Angiotensin-converting enzyme, or ACE, is a central component of the renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. ACE inhibitors are of medical use as treatment of cardiovascular diseases...
Read MoreApoptosis is a highly regulated process offering an organized way for an organism to dispose of cells that are no longer needed. It is initiated either through a specific class of death receptors or intrinsic factors such as DNA damage. Apoptosis is mainly driven by caspase proteases and further regulated by Bcl-2 and inhibitor proteins. Dysregulation of this programmed cell death is oftentimes associated with cancer.
Read MoreAutophagy is the regulated, self-degradative process of the cell that disassembles unnecessary or dysfunctional components. The lysosomal pathway is evolutionarily conserved and initiates engulfment, degradation and recycling of cellular contents including long-lived proteins and organelles thus promoting cell survival.
Read MoreCell division unfolds in four stages - G1, S, G2, and M phase – depending on a number of internal or external signals. Progression through the different phases is driven by cyclin dependent kinases (CDK) and their activators, the cyclins. Additionally, their activity is further modulated by CDK inhibitors. Tight control of the cell cycle is essential to maintain proper cell homeostasis.
Read MoreThe complement system is part of the innate immune system and plays an important role in host defense, inflammation, tissue regeneration and other physiological processes. Depending on the invading pathogen it follows three established pathways: the classical, lectin, or alternative pathway.
Read MoreIn any organism, various DNA repair mechanisms assure the integrity of the genetic information that is contained in the nucleus of every cell. The crucial significance of keeping the DNA intact is reflected by the number of different DNA repair pathways and the various proteins involved in these processes.
Read MoreThe Hedgehog (Hh) signaling cascade is one of the most important determinants for many developmental processes. Gene products of the targeted genes determine cellular stemness, renewal, survival, and migration. Deregulation of the Hh signal proteins and downstream effectors is pivotal during cancer progression.
Read MoreJAK-STAT signaling is highly conserved in vertebrates and even some other metazoans. The combination of receptor activated kinases and transcription factors make this signaling cascade one of the central cellular regulatory pathways.
Read MorePhosphorylation is the reversible process of attaching a phosphate group to a specific amino-acid residue on a protein. Functionally, phosphorylation acts as a simple molecular switch that can activate, deactivate, or modulate the function of a protein. Addition and removal of phosphate groups provide spatial and temporal control over protein activity.
Read MoreMicrotubules are highly-dynamic structural and functional intracellular highways. The term cytoskeleton conjures up an image of rigid, immutable, and permanent structure. In reality, the cytoskeleton is a highly dynamic interconnected network composed of three different principal components: microtubules ...
Read MoreNF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) represent a group of homo- or heterodimeric transcription factors that are central in a network of various signal transduction pathways. A vast array of signals such as cytokines, growth factors and hormones, infections, oxidative stress,...
Read MoreThe highly-conserved Notch signaling pathway is unique, as both the Notch receptor and most of its respective ligands...
Read Morep53 is one of the most prominent tumor suppressors and is often called “the guardian of the genome”. Mutations of p53 or parts of its regulatory circuit are found in almost all cancers, which highlights its importance. It is conserving the stability of the genome by preventing mutations caused by cellular stress or DNA damage. p53 stabilizes the...
Read MoreThe PI3K/Akt pathway is pivotal for cellular homeostasis, neurological development, metabolism, and other processes. It regulates various aspects of cellular development such as apoptosis, cell cycle progression, and cell differentiation. The key regulator of the PI3K/Akt pathway is Akt/PKB, a family of three closely related serine/threonine-protein kinases...
Read MoreReceptor Tyrosine Kinases (RTKs) are membrane bound kinases that are activated upon binding of receptor specific ligands. They make up the largest class of membrane receptors that trigger signaling cascades through their inherent enzymatic activity.
Read MoreThe T-Cell Receptor is a protein complex on the surface of T-cell responsible for antigen recognition. The activation induces a number of signaling cascades finally leading to the transcription of several gene products which allow the T cells to differentiate, proliferate and secrete a number of cytokines.
Read MoreToll-like receptors play an essential in the innate immune response against various pathogens such as viruses, bacteria, and fungi. TLRs elicit one of two conserved inflammatory pathways: either the TRIF- or the MyD88 dependent pathway. Besides, TLR signaling also induces dendritic cell maturation and the adaptive immune response.
Read MoreThe unfolded protein response (UPR) is a cellular stress response activated in eukaryotic cells in response to endoplasmic reticulum (ER) stress, an accumulation of unfolded proteins in the ER lumen
Read MoreVascular endothelial growth factors (VEGFs) constitute a sub-family of growth factors that stimulate the growth of new blood vessels. VEGFs are important signaling proteins and initiate angiogenesis via several signalling cascades.
