Bestrophin 2 Proteins (BEST2)

BEST2 is a member of the bestrophin gene family of anion channels. Additionally we are shipping Bestrophin 2 Antibodies (54) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BEST2 54831 Q8NFU1
BEST2 212989 Q8BGM5
BEST2 364973  
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Top Bestrophin 2 Proteins at

Showing 3 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days

BEST2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine) ,
Rat (Rattus)

More Proteins for Bestrophin 2 (BEST2) Interaction Partners

Fruit Fly (Drosophila melanogaster) Bestrophin 2 (BEST2) interaction partners

Human Bestrophin 2 (BEST2) interaction partners

  1. BEST2 and BEST4 (show BEST4 Proteins) could be added to the lineage-specific genes of humans intestinal epithelial cells

  2. Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon

  3. These data suggest that Best2 may play a functional role in the regulation of aqueous flow and drainage in humans.

  4. identified three novel VMD2 (show BEST1 Proteins)-related human genes demonstrating a high degree of conservation in their respective RFP (show FPR2 Proteins)-TM domains [VMD2L1, VMD2L2 (show BEST4 Proteins), VMD2L3 (show BEST3 Proteins)]

  5. we examine data obtained from tissue-type and animal models and discuss the current state of bestrophin research, what roles Best2 may play in ocular epithelia and electrophysiology, how perturbation of these functions may result in disease. [REVIEW]

Mouse (Murine) Bestrophin 2 (BEST2) interaction partners

  1. Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon

  2. Best2 plays a role in the generation of IOP by regulating formation of aqueous humor, and inhibition of Best2 function represents an attractive new avenue for regulating IOP in individuals with glaucoma.

  3. Determined HCO3(-)/Cl(-) transport via Best2 and the effect of disease causing mutations.

  4. suggest a role of bestrophin 1 (show BEST1 Proteins) and 2 for Ca(2 (show CA2 Proteins)+) dependent Cl(-) secretion in mouse airways

  5. Asp (show C3 Proteins)-rich domain has two defined binding sites and D301A and D304A mutations may impact the binding of the metal ions

  6. Results suggest that bestrophin 2 plays a critical role during differentiation and growth of axons and cilia.

Bestrophin 2 (BEST2) Protein Profile

Protein Summary

This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 2 gene is mainly expressed in the retinal pigment epithelium and colon.

Gene names and symbols associated with Bestrophin 2 Proteins (BEST2)

  • Bestrophin 2 (Best2)
  • bestrophin 2 (best2-a)
  • bestrophin 2 (Best2)
  • bestrophin 2 (BEST2)
  • bestrophin 2 (best2)
  • bestrophin-2-like (LOC100856525)
  • BEST2 protein
  • CG10173 protein
  • dbest2 protein
  • Dmel\\CG10173 protein
  • GB16861 protein
  • MGC53680 protein
  • MGC75942 protein
  • MGC132361 protein
  • si:dkey-121b10.4 protein
  • Vmd2l1 protein

Protein level used designations for Bestrophin 2 Proteins (BEST2)

bestrophin 2 , CG10173-PA , Best2-PA , vitelliform macular dystrophy 2-like 1 , bestrophin-2-like , VMD2-like gene 1 , bestrophin-2 , vitelliform macular dystrophy 2-like protein 1

38727 Drosophila melanogaster
380009 Xenopus laevis
408898 Apis mellifera
484929 Canis lupus familiaris
567214 Danio rerio
100398099 Callithrix jacchus
100522788 Sus scrofa
394571 Xenopus (Silurana) tropicalis
455751 Pan troglodytes
54831 Homo sapiens
212989 Mus musculus
364973 Rattus norvegicus
529463 Bos taurus
100856525 Canis lupus familiaris
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