regulates WNT4 signaling.
Wnt4 is essential to normal mammalian lung development.
We found a genetic association between rs11031006 (FSHB (show FSHB Antibodies)) SNP and endometriosis. WNT4 and VEZT (show VEZT Antibodies) genes constitute the most consistently associated genes with endometriosis. In the present study, an association of rs7521902 (WNT4) and rs10859871 (VEZT (show VEZT Antibodies)) was confirmed in women with endometriosis at the genotypic but not the allelic level.
were not able to replicate or further verify the genetic association of polymorphisms in WNT4 and WNT5B (show WNT5B Antibodies) with bone mineral density
These findings demonstrate that autocrine human growth hormone (show GH1 Antibodies) regulates WNT4 expression and that WNT4 is a potential therapeutic target in human breast cancer.
WNT4 encodes wingless-type MMTV integration site family member 4. WNT4 mutations have been found in women with mullerian duct abnormalities, primary amenorrhea, and hyperandrogenism and common variants in WNT4, which are in high linkage disequilibrium with our index SNPs, are associated with endometriosis, ovarian cancer,and bone mineral density of WNT4, and the T allele generates a strong ESR1 (show ESR1 Antibodies)-binding site.
Our MRKH families included 43 quads, 26 trios, and 30 duos. Of our MRKH probands, 87/147 (59%) had MRKH type 1 and 60/147 (41%) had type 2 with additional anomalies. CONCLUSION(S): Although the prevalence of WNT4, HNF1B (show HNF1B Antibodies), and LHX1 (show LHX1 Antibodies) point mutations is low in people with MRKH, the prevalence of CNVs was approximately 19%.
WNT4 drives a novel signaling pathway in ILC (show CCL27 Antibodies) cells, with a critical role in estrogen-induced growth that may also mediate endocrine resistance. WNT4 signaling may represent a novel target to modulate endocrine response specifically for patients with ILC (show CCL27 Antibodies).
The etiology of MRKH syndrome is still largely unknown, probably because of its intrinsic heterogeneity. Several candidate causative genes have been investigated, but to date only WNT4 has been associated with MRKH with hyperandrogenism. This review summarizes and discusses the clinical features and details progress to date in understanding the genetics of MRKH syndrome.
We highlight the cooperation of WNT4, RSPO1 (show RSPO1 Antibodies) and FOXL2 (show FOXL2 Antibodies) within a regulatory network and the need for further research to better understand their role in defining and maintaining ovarian identity.
The WNT4 expression level in eutopic endometrium was significantly reduced compared with that in normal endometrium of the control group.
identified Wnt4 as the ligand that is expressed in the mesoderm of the ventral blood island and is essential for the expression of hematopoietic and erythroid marker genes
XWntless and the Retromer complex are required for the efficient secretion of XWnt4, facilitating its role in Xenopus eye development
Study shows that Wnt-4 acts through the Notch (show NOTCH1 Antibodies) effector gene hrt1 (show HEY1 Antibodies) by upregulating expression of wnt4; Wnt-4 then patterns the proximal pronephric anlagen to establish the specific compartments that span the medio-lateral axis.
single inhibition of melatonin receptor 1 or Wnt-4 expression decreased expression of neurogenesis-related genes, and bovine amniotic epithelial cell-derived neural cells were successfully colonized into injured spinal cord, which suggested participation in tissue repair.
Fox1 (show A2BP1 Antibodies) activation of Wnt4a in the ectoderm signals the epithelial stabilization of pouch-forming cells during late-stage of pouch morphogenesis.
Data show that in vivo, wnt11r (show WNT11 Antibodies) and wnt4a initiate MuSK (show MUSK Antibodies) translocation from muscle membranes to recycling endosomes and that this transition is crucial for AChR accumulation at future synaptic sites.
Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt (show WNT2 Antibodies) signaling inhibitor, Dkk (show DKK1 Antibodies), and induced expression of the Wnt (show WNT2 Antibodies) ligand, Wnt4a.
Findings provide the first convincing line of evidence that EAF and Wnt4 form an auto-regulatory negative feedback loop in vivo.
three Wnt (show WNT2 Antibodies) noncanonical ligands wnt4a, silberblick/wnt11 (show WNT11 Antibodies), and wnt11 (show WNT11 Antibodies)-related regulate the process of convergence of endoderm and organ precursors toward the embryonic midline by acting in a largely redundant way
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.
, wingless-type MMTV integration site family, member 4
, protein Wnt-4
, signal molecule
, wingless-related MMTV integration site 4
, Wnt-4 protein
, protein Wnt-4a