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Carboxylesterase 1 Proteins (CES1)

CES1 encodes a member of the carboxylesterase large family. Additionally we are shipping Carboxylesterase 1 Antibodies (68) and Carboxylesterase 1 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CES1 24346 P10959
CES1 1066 P23141
CES1 12623 Q8VCC2
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Top Carboxylesterase 1 Proteins at

Showing 9 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
HOST_Mammalian Cells Human His tag   50 μg Log in to see 5 Days
HOST_Human Human His tag   10 μg Log in to see 11 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Mouse T7 tag,His tag   100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Rat T7 tag,His tag   100 μg Log in to see 11 to 13 Days
HOST_Human Human Un-conjugated   10 μg Log in to see 11 to 14 Days

CES1 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , , , ,
, ,
Mouse (Murine) ,

More Proteins for Carboxylesterase 1 (CES1) Interaction Partners

Human Carboxylesterase 1 (CES1) interaction partners

  1. some functional CES1 genetic variants (for example, G143E) may impair ACE (show ACE Proteins) inhibitor activation, and consequently affect therapeutic outcomes of ACEI prodrugs.

  2. HNF4alpha (show HNF4A Proteins) regulated CES1 expression by directly binding to the proximal promoter of CES1.

  3. We conclude that the -816A>C variant is not associated with interindividual variability in CES1 expression and activity or therapeutic response to ACEI prodrugs

  4. Our study identified CYP2C19 (show CYP2C19 Proteins)*3 and CES1 rs8192950 as genetic polymorphisms related to recurrent ischemic events in patients with extracranial or intracranial occlusive disease, demonstrating the important roles of CYP2C19 (show CYP2C19 Proteins) and CES1 in patients treated with clopidogrel

  5. Data suggest oseltamivir activation is associated with an SNP in CES1 (rs71647871, G143E); in liver from donors with genotype 143G/E activation is 40% of that from donors with genotype 143G/G. Hepatic CES1 expression in females is 17.3% higher than in males; oseltamivir activation rate in females is 27.8% higher than in males. (Liver tissues used were obtained from tissue banks located in the United States.)

  6. Study confirms previous reports of the CES1P1-CES1 translocation generating the CES1VAR allele with 11 SNPs in the 5'UTR, exon 1, and intron 1 derived from the CES1P1 sequence with decreased CES1 mRNA expression in the human liver by approximately 30% but normal protein expression.

  7. Study found that CYP2C19 (show CYP2C19 Proteins)*2, *3, and *8 were associated with lower odds of the primary and secondary endpoints in the symptomatic intracranial atherosclerotic medical group compared with wild-type homozygotes; due to the low incidence of CES1 genetic variation, our study was unable to demonstrate any association between CES1 variations and the primary and secondary endpoints

  8. decreases of CES and CYP3A4 (show CYP3A4 Proteins) expression and enzymatic activities induced by Fluoxetine are through decreasing PXR (show NR1I2 Proteins) and increasing DEC1 (show BHLHE40 Proteins) in HepG2 cells

  9. The structure and activity of glycosylated and aglycosylated human CES1 has been determined.

  10. CES1 c.428G>A single nucleotide variation increases clopidogrel active metabolite concentrations and antiplatelet effects by reducing clopidogrel hydrolysis to inactive metabolites

Pig (Porcine) Carboxylesterase 1 (CES1) interaction partners

  1. One novel isoform termed alternative pig liver esterase (show ESD Proteins) (APLE) was found to hydrolyze methyl-(2R,4E)-5-chloro-2-isopropyl-4-pentenoate in a highly stereoselective manner (E>200).

  2. The objective of this study is to explore the mechanisms that regulate TGH expression in porcine adipocyte and its role in fasting-induced (show C10orf10 Proteins) and Isoproterenol-stimulated lipolysis in porcine primary adipocytes.

  3. PMPMEase was purified to apparent homogeneity from porcine liver supernatant.

Mouse (Murine) Carboxylesterase 1 (CES1) interaction partners

  1. Hepatic Ces1g/Es-x plays a critical role in limiting hepatic steatosis, very low-density lipoprotein assembly and in augmenting insulin (show INS Proteins) sensitivity.

  2. Data indicate that organic anion-transporting polypeptides Oatp1a/1b-null mice had increased levels of carboxylesterase (Ces) enzymes, which caused higher conversion of irinotecan to SN-38 in plasma, potentially complicating pharmacokinetic analyses.

  3. Hepatic CES1 plays a critical role in regulating both lipid and carbohydrate metabolism and FXR (show NR1H4 Proteins)-controlled lipid homeostasis

Carboxylesterase 1 (CES1) Protein Profile

Protein Summary

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.

Gene names and symbols associated with Carboxylesterase 1 Proteins (CES1)

  • carboxylesterase 1C (Ces1c)
  • carboxylesterase 1 (CES1)
  • liver carboxylesterase 1 (CpipJ_CPIJ013026)
  • liver carboxylesterase 1 (CpipJ_CPIJ016339)
  • liver carboxylesterase (LOC100009551)
  • carboxylesterase 1-like (LOC508916)
  • carboxylesterase 1A (Ces1a)
  • carboxylesterase 1E (Ces1e)
  • carboxylesterase 1G (Ces1g)
  • ACAT protein
  • APLE protein
  • CE-1 protein
  • CEH protein
  • Ces-1 protein
  • CES-K1 protein
  • Ces1 protein
  • CES2 protein
  • CESDD1 protein
  • Es1 protein
  • Es2 protein
  • Es22 protein
  • hCE-1 protein
  • HMSE protein
  • HMSE1 protein
  • PCE-1 protein
  • PMPMEase protein
  • REH protein
  • Ses-1 protein
  • SES1 protein
  • TGH protein

Protein level used designations for Carboxylesterase 1 Proteins (CES1)

esterase 1 , E1 , REH , NREH , ES-THET , esterase-2 , carboxyesterase ES-1 , retinyl ester hydrolase , liver carboxylesterase 1 , neutral retinyl ester hydrolase , Esterase 2 member of carboxylesterase-cluster 1 , esterase 2, member of carboxylesterase-cluster 1 , carboxylesterase 1 , carboxylesterase 1 (monocyte/macrophage serine esterase 1) , acyl coenzyme A:cholesterol acyltransferase , acyl-coenzyme A:cholesterol acyltransferase , brain carboxylesterase hBr1 , carboxylesterase 2 (liver) , cholesteryl ester hydrolase , cocaine carboxylesterase , egasyn , human monocyte/macrophage serine esterase 1 , methylumbelliferyl-acetate deacetylase 1 , monocyte/macrophage serine esterase , serine esterase 1 , triacylglycerol hydrolase , carboxylesterase D1 , alternative pig liver esterase , liver carboxylesterase , prenylated methylated protein methyl esterase , proline-beta-naphthylamidase , carboxylesterase 1-like , ES-HTEL , carboxyesterase ES-3 , esterase 22 , liver carboxylesterase 3 , pI 5.5 esterase , ES-x

24346 Rattus norvegicus
454097 Pan troglodytes
493774 Felis catus
699486 Macaca mulatta
6045866 Culex quinquefasciatus
6050034 Culex quinquefasciatus
100009551 Oryctolagus cuniculus
100144615 Monodelphis domestica
1066 Homo sapiens
403643 Canis