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anti-Mouse (Murine) WNT8A Antibodies:
anti-Human WNT8A Antibodies:
anti-Rat (Rattus) WNT8A Antibodies:
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Caudal (show CAD Antibodies) Wnt8a is expressed only early somite stages. It is needed for normal anterior trunk development in the absence of Wnt3a (show WNT3A Antibodies). Wnt8a and Wnt3a (show WNT3A Antibodies) cooperate to maintain Fgf8 (show FGF8 Antibodies) expression and stop premature Sox2 (show SOX2 Antibodies) up-regulation in the axial stem cell niche.
Wnt8a expression depends on the presence of Fgf3 (show FGF3 Antibodies) indicating a serial regulation between Fgf and Wnt (show WNT2 Antibodies) signalling during otic placode induction and specification.
demonstrate that both the enlargement of the otic placode and the expansion of the Wnt8a expression domain can be rescued in Spry1 (show SPRY1 Antibodies)/; Spry2 (show SPRY2 Antibodies)/ embryos by reducing the gene dosage of Fgf10 (show FGF10 Antibodies)
FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a.
The Wnt8A expression was evaluted in the resultant Tg(CAG-mWnt8A) embryos to identify mWnt8A misexpression.
the WNT8A gene is involved in the susceptibility to HSCR (show EDNRB Antibodies), and plays an important role in the occurrence and development of Hirschsprung's disease.
Expression and regulation of WNT8A mRNA in human tumor cell lines
Data suggest that Wnt3 (show WNT3A Antibodies), Wnt3a (show WNT3A Antibodies), and Wnt8a bind to their respective receptors (Fz8 (show FZD2 Antibodies), Lrp6 (show LRP5 Antibodies), and Lypd6 (show LYPD6 Antibodies)) in ordered plasma membrane environments; ordered plasma membrane environments appear to be essential for binding of Wnt (show WNT2 Antibodies) proteins to their receptor complexes and stimulation of downstream signaling activity.
Wnt8, in addition to its well-established role in posterior mesoderm patterning, also plays a later role as a factor that expands the renal progenitor pool prior to kidney morphogenesis.
Cortical depth and differential transport of vegetally localized dorsal and germ line determinants, Wnt8a, grip2a, and Dazl (show DAZL Antibodies), in the zebrafish embryo have been presented.
Gain of function of Wnt8a results in the accumulation of beta-catenin (show CTNNB1 Antibodies) into the nuclei of all cells of the gastrula from the margin to the animal pole.
A filopodia-based transport system for Wnt8a controls anteroposterior patterning of the neural plate during vertebrate gastrulation.
Wnt (show WNT2 Antibodies) limits its own signaling activity in part via up-regulation of a transporter, slc35c1 (show SLC35C1 Antibodies) that promotes terminal fucosylation and thereby limits Wnt (show WNT2 Antibodies) activity.
Dynamic association with donor cell filopodia and lipid-modification are essential features of Wnt8a during patterning of the zebrafish neuroectoderm.
post-transcriptional control of wnt8a is essential to fine tune the balance of the signaling outputs of the complex wnt8a locus, which is essential to zebrafish axis development
A novel role for Eaf1 (show EAF1 Antibodies) and Eaf2 (show EAF2 Antibodies) in inhibiting canonical Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling, which might form the mechanistic basis for Eaf1 (show EAF1 Antibodies) and Eaf2 (show EAF2 Antibodies) tumor suppressor activity.
Wnt8a expression pattern reflects complex interactions of multiple regulatory inputs.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. It encodes a protein which shows 81% amino acid identity to the mouse Wnt8A protein.
wingless-type MMTV integration site family, member 8A
, protein Wnt-8a
, protein Wnt-8a-like
, protein Wnt-8d
, stimulated by retinoic acid gene 11 protein
, wingless-related MMTV integration site 8D
, wingless-related MMTV integration site 8A
, protein Wnt-8a ORF1
, protein Wnt-8c