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The protein encoded by APOA is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. Additionally we are shipping Apolipoprotein A Antibodies (50) and Apolipoprotein A Kits (11) and many more products for this protein.
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tests of association using logistic regression assuming an additive genetic model revealed no significant associations (p<0.05) for any of the five LPA variants previously associated with Lp(a) levels in African Americans
These data demonstrate that serum Lp(a) is elevated in patients with FH caused by PCSK9 (show PCSK9 Proteins) gain-of-function mutations to the same level as that in FH caused by LDLR (show LDLR Proteins) mutations.
study provides evidence that ancestry-specific causal risk variant(s) resides in or near LPA and that most of the observed associations outside this narrower region are spurious associations.
Data suggest plasma levels of PCSK9 (proprotein convertase subtilisin/kexin type 9 (show PCSK9 Proteins)) and lipoprotein(a) are significantly up-regulated in patients with type 2 diabetes as compared to control subject; study was conducted in Tunisia.
oxLp(a) induced autophagy via LKB1 (show STK11 Proteins)-AMPK (show PRKAA1 Proteins)-mTOR (show FRAP1 Proteins) and PAPR-1-LKB1 (show STK11 Proteins)-AMPK (show PRKAA1 Proteins)-mTOR (show FRAP1 Proteins) pathways, which are dependent on ROS (show ROS1 Proteins) generation
LPA rs3798220 does not appear to be associated with small apolipoprotein(a) isoforms and high lipoprotein(a) levels in East and Southeast Asians
Elevated Lp(a) is an independent risk factor for ischemic stroke and may be especially relevant for young stroke patients [meta-analysis]
apo(a) has a plasma residence time that is more than twice as long as that of apoB (show APOB Proteins)-100within Lp(a)
Apolipoprotein(a) Kringle-IV Type 2 Copy Number Variation Is Associated with Venous Thromboembolism
Increased serum Lp(a) levels were independent predictors of deep vein thrombosis in patients with spinal cord injuries in China
The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence.
antiangiogenic AK38 protein