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BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) Proteins (BAP1)

The protein encoded by BAP1 localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). Additionally we are shipping BAP1 Antibodies (127) and BAP1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BAP1 104416 Q99PU7
BAP1 8314 Q92560
BAP1 306257 D3ZHS6
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Top BAP1 Proteins at

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 to 8 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

BAP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
Rat (Rattus)

More Proteins for BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) Interaction Partners

Mouse (Murine) BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) interaction partners

  1. BAP1(+/-) mice exposed to low-dose asbestos fibers showed an altered peritoneal inflammatory response and higher levels of pro-tumorigenic alternatively polarized M2 macrophages, and lower cytokine levels. They had a higher incidence of mesothelioma.

  2. Bap1 loss led to a fully penetrant myeloproliferative disease with splenomegaly, leukocytosis, anemia and progenitor expansion via alterations in histone methylation and gene expression.

  3. INO80 is stabilized and targeted to replication forks by BAP1 during normal DNA synthesis but downregulated in BAP1 defective cancer cells

  4. Both Vhl (show VHL Proteins) and Bap1 are required for kidney function. Inactivation of Bap1 in neprhon progenitor cells causes renal failure earlier than Vhl (show VHL Proteins) inactivation. Bap1 is also a stronger tumor suppressor gene than Vhl (show VHL Proteins) in the kidney.

  5. Drawing parallels to human disease, these unbiased genetic findings indicate that BAP1 mutation carriers are predisposed to the tumorigenic effects of asbestos and suggest that high penetrance of mesothelioma requires such environmental exposure.

  6. Cx32 (show GJB1 Proteins) expression is in part related to induction of tight junctions through modulation of Magi1 (show CNKSR3 Proteins) expression in an immortalized hepatic cell line.

  7. ARIP1 (show MAGI2 Proteins) and ARIP2 (show SYNJ2BP Proteins) are co-expressed in some nerve cells and their biological activities are distinct.

  8. results identify a potent tumor suppressor function for BAP1 in myeloid neoplasia; propose that BAP1 forms a core complex with HCF-1 (show HCFC1 Proteins) and OGT (show OGT Proteins) that can differentially recruit additional histone-modifying enzymes to regulate gene expression and preserve norm

  9. Data conclude that the up-regulation of sdk-1 in podocytes is an important pathogenic factor in glomerulosclerosis and that the mechanism involves disruption of the actin cytoskeleton possibly via alterations in MAGI-1 (show CNKSR3 Proteins) function.

  10. Depletion of MAGI-1 (show CNKSR3 Proteins) from photorecptors by RNA interference blocks synaptic localization of Sidekick-2 in photoreceptors without affecting localization of postsynaptic density (PSD)-95 (show DLG4 Proteins).

Human BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) interaction partners

  1. Our cohort included 257 lung cancer patients, of which 155 (60%) were adenocarcinomas and 72 (28%) were squamous cell carcinomas, with no other subtype comprising more than 3%. BAP1 (show RNF2 Proteins) loss of expression was found in only one lung cancer. We conclude that BAP1 (show RNF2 Proteins) mutation occurs very infrequently (0.4%) in non-small cell lung cancer.

  2. expression of BAP1 (show RNF2 Proteins) is downregulated in gastric adenocarcinoma and its decreased expression is associated with more advanced tumor progressions (advanced T category, M category, and TNM (show ODZ1 Proteins) stage) and malignant phenotypes (histologic grade). Additionally, low BAP1 (show RNF2 Proteins) expression is correlated to poor prognosis in gastric adenocarcinoma.

  3. FISH analysis of the p16/CDKN2A status and BAP1 immunohistochemistry in the spindled mesothelium provide a more objective means to differentiate between biphasic mesothelioma and epithelioid mesothelioma with atypical stromal cells

  4. BAP1 (show RNF2 Proteins) mutation is associated with melanocytic tumors of the central nervous system.

  5. Data showed that patients with biallelic BAP1 (show RNF2 Proteins) mutation had the worse recurrence-free survival.

  6. BAP1 (show RNF2 Proteins) mutations responsible for tumor predisposition syndrome were reported in 2 families.

  7. BAP1 (show RNF2 Proteins) mutations occurred in asbestos-exposed malignant mesothelioma.

  8. Whole-exome sequencing of these lesions revealed the acquisition of BAP1 (show RNF2 Proteins) and TP53 (show TP53 Proteins) mutations during tumor evolution, thereby unmasking clonal heterogeneity and allowing the identification of cooperating genes within the same tumor.

  9. Unusually high frequency of large deletions indicates that the 3p21 chromosomal region surrounding BAP1 (show RNF2 Proteins) gene is structurally unstable.

  10. BAP1 (show RNF2 Proteins) immunohistochemistry is relatively insensitive in the context of differential diagnosis of sarcomatous and desmoplastic mesotheliomas.

BAP1 Protein Profile

Protein Summary

The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene.

Gene names and symbols associated with BAP1

  • Brca1 associated protein 1 (Bap1)
  • BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (BAP1)
  • BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (Bap1)
  • BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (bap1)
  • membrane associated guanylate kinase, WW and PDZ domain containing 1 (Magi1)
  • 2300006C11Rik protein
  • AA989761 protein
  • AIP3 protein
  • AW553466 protein
  • Baiap1 protein
  • BAIAP3 protein
  • BAP1 protein
  • Gukmi1 protein
  • hucep-6 protein
  • hucep-13 protein
  • Magi-1 protein
  • MAGI1c protein
  • mKIAA0272 protein
  • mKIAA4129 protein
  • si:dkey-42i9.9 protein
  • TNRC19 protein
  • uch-x4 protein
  • uchl2 protein
  • WWP3 protein

Protein level used designations for BAP1

BRCA1-associated protein 1 , ubiquitin C-terminal hydrolase X4 , ubiquitin carboxyl-terminal hydrolase BAP1 , cerebral protein 6 , cerebral protein-13 , Brca1 associated protein 1 , BAI1-associated protein 3 , ubiquitin carboxy-terminal hydrolase , BAI1-associated protein 1 , BAP-1 , guanylate kinase membrane-associated inverted 1 , membrane-associated guanylate kinase inverted 1 , membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

104416 Mus musculus
8314 Homo sapiens
484737 Canis lupus familiaris
306257 Rattus norvegicus
100124510 Bos taurus
415944 Gallus gallus
558885 Danio rerio
734438 Xenopus laevis
14924 Mus musculus
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