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Aryl Hydrocarbon Receptor Nuclear Translocator Proteins (ARNT)

The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. Additionally we are shipping ARNT Antibodies (166) and ARNT Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ARNT 405 P27540
ARNT 11863 P53762
ARNT 25242 P41739
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Top ARNT Proteins at

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

ARNT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
Mouse (Murine)

Rat (Rattus)

Top referenced ARNT Proteins

  1. Human ARNT Protein expressed in Wheat germ - ABIN1345671 : Yang, Li, Yin, Huang, Sun, Li: A new method to assay hypoxia-inducible factor-1 based on small molecule binding DNA. in Analytica chimica acta 2014 (PubMed)

More Proteins for Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Interaction Partners

Zebrafish Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) interaction partners

  1. Morpholino experiments show that knockdown of ARNT1 offers protection from TCCD-induced cardiotoxicity.

Human Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) interaction partners

  1. The results of this study indicate that ARNT depletion renders tumour cells susceptible to radiation whereas overexpression of this transcription factor confers radioresistance

  2. HIF-1beta might act as a novel cross-link between the HIF and NF-kappaB (show NFKB1 Proteins) pathways in suppression of angiogenesis by LDL, while proteasome inhibitors might promote angiogenesis by reactivating this signaling cascade under hyperlipidemia.

  3. ARNT Val189Val polymorphism is not associated with endometriosis in Asians.

  4. HIF1 (show HIF1A Proteins) regulates claudin-1 (show CLDN7 Proteins) in intestinal epithelium. This regulation is important for intestinal epithelial tight junction integrity.

  5. Down-regulation of ARNT promotes colorectal cancer metastasis by activating the fibronectin (show FN1 Proteins)/integrin beta1/FAK (show PTK2 Proteins) axis.

  6. AhR (show AHR Proteins)/ARNT activation and overexpression of BCL6 (show BCL6 Proteins) are collectively responsible for differential expression of more than 100 genes in diffuse large B-cell lymphoma cell line.

  7. Data indicate that silencing of hypoxia-inducible factor-1 beta (HIF-1beta) sensitizes tumor cells to hypoxic apoptosis.

  8. ARNT expression in the placental vasculature mediates key angiogenic expression and fetoplacental endothalial cell angiogenesis, and low ARNT expression in FGRadv ECs appears to be a key factor in deficient angiogenesis.

  9. findings suggest that TACC3 (show TACC3 Proteins) could be recruited as a bridge to cooperatively mediate between the HIF-2alpha (show EPAS1 Proteins) PAS (show PASK Proteins)-B.ARNT PAS (show PASK Proteins)-B complex, thereby participating more directly in HIF-dependent gene transcription than previously anticipated

  10. The objective of this review is therefore to highlight and summarize current knowledge regarding the hypoxia-dependent upregulation of ARNT

Mouse (Murine) Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) interaction partners

  1. These promoters possess potential signature sequences for common as well as different transcription factors suggesting complex regulation of Arnt gene.

  2. The only in vivo defects found in beta-Arnt mice were significant increases in the respiratory exchange ratio and in vivo carbohydrate oxidation, and a decrease in lipid oxidation

  3. hepatocyte ARNT is not a requirement for initiation of liver fibrogenesis, but does regulate pro-fibrotic gene expression and macrophage accumulation.

  4. HIF-1beta hepatocyte-specific knockout mice had less liver injury and steatosis in response to Gao-binge ethanol treatment.

  5. Candidate gene analysis focused on Arnt as an influence on circadian regulation in the 'drinking in the dark' phenotype of alcohol consumption.

  6. crystal structures for each of mouse HIF-2alpha (show EPAS1 Proteins)-ARNT and HIF-1alpha (show HIF1A Proteins)-ARNT heterodimers in states that include bound small molecules and their hypoxia response element

  7. We determined that ARNT is essential for adult and fetal hematopoietic stem cell viability and homeostasis.

  8. ARNT is a critical regulator of myocardial fatty acid metabolism and its deletion leads to cardiomyopathy and an increase in triglyceride accumulation through PPARA (show PPARA Proteins).

  9. This study demonstrates for the first time the requirement of HIF1 for FSH (show BRD2 Proteins)-regulated Vegfa (show VEGFA Proteins) expression in vivo and that HIF1 acts via a single hypoxia response element in the Vegfa (show VEGFA Proteins) promoter to exert its regulatory functions.

  10. Outcomes for islet transplants lacking beta-cell ARNT were poor.

ARNT Protein Profile

Protein Summary

The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t(1\;12)(q21\;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with ARNT

  • aryl hydrocarbon receptor nuclear translocator (ARNT)
  • aryl hydrocarbon receptor nuclear translocator (arnt)
  • aryl hydrocarbon receptor nuclear translocator (Arnt)
  • Arnt (AHA-1)
  • ARNT protein
  • Arnt1 protein
  • bHLHe2 protein
  • D3Ertd557e protein
  • Drnt protein
  • ESTM42 protein
  • HIF-1-beta protein
  • HIF-1beta protein
  • HIF1-beta protein
  • Hif1b protein
  • HIF1BETA protein
  • mKIAA4051 protein
  • TANGO protein
  • W08714 protein
  • xArnt protein
  • zgc:136664 protein

Protein level used designations for ARNT

aryl hydrocarbon receptor nuclear translocator , ARNT1 , aryl hydrocarbon receptor nuclear translocater , ARNT protein , HIF-1 beta , HIF-1-beta , HIF1-beta , dioxin receptor, nuclear translocator , hypoxia-inducible factor 1 beta , hypoxia-inducible factor 1-beta , class E basic helix-loop-helix protein 2 , hypoxia-inducible factor 1, beta subunit , Aryl hydrocarbon receptor nuclear translocator 1 , rtARNT

374026 Gallus gallus
493634 Danio rerio
100144695 Xenopus (Silurana) tropicalis
100379223 Cavia porcellus
100008996 Oryctolagus cuniculus
405 Homo sapiens
11863 Mus musculus
25242 Rattus norvegicus
281010 Bos taurus
100136759 Oncorhynchus mykiss
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