BRCA2 and CDKN1A Interacting Protein Proteins (BCCIP)

BCCIP product was isolated on the basis of its interaction with BRCA2 and p21 proteins. Additionally we are shipping BCCIP Antibodies (47) and BCCIP Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BCCIP 56647 Q9P287
BCCIP 66165 Q9CWI3
Rat BCCIP BCCIP 361666  
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Top BCCIP Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Baculovirus infected Insect Cells Human GST tag,His tag 100 μg Log in to see 20 to 21 Days
$437.80
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,816.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$388.93
Details

BCCIP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine)

More Proteins for BRCA2 and CDKN1A Interacting Protein (BCCIP) Interaction Partners

Human BRCA2 and CDKN1A Interacting Protein (BCCIP) interaction partners

  1. Expression of BCCIP beta was notably higher in tumor tissues of esophageal squamous cell carcinoma (ESCC) and Eca 109 cells. In vitro studies such as starvation and refeeding assay along with BCCIP beta-shRNA transfection assay demonstrated that BCCIP beta expression promoted proliferation of ESCC cells.

  2. we demonstrate that BCCIPbeta induces a conformational change within the RAD51 (show RAD51 Proteins) filament that promotes release of ADP to help maintain an active presynaptic filament. Our findings reveal a functional role for BCCIPbeta as a RAD51 (show RAD51 Proteins) accessory factor in HR.

  3. the existence of both INO80 and YY1 (show YY1 Proteins) is required for recruiting the INO80/YY1 (show YY1 Proteins) complex to BCCIP promoter region. Our findings strongly indicate that BCCIP is a potential target gene of the INO80/YY1 (show YY1 Proteins) complex.

  4. The BCCIPbeta, but not BCCIPalpha, interacts with EIF6 (show EIF6 Proteins) and RPL23 (show RPL17 Proteins)/UL14 and stabilizes the latter.

  5. Results indicate that BCCIP germ line mutations are unlikely to be a major contributor to familial breast/ovarian cancer risk in our population.

  6. In BRCA2 (show BRCA2 Proteins), two novel frame shift mutations were identified as 5073-5074delCT and 6866delC.

  7. BRCA2 (show BRCA2 Proteins) germline mutations appear to have a milder clinical phenotype when compared to non-BRCA2 (show BRCA2 Proteins) mutations, since survival is higher among breast cancer patients carrying a BRCA2 (show BRCA2 Proteins) mutation compared to sporadic breast cancers.

  8. Unique de novo mutation of BRCA2 (show BRCA2 Proteins) has been identified in a woman with early onset breast cancer.

  9. Overexpression of BCCIP beta delays the G1 to S progression and results in an elevated p21 (show CDKN1A Proteins) expression

  10. BCCIP is critical for BRCA2 (show BRCA2 Proteins)- and RAD51 (show RAD51 Proteins)-dependent responses to DNA damage and homologous recombinational repair.

Mouse (Murine) BRCA2 and CDKN1A Interacting Protein (BCCIP) interaction partners

  1. BCCIP represents a paradoxical class of modulators for tumorigenesis as a suppressor for initiation but a requisite for progression.

  2. BCCIP and its anti-replication stress functions are essential for normal neural development by maintaining an orderly proliferation of neural progenitors.

  3. these data suggest a unique function of BCCIP, not only in repair of DNA damage, but also in resolving stalled replication forks and prevention of replication stress

BCCIP Protein Profile

Protein Summary

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with BCCIP

  • BRCA2 and CDKN1A interacting protein (BCCIP)
  • BRCA2 and CDKN1A interacting protein (bccip)
  • BRCA2 and CDKN1A interacting protein (Bccip)
  • 1110013J05Rik protein
  • BCCIP protein
  • DKFZp459K2416 protein
  • MGC82792 protein
  • MGC89311 protein
  • mp:zf637-1-000774 protein
  • TOK-1 protein
  • TOK1 protein
  • zgc:110272 protein

Protein level used designations for BCCIP

BRCA2 and CDKN1A interacting protein , protein BCCIP homolog , BRCA2 and CDKN1A-interacting protein , bccip-like , BCCIPalpha , BCCIPbeta , BRCA2 and Cip1/p21 interacting protein , TOK-1alpha , TOK-1beta , cdk inhibitor p21 binding protein , p21- and CDK-associated protein 1 , protein TOK-1

GENE ID SPECIES
426225 Gallus gallus
541348 Danio rerio
738638 Pan troglodytes
100173923 Pongo abelii
100528563 Ictalurus punctatus
444344 Xenopus laevis
448392 Xenopus (Silurana) tropicalis
56647 Homo sapiens
66165 Mus musculus
512466 Bos taurus
477864 Canis lupus familiaris
100157478 Sus scrofa
361666 Rattus norvegicus
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