Read MoreWnts are a class of evolutionarily-conserved, lipid-modified glycoproteins that play a pivotal role in development and homeostasis through a number of different paracrine...
Read MoreBrowse our antibodies, ELISA kits and proteins related to activated T cell proliferation.
Read MoreBrowse our antibodies, ELISA kits and proteins related to the activation of innate immune response.
Read MoreBrowse our antibodies, ELISA kits and proteins related to asymmetric protein localization.
Read MoreBrowse our antibodies, ELISA kits and proteins related to brown fat cell differentiation.
Read MoreBrowse our antibodies, ELISA kits and proteins related to C21-steroid hormone metabolic process.
Read MoreBrowse our antibodies, ELISA kits and proteins related to cAMP metabolic process.
Read MoreBrowse our antibodies, ELISA kits and proteins related to carbohydrate homeostasis.
Read MoreBrowse our Caspase cascade related antibodies and ELISA kits.
Read MoreBrowse our antibodies and ELISA kits related to cell redox homeostasis.
Read MoreBrowse our antibodies, ELISA kits and proteins related to cell-cell junction organization.
Read MoreBrowse our antibodies, ELISA kits and proteins related to cellular glucan metabolic process.
Read MoreBrowse our antibodies, ELISA kits and proteins related to the cellular response to molecule of bacterial origin.
Read MoreBrowse our antibodies, ELISA kits and proteins related to chromatin binding.
Read MoreBrowse our antibodies, ELISA kits and proteins related to CXCR4-mediated signaling events.
Read MoreBrowse our antibodies, ELISA kits and proteins related to dicarboxylic acid transport.
Read MoreBrowse our antibodies, ELISA kits and proteins related to DNA replication.
Read MoreBrowse our antibodies, ELISA kits and proteins related to Dopaminergic Neurogenesis.
Read MoreBrowse our antibodies, ELISA kits and proteins related to EGFR downregulation.
Read MoreBrowse our EGFR signaling pathway related antibodies and ELISA kits.
Read MoreBrowse our antibodies, ELISA kits and proteins related to embryonic body morphogenesis.
Read MoreBrowse our antibodies, ELISA kits and proteins related to the ER-nucleus signaling pathway.
Read MoreBrowse our Fc-epsilon Receptor Signaling Pathway related antibodies and ELISA kits.
Read MoreBrowse our antibodies, ELISA kits and proteins related to feeding behaviour.
Read MoreBrowse our antibodies, ELISA kits and proteins related to G-protein mediated events.
Read MoreBrowse our antibodies, ELISA kits and proteins related to glycosaminoglycan metabolic process.
Read MoreBrowse our antibodies, ELISA kits and proteins related to growth factor binding.
Read MoreBrowse our antibodies, ELISA kits and proteins related to hormone activity.
Read MoreBrowse our antibodies, ELISA kits and proteins related to hormone transport.
Read MoreBrowse our antibodies, ELISA kits and proteins related to inositol metabolic process.
Read MoreBrowse our antibodies, ELISA kits and proteins related to the integrin complex.
Read MoreBrowse our antibodies, ELISA kits and proteins related EGFR and its interaction with phospholipase C-gamma.
Read MoreBrowse our intracellular steroid hormone receptor signaling pathway related antibodies and ELISA kits.
Read MoreBrowse our antibodies, ELISA kits and proteins related to maintenance of protein location.
Read MoreBrowse our products related to metabolism of steroid hormones and vitamin D.
Read MoreBrowse our antibodies, ELISA kits and proteins related to the methionine biosynthetic process.
Read MoreBrowse our antibodies, ELISA kits and proteins related to mitotic G1-G1/S phases.
Read MoreBrowse our antibodies, ELISA kits and proteins related to the monocarboxylic acid catabolic process.
Read MoreBrowse our antibodies, ELISA kits and proteins related to myometrial relaxation and contraction pathways.
Read MoreBrowse our antibodies, ELISA kits and proteins related to negative regulation of hormone secretion.
Read MoreBrowse our antibodies, ELISA kits and proteins related to negative regulation of intrinsic apoptotic signaling.
Read MoreBrowse our antibodies and ELISA kits related to negative regulation of transporter activity.
Read MoreBrowse our neurotrophin signaling pathway related antibodies and ELISA kits.
Read MoreBrowse our antibodies, ELISA kits and proteins related to nuclear hormone receptor binding.
Read MoreBrowse our nuclear receptor transcription pathway related antibodies and ELISA kits.
Read MoreBrowse our antibodies, ELISA kits and proteins related to Nucleotide Phosphorylation.
Read MoreBrowse our peptide hormone metabolism related antibodies and ELISA kits.
Read MoreBrowse our antibodies, ELISA kits and proteins related to phototransduction.
Read MoreBrowse our antibodies, ELISA kits and proteins related to platelet-derived growth factor receptor signaling.
Read MoreBrowse our antibodies, ELISA kits and proteins related to positive regulation of endopeptidase activity.
Read MoreBrowse our antibodies, ELISA kits and proteins related to growth factor binding.
Read MoreBrowse our antibodies, ELISA kits and proteins related to the positive regulation of immune effector process.
Read MoreBrowse our antibodies and ELISA kits related to positive regulation of peptide hormone secretion.
Read MoreBrowse our antibodies, ELISA kits and proteins related to positive regulation of response to DNA damage stimulus.
Read MoreBrowse our antibodies, ELISA kits and proteins related to the production of molecular mediator of immune response.
Read MoreBrowse our antibodies, ELISA kits and proteins related to the protein targeting to nucleus.
Read MoreBrowse our antibodies, ELISA kits and proteins related to proton transportation.
Read MoreBrowse our antibodies, ELISA kits and proteins related to the regulation of actin filament polymerization.
Read MoreBrowse our antibodies, ELISA kits and proteins related to the regulation of carbohydrate metabolic process.
Read MoreBrowse our antibodies, ELISA kits and proteins related to the regulation of cell size.
Read MoreBrowse our antibodies, ELISA kits and proteins related to the regulation of G-protein coupled receptor protein signaling.
Read MoreBrowse our antibodies, ELISA kits and proteins related to the regulation of hormone biosynthetic processes.
Read MoreBrowse our antibodies, ELISA kits and proteins related to the regulation of hormone metabolic processes.
Read MoreBrowse our antibodies, ELISA kits and proteins related to regulation of intracellular steroid hormone receptor signaling.
Read MoreBrowse our antibodies, ELISA kits and proteins related to regulation of leukocyte mediated immunity.
Read MoreBrowse our antibodies, ELISA kits and proteins related to the Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
Read MoreBrowse our antibodies, ELISA kits and proteins related to regulation of long-term neuronal synaptic plasticity.
Read MoreBrowse our antibodies, ELISA kits and proteins related to regulation of muscle cell differentiation.
Read MoreBrowse our antibodies, ELISA kits and proteins related to the regulation of systemic arterial blood pressure by hormones.
Read MoreBrowse our Regulatory RNA Pathway related antibodies and ELISA kits.
Read MoreBrowse our antibodies, ELISA kits and proteins related to response to growth hormone stimulus.
Read MoreBrowse our antibodies, ELISA kits and proteins related to the response to water deprivation.
Read MoreBrowse our retinoic acid Receptor signaling pathway related antibodies and ELISA kits.
Read MoreBrowse our antibodies, ELISA kits and proteins related to the ribonucleoprotein complex subunit organization.
Read MoreBrowse our antibodies, ELISA kits and proteins related to ribonucleoside biosynthetic process.
Read MoreBrowse our antibodies, ELISA kits and proteins related to ribosome assembly.
Read MoreBrowse our antibodies, ELISA kits and proteins related to the sensory perception of sound.
Read MoreBrowse our antibodies, ELISA kits and proteins related to signaling events mediated by VEGFR1 and VEGFR2.
Read MoreBrowse our antibodies, ELISA kits and proteins related to signaling of Hepatocyte Growth Factor receptor.
Read MoreBrowse our antibodies, ELISA kits and proteins related to skeletal muscle fiber development.
Read MoreBrowse our antibodies, ELISA kits and proteins related to smooth muscle cell migration.
Read MoreBrowse our antibodies, ELISA kits and proteins related to stem cell maintenance.
Read MoreBrowse our antibodies and ELISA kits related to steroid hormone biosynthesis.
Read MoreBrowse our antibodies and ELISA kits related to steroid hormone mediated signaling pathway.
Read MoreBrowse our antibodies, ELISA kits and proteins related to synaptic membranes.
Read MoreBrowse our antibodies, ELISA kits and proteins related to synaptic vesicle exocytosis.
Read MoreBrowse our antibodies, ELISA kits and proteins related to Thromboxane A2 receptor signaling.
Read MoreBrowse our antibodies, ELISA kits and proteins related to thyroid hormone synthesis.
Read MoreBrowse our antibodies, ELISA kits and proteins related to toll-like receptors cascades.
Read MoreBrowse our antibodies, ELISA kits and proteins related to transition metal ion homeostasis.
Read MoreBrowse our antibodies, ELISA kits and proteins related to VEGFR1 specific signals.
Read More