Analytical Tools for RNA Therapeutics
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We are offering the best products out there against more than 90,000 targets, from >2000 species, for >300 applications. antibodies-online.com is a true Single Source when working on the protein level and we continue to build an exclusive and unique line of products at the cutting edge of science. If you cannot find an antibody from our extensive antibody catalog to suit your research needs, then our custom recombinant antibody service team can help. Having the right, high-quality antibody or protein for the right application can make the difference between success or failure in your experiment.
Explore our Custom Solutions
Collaboration is the key to success in any type of research. We partnered with the US antibody expert Rockland Immunochemicals, Inc. (Rockland) to provide you with a variety of custom services tailored to your experimental needs. Explore our combined extensive range of validated specialty reagents, including ModDetect™ panels, and take advantage of our custom antibody production and conjugation services, all tailored to advance your research in the dynamic field of RNA therapeutics.
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ModDetect™ Panels
Rockland’s readily available ModDetect™ specialty reagent panels detect many common nucleic acid modifications made to oligonucleotide therapeutics independent of the sequence or location of the modification.
Anti-Oligonucleotide Antibodies
Advance research and development of oligonucleotide-based therapeutics with sequence-specific or conformation-specific anti-oligonucleotide antibodies. We have a demonstrated history of generating anti-oligonucleotide antibodies with high specificity and sensitivity, and offer polyclonal, conventional monoclonal, or recombinant monoclonal formats.
The Immunoassay Advantage
Choosing oligonucleotide drug candidates during early discovery stages and further assessment of these candidates in the pre-clinical stages of drug development can be time-consuming and laborious. Moreover, assessing pharmacokinetics (PK) by further elucidating absorption, distribution, metabolic, and excretion (ADME) profiles of a given oligonucleotide or multiple oligonucleotides, in addition to understanding pharmacodynamic (PD) properties, and performing immunogenicity studies, is essential to the movement of the best candidates in the pipeline. Although current assays can address these parameters, they have certain disadvantages, such as the need for multiple probes, sequence specificity, decreased sensitivity for larger oligonucleotides, or handling and disposal of radioactive materials.
Immunoassays provide a novel approach for collecting critical data to further shed light on PK/ADME parameters, immunogenicity studies, and combat some disadvantages of the current methods; however, antibody development to oligonucleotides can be challenging and is typically specific to a particular sequence. Rockland has a demonstrated history of successful custom antibody generation against different nucleic acid targets, including modified oligonucleotides and nucleosides, heteroduplexes, and single-stranded and double-stranded DNA and RNAs.
Our Service Partner: Rockland
Our Service Partner: Rockland
Benefit from expertise over two generations of scientific advances. Rockland enabling biomolecule detection, characterization and analysis since 1962. 60,000 square feet manufacturing facility produce high-quality antibodies, reagents and custom services for your next project
Benefit from expertise over two generations of scientific advances. Rockland enabling biomolecule detection, characterization and analysis since 1962. 60,000 square feet manufacturing facility produce high-quality antibodies, reagents and custom services for your next project
