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APOB product is the main apolipoprotein of chylomicrons and low density lipoproteins. Additionally we are shipping APOB Antibodies (357) and APOB Kits (119) and many more products for this protein.
Showing 10 out of 26 products:
Multiple novel LDLR (show LDLR Proteins) and ApoB mutations have been identified in a-United Kingdom-based cohort with familial hypercholesterolemia.
Data suggest that LDL-C/apoB ratio (ratio of plasma level of total cholesterol to plasma level of apolipoprotein B) is an important biomarker in overall evaluation of atherogenicity in obese, overweight, and normal-weight men; this study of qualitative changes in lipid/lipoprotein profile for early diagnosis of dyslipidemias leading to atherosclerosis was conducted in Russia.
Mutations in APOB is associated with hypobetalipoproteinemia.
LDLR (show LDLR Proteins) A(+)A(+) genotype, ApoB X(+) allele and ApoE (show APOE Proteins) E4 allele increased the risk of premature coronary artery disease by 1.8, 2.1 and 12.1 respectively.
C7673T polymorphism in apoB gene is significantly associated with increased ischemic stroke risk in the Chinese population.
Apo-B correlation with both LDL-C and non-HDL-C is reduced in individuals with high TG levels and in particular for those with diabetes or MetS.
Report increased intestinal cholesterol absorption and elevated serum cholesterol in families with primary hypercholesterolemia without mutations in APOB.
associations between apolipoprotein B, A1, and the B/A1 ratio and nonalcoholic fatty liver disease in both normal-weight and overweight Korean population
Data indicate that serum apolipoproteins ApoB, ApoA-1 (show APOA1 Proteins) and ApoB/A-1 ratio levels are independently associated with coronary heart disease (CHD (show CHDH Proteins)) risk in Korean men.
Low plasma concentration of PTX3 (show PITX3 Proteins) in early pregnancy is associated with subsequent development of gestational diabetes and with an enhanced risk for CVD as estimated by an elevated apoB/apoA (show APOA Proteins) ratio at 5 years postpartum.
A transposable element insertion in APOB causes cholesterol deficiency in Holstein cattle
Nonesterified fatty acids significantly inhibit the expression of ApoB100, ApoE (show APOE Proteins), MTP (show MTTP Proteins), and LDLR (show LDLR Proteins), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
after calving the apolipoprotein B(100) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (show MTTP Proteins)) and apolipoprotein E (show APOE Proteins) messenger RNA abundance were higher in the liver.
The effect of hypercholesterolemia induced immune response and inflammation on progression of atherosclerosis in ApoB(tm25gy) LDLr (show LDLR Proteins)(tm1Her) mice, expressing only ApoB100 and deficient in the low density lipoprotein receptor (show LDLR Proteins).
ApoB-containing lipoproteins contribute to augmentation of AngII-induced abdominal aortic aneurysms in male mice.
Immunization with human apolipoprotein B100 (ApoB) resulted in four-fold increased accumulation of effector T cells in ApoB-containing matrigel
PCSK9 (show PCSK9 Proteins) markedly increases intestinal triglyceride-rich apoB production through mechanisms mediated in part by transcriptional effects on apoB.
Mice that produce apoB100 in the RPE (show RPE Proteins) and liver secrete lipoproteins into Bruch's membrane, but not to the extent that distinct features of AMD (show AMD1 Proteins) develop
The aim of this study was to characterize the ocular morphology of low-density lipoprotein receptor-deficient apolipoprotein B-100-only mice, with IGF-II overexpression.
Our data establish the role of APOB gene in severe gut (show GUSB Proteins) dysmotility.
Cardiac lipotoxicity may originate from direct inhibition of myocardial ApoB lipoprotein and subsequent decreased lipid export, caused by supraphysiological levels of catecholamines.
ApoB-100 transgenic animals present i) elevated serum and cerebral levels of triglycerides and ApoB-100, ii) increased cerebral tau phosphorylation at phosphosites Ser (show SIGLEC1 Proteins)(199), Ser (show SIGLEC1 Proteins)(199/202), Ser (show SIGLEC1 Proteins)(396) and Ser (show SIGLEC1 Proteins)(404).
model in which increased hepatic sortilin (show SORT1 Proteins) binds intracellular APOB-containing particles in the Golgi apparatus as well as extracellular LDL at the plasma membrane and traffics them to the lysosome for degradation
found association between genotypes for LDLR (show LDLR Proteins) and APOB polymorphisms and serum lipid levels, but none of them seem to be the causal mutation but probably represent closely linked polymorphisms
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.
, apolipoprotein B (including Ag(x) antigen)
, apolipoprotein B-100
, apolipoprotein B48
, mutant Apo B 100
, apolipoprotein B PI
, apolipoprotein B-48
, apolipoprotein B