Apolipoprotein A Proteins (APOA)

The protein encoded by APOA is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. Additionally we are shipping Apolipoprotein A Antibodies (42) and Apolipoprotein A Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID
APOA 4018
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Top Apolipoprotein A Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 50 μg Log in to see 2 to 3 Days
$310.00
Details
HOST_Human Human Un-conjugated 1 mg Log in to see 11 to 12 Days
$434.50
Details
HOST_Human Human Un-conjugated 1 mg Log in to see 11 to 16 Days
$350.63
Details

APOA Proteins by Origin and Source

Origin Expressed in
Human ,

More Proteins for Apolipoprotein A (APOA) Interaction Partners

Human Apolipoprotein A (APOA) interaction partners

  1. Due to new therapies that lower Lp(a) levels, there is renewed interest and still rising research activity in Lp(a). Despite all these activities, numerous gaps exist in our knowledge, especially as far as the function and metabolism of this fascinating Lp are concerned.

  2. This discovery has sparked intense interest in Lp(a) as a modifiable cause for aortic valve disease. Herein, we will review the mounting epidemiological and genetic findings in support of Lp(a)-mediated valve disease, discuss potential mechanisms underlying this observation, and outline the steps to translate this discovery to a much needed novel preventive and/or therapeutic strategy for aortic valve disease.

  3. Levels of lipoprotein (a) [Lp(a)], a complex between an LDL-like lipid moiety containing one copy of apoB (show APOB Proteins), and apo(a), a plasminogen (show PLG Proteins)-derived carbohydrate-rich hydrophilic protein, are primarily genetically rIncreasing evidence suggests that age, sex, and hormonal impact may have a modest modulatory influence on Lp(a) levels. Among clinical conditions, Lp(a) levels are reported to be affected by kidney and liver diseases.

  4. these studies support that reductions in Lp(a) with PCSK9 (show PCSK9 Proteins) inhibition are partly due to increased LDLR (show LDLR Proteins)-mediated uptake. In most situations, Lp(a) appears to compete poorly with LDL for LDLR (show LDLR Proteins) binding and internalization, but when LDLR (show LDLR Proteins) expression is increased with evolocumab, particularly in the setting of low circulating LDL, Lp(a) is reduced.

  5. Elevated Lp(a) level was an independent predictable risk factor for cardiovascular disease in type 2 diabetes.

  6. Recent genetic evidence documents elevated Lp(a) as a cause of myocardial infarction, atherosclerotic stenosis, and aortic valve stenosis

  7. APOE (show APOE Proteins) genotypes strongly influence Lp(a) and apoB (show APOB Proteins)-related lipoprotein levels.

  8. Lipoprotein apheresis has a lasting effect on prevention of cardiovascular events in patients with Lp(a)-hyperlipoproteinemia.

  9. The genotype of rs3088442 within the SLC22A3-LPAL2-LPA gene cluster may contribute to regulation of plasma Lp(a) levels and possibly to the severity of coronary artery disease in a Chinese Han population.

  10. Lp(a) levels of >30 and >50 mg/dL were fairly common, particularly in a tertiary care setting.

Apolipoprotein A (APOA) Protein Profile

Protein Summary

The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence.

Gene names and symbols associated with Apolipoprotein A Proteins (APOA)

  • lipoprotein, Lp(a) (LPA)
  • AK38 protein
  • Apo(a) protein
  • APOA protein
  • LP protein
  • Lp(a) protein

Protein level used designations for Apolipoprotein A Proteins (APOA)

antiangiogenic AK38 protein , apo(a) , apolipoprotein(a) , lp(a)

GENE ID SPECIES
4018 Homo sapiens
709528 Macaca mulatta
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