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The protein encoded by CD81 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Additionally we are shipping CD81 Antibodies (350) and CD81 Kits (6) and many more products for this protein.
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Molecular cloning; CD81 expression is widely diffused in spleen tissue
adoptive transfer of wild-type regulatory T cells into CD81-deficient mice was sufficient to promote tumor growth and metastasis; these findings suggested that CD81 modulates adaptive and innate immune responses
CD81-Rac (show AKT1 Proteins) interaction exerts an important regulatory role on the innate and adaptive immunity against bacterial infection and suggests a role for CD81 in the development of novel therapeutic targets during infectious diseases.
Plasmodium yoelii sporozoite rhoptry discharge occurs only in the presence of CD81, providing the first direct evidence for a role of CD81 during sporozoite productive invasion.
In vitro myotubes lacking CD9P-1 (show PTGFRN Proteins) or both CD9 (show CD9 Proteins) and CD81 fuse with a higher frequency than normal myotubes
Data suggest that GPC3 (show GPC3 Proteins) down-regulates hepatocyte proliferation by binding to hedgehog (show SHH Proteins) (HH) and down-regulating the HH signaling pathway and binding with CD81, thus making it unavailable to bind to Hhex (show HHEX Proteins) and causing its nuclear translocation.
CD81 interacts with the T cell receptor to suppress signaling.
Data show that effective B cell receptor (BCR (show BCR Proteins)) signaling requires collaboration with the coreceptor CD19 (show CD19 Proteins) organized by the CD81-tetraspanin network.
results indicate that the CD19/CD81 complex interacts with CD38 but this interaction is not required to induce proliferation in mouse B lymphocytes
CD81 promotes the microvillus formation and/or extension while tetraspanin CD82 (show CD82 Proteins) inhibits these events. In addition, CD81 enhances the outward bending of the plasma membrane while CD82 (show CD82 Proteins) inhibits it.
Self-renewing hematopoietic stem cells express CD81 during stress-induced proliferation.
Results suggest that the CD81 antigen (CD81) expressed by B cells has differential effects on B cell proliferation or apoptosis according to Epstein-Barr virus (EBV) infection and the expression level of CD81.
CD81 expression was lower in systemic sclerosis patients compared to controls independent of disease duration.
IFI6 (show IFI6 Proteins) inhibits HCV entry by impairing EGFR (show EGFR Proteins) mediated CD81/CLDN1 (show CLDN1 Proteins) interactions. This may be relevant to other virus entry processes employing EGFR (show EGFR Proteins).
These observations confirm the role of CD81 in liver-stage malaria and question that of scavenger receptor class B member 1 (show SCARB1 Proteins).
Data suggest that the intramolecular 188-196 bond restricts the intrinsic conformational dynamics of D-helix of cluster of differentiation 81 (CD81)-large extracellular loop (LEL), which is essential for hepatitis C virus entry.
LDLR (show LDLR Proteins) was not required for the degradation of CD81 by PCSK9 (show PCSK9 Proteins), but its presence strengthened the PCSK9 (show PCSK9 Proteins) effect.
We propose that CD81 enables the maturation of CD19 (show CD19 Proteins) and its trafficking to the membrane by regulating the exit of CD19 (show CD19 Proteins) from the ER to the pre-Golgi compartment
We demonstrate that this motif plays a role in the maturation and recycling of CD19 (show CD19 Proteins) but in a CD81-independent manner.
These data revealed the crucial role played by His490 and His621 in hepatitis C virus infection, particularly during CD81 binding in cell entry.
findings suggest that homozygous CD81 rs708564 TT may be a genetic modifier for avoiding HCV infection whether as a sole single nucleotide polymorphism or combined with the CLDN1 (show CLDN1 Proteins) rs893051 GG genotype
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies.
, 26 kDa cell surface protein TAPA-1
, target of the antiproliferative antibody 1
, CD81 antigen (target of antiproliferative antibody 1)
, CD 81 antigen