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7-Dehydrocholesterol Reductase Proteins (DHCR7)

DHCR7 encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. Additionally we are shipping DHCR7 Antibodies (40) and DHCR7 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DHCR7 13360 O88455
Rat DHCR7 DHCR7 64191 Q9Z2Z8
DHCR7 1717 Q9UBM7
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Top DHCR7 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days

DHCR7 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

More Proteins for 7-Dehydrocholesterol Reductase (DHCR7) Interaction Partners

Xenopus laevis 7-Dehydrocholesterol Reductase (DHCR7) interaction partners

  1. Results suggest that 7-dehydrocholesterol reductase and Sonic Hedgehog (show SHH Proteins) are co-expressed during midline development in Xenopus embryos.

  2. Data from Xdhcr7 overexpression and knockdown experiments reveals that a tight control of cholesterol synthesis is particularly important for proper development of the central and peripheral nervous system

Arabidopsis thaliana 7-Dehydrocholesterol Reductase (DHCR7) interaction partners

  1. both Delta(5,7)-sterol-Delta(7)-reductase and Delta(24)-sterol-Delta(24)-reductase are in addition localized to the plasma membrane, whereas Delta(7)-sterol-C(5)-desaturase was clearly detected in lipid particles

Mouse (Murine) 7-Dehydrocholesterol Reductase (DHCR7) interaction partners

  1. Studied the effect of 7-dehydrocholesterol reductase (Dhcr7) and identified signal pathways involved in regulation of embryonic palatogenesis. Expression changes of Dhcr7, Sonic Hedgehog (Shh (show SHH Proteins)), and bone morphogenetic protein-2 (Bmp2 (show BMP2 Proteins)) were measured by RT-PCR and WB after Dhcr7 gene silencing and the addition of exogenous cholesterol.

  2. significant increases in Col1a1 (show COL1A1 Proteins), serine/threonine-protein kinase 1, Ctnnb1 (show CTNNB1 Proteins), CSRNP1 (show CSRNP1 Proteins), Ddit4 (show DDIT4 Proteins), Cyp2e1 (show CYP2E1 Proteins), and Krit1 (show KRIT1 Proteins) expressions and great decreases inreceptor D2, Neu1 (show NEURL Proteins), and Dhcr7 expressions following long-term exposure to TiO2 NPs (show NPS Proteins)

  3. data indicate an underlying dysfunction of the 5-HT2A receptors in Dhcr7-HET mice that warrants further investigation to establish how this may relate to behavioral disturbances in human patients carrying Dhcr7 mutations

  4. conclude that cytochrome P450 reductase (show POR Proteins) is not involved in 7-dehydrocholesterol reductase activity

  5. Data suggest that although cholesterol synthesis is impaired in both Dhcr7 mutant and Sc5d (show SC5DL Proteins)(-/-) embryonic brain, synthesis of nonsterol isoprenoids may be increased and thus contribute to Smith-Lemli-Opitz syndrome and lathosterolosis pathology.

  6. Immunohistochemical analyses have revealed a 306% increase in the area of 5-HT (show DDC Proteins) immunoreactivity (5-HT (show DDC Proteins) IR) in the hindbrains of mutant (Dhcr7-/-) mice as compared to age-matched wild type animals.

  7. Of the 12,000 genes analyzed, 91 were upregulated and 98 were downregulated in the Dhcr7-/- hindbrains when compared to wild-type animals.

  8. CNS defects caused by Dhcr7 null likely play a major role in the lethal pathogenesis of Dhcr7-/- mice, with the peripheral organs contributing the morbidity

  9. Data show that in vitro down regulation of NRIF expression decreased the mRNA for two main cholesterogenic enzymes, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (show HMGCR Proteins) and 7-dehydrocholesterol reductase.

