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Aminolevulinate, delta-, Synthase 2 (ALAS2) ELISA Kits

The product of ALAS2 specifies an erythroid-specific mitochondrially located enzyme. Additionally we are shipping ALAS2 Antibodies (60) and ALAS2 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ALAS2 212 P22557
ALAS2 25748 Q63147
ALAS2 11656 P08680
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Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
96 Tests Log in to see 11 to 13 Days

More ELISA Kits for ALAS2 Interaction Partners

Human Aminolevulinate, delta-, Synthase 2 (ALAS2) interaction partners

  1. data indicate that the X-linked protoporphyria (show FECH ELISA Kits) variants possess enhanced ALAS activity and ALA dissociation rates, as well as distinct structural properties from those of wild-type hALAS

  2. In this article we add a novel mutation to the previously described 61 different ALAS2 mutations identified in X-linked sideroblastic anaemia patients.

  3. the primary deficiency in ferrochelatase (show FECH ELISA Kits) leads to a secondary increase in ALAS2 expression.

  4. The ALAS2 Y365C mutation impairs pyridoxal 5'-phosphate binding to ALAS2, destabilizing the enzyme. X inactivation was not highly skewed in WBC from affected women. This X-linked dominant mutation perturbs erythropoiesis via cell-nonautonomous effects.

  5. the 130-base pair enhancer region located in the first intron of the ALAS2 gene should be examined in patients with congenital sideroblastic anemia in whom the gene responsible is unknown.

  6. 5 families with X-linked sideroblastic anemia had mutations in a GATA transcription factor binding site located in a transcriptional enhancer element in intron 1 of the ALAS2 gene.

  7. Loss-of-function FECH (show FECH ELISA Kits) and gain-of-function erythroid-specific ALAS2 mutations causing erythropoietic protoporphyria (show FECH ELISA Kits) and x-linked protoporphyria (show FECH ELISA Kits) in North American patients reveal novel mutations and a high prevalence of X-linked protoporphyria (show FECH ELISA Kits).

  8. ALAS2 gain-of-function mutations increas the specific activity (DeltaAT, DeltaAGTG and p.Q548X) or stability (DeltaG) of the enzyme, thereby leading to the increased erythroid protoporphyrin accumulation causing X-linked protoporphyria (show FECH ELISA Kits).

  9. A large gain-of-function domain within the C-terminus of ALAS2 is associated with X-linked dominant protoporphyria (show FECH ELISA Kits).

  10. Late-onset photosensitivity was caused by ALAS2 mutation in a family with dominant protoporphyria (show FECH ELISA Kits).

Xenopus laevis Aminolevulinate, delta-, Synthase 2 (ALAS2) interaction partners

  1. Xalas2 might be able to synthesize hemoglobin (show HBB ELISA Kits) during hematopoiesis and mediate erythrocyte differentiation by regulating hba3 expression in Xenopus laevis

Mouse (Murine) Aminolevulinate, delta-, Synthase 2 (ALAS2) interaction partners

  1. We propose that the N-terminal truncation offers a cell-specific ALAS2 regulatory mechanism without hindering heme synthesis

  2. Light treatments revealed that ALAS2 expression results in an increase in cell death in comparison to aminolevulinic acid (ALA) treatment producing a similar amount of protoprophyrin IX.

  3. The rate of ALA release is also controlled by a hysteretic kinetic mechanism (observed as a lag (show STMN1 ELISA Kits) in the ALA external aldimine formation progress curve), consistent with conformational changes governing the dissociation of ALA from ALAS.

  4. impaired mitochondrial [Fe-S] cluster biogenesis in Mfrn1 (show SLC25A37 ELISA Kits)(gt/gt (show FABP6 ELISA Kits)) cells results in elevated IRP1 (show ACO1 ELISA Kits) RNA-binding that attenuates ALAS2 mRNA translation and protoporphyrin accumulation

  5. Aberrant iron accumulation and peroxidized state of (ALAS2)-deficient definitive erythroblasts

  6. Gene expression and enzymatic assays indicate that erythroid 5-aminolevulinic acid synthase (Alas2) is decreased in hem6 animals, suggesting a mechanism that could account for the anemia.

ALAS2 Antigen Profile

Antigen Summary

The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with ALAS2

  • aminolevulinate, delta-, synthase 2 (alas2) antibody
  • aminolevulinate, delta-, synthase 2 (ALAS2) antibody
  • aminolevulinate, delta-, synthase 2 (Alas2) antibody
  • aminolevulinate, delta-, synthetase 2 (alas2) antibody
  • aminolevulinic acid synthase 2, erythroid (Alas2) antibody
  • ALAS antibody
  • Alas-2 antibody
  • alas-e antibody
  • ALASE antibody
  • ANH1 antibody
  • ASB antibody
  • cb1063 antibody
  • sau antibody
  • sauternes antibody
  • XLDPP antibody
  • XLEPP antibody
  • XLSA antibody

Protein level used designations for ALAS2

5-aminolevulinate synthase 2 , aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) , 5-aminolevulinate synthase, erythroid-specific, mitochondrial , aminolevulinate, delta-, synthase 2 , ALAS-E , delta-ALA synthase 2 , 5-aminolevulinic acid synthase 2 , delta-aminolevulinate synthase 2 , 5-aminolevulinate synthase, erythroid-specific, mitochondrial-like , delta-ALA synthetase , delta-ALA synthetase 2 , Aminolevulinate synthase 2, delta , aminolevulinic acid synthase 2, erythroid , erythroid-specific delta-aminolevulinate synthase ALAS-E , erythroid aminolevulinate synthase , erythroid-specific ALAS

448773 Xenopus (Silurana) tropicalis
473626 Pan troglodytes
704727 Macaca mulatta
100060580 Equus caballus
100174709 Pongo abelii
100410919 Callithrix jacchus
100606858 Nomascus leucogenys
212 Homo sapiens
511791 Bos taurus
25748 Rattus norvegicus
447323 Xenopus laevis
491498 Canis lupus familiaris
64607 Danio rerio
11656 Mus musculus
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