  10. down-regulation of Dhcr7 altered expression of multiple molecules that play critical roles in intracellular signaling or vesicular transport or are inserted into membrane rafts, and down-regulated several critical genes involved in lipid biosynthesis

Human 7-Dehydrocholesterol Reductase (DHCR7) interaction partners

  1. In this study, we demonstrate that the prevalent c.964-1G>C Dhcr7 mutation perturbs SMO cilia localization and SHH (show SHH Proteins) pathway activation as a consequence of reduced cholesterol biosynthesis

  2. these findings highlight DHCR7 as an important regulatory switch between cholesterol and vitamin D synthesis.

  3. The aim of this study was to investigate the association of three polymorphisms in the GC gene (rs7041 and rs4588) and CYP2R1 (show CYP2R1 Proteins) gene (rs10741657) on 25-(OH) VD serum concentration among Jordanians.

  4. This study shows that Smith-Lemli-Opitz Syndrome patients who are heterozygous/homozygous for one pathogenic mutation and only one parent carrying that mutation are candidates for DHCR7 gene (partial) deletions.

  5. Polymorphisms in CYP2R1 (show CYP2R1 Proteins)-rs10766197 and DHCR7/NADSYN1 (show NADSYN1 Proteins)-rs12785878 are associated with vitamin D deficiency in Uygur and Kazak ethnic populations

  6. physical and functional interaction between DHCR24 (show DHCR24 Proteins) and DHCR7

  7. In this mendelian randomisation study, we generated an allele score (25[OH]D synthesis score) based on variants of genes that affect 25(OH)D synthesis or substrate availability (CYP2R1 (show CYP2R1 Proteins) and DHCR7)

  8. rs3829251 (DHCR7) influenced progression of subclinical atherosclerosis in a manner dependent on type 2 diabetes status but independent of 25(OH)D levels. The SNP modulates DHCR7 mRNA levels in aortic adventitia.

  9. NADSYN1 (show NADSYN1 Proteins)/DHCR7 locus (rs12785878 and rs1790349) polymorphisms have an effect on plasma 25-hydroxyvitamin D levels and coronary artery disease incidence

  10. This study provides evidence that the DHCR7 gene is involved in the susceptibility to ocular Behcet disease.

DHCR7 Protein Profile

Protein Summary

This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS)\; a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.

Gene names and symbols associated with DHCR7

  • 7-dehydrocholesterol reductase (DHCR7)
  • 7-dehydrocholesterol reductase (dhcr7)
  • 7-dehydrocholesterol reductase (DWF5)
  • 7-dehydrocholesterol reductase (PAAG_04766)
  • 7-dehydrocholesterol reductase (PITG_13128)
  • 7-dehydrocholesterol reductase (VDBG_05423)
  • 7-dehydrocholesterol reductase (MGYG_00712)
  • 7-dehydrocholesterol reductase (TERG_00580)
  • 7-dehydrocholesterol reductase (Dhcr7)
  • 7-Dhcr protein
  • 7RED protein
  • AA409147 protein
  • DELTA5 protein
  • DKFZp468C1911 protein
  • DWARF 5 protein
  • F11F12.21 protein
  • F11F12_21 protein
  • LE protein
  • LEPIDA protein
  • MGC64361 protein
  • PA protein
  • PARVA protein
  • SLOS protein
  • ST7R protein
  • xdhcr7 protein

Protein level used designations for DHCR7

7-DHC reductase , sterol Delta(7)-reductase , 7-dehydrocholesterol reductase , delta-7-dehydrocholesterol reductase , putative sterol reductase SR-2 , sterol delta-7-reductase

100061433 Equus caballus
378446 Danio rerio
380248 Xenopus laevis
394844 Xenopus (Silurana) tropicalis
841465 Arabidopsis thaliana
9096525 Paracoccidioides sp. 'lutzii' Pb01
9472946 Phytophthora infestans T30-4
9531294 Verticillium alfalfae VaMs.102
10031944 Arthroderma gypseum CBS 118893
10374056 Trichophyton rubrum CBS 118892
100172090 Pongo abelii
13360 Mus musculus
64191 Rattus norvegicus
1717 Homo sapiens
422982 Gallus gallus
483675 Canis lupus familiaris
514745 Bos taurus
379273 Xenopus laevis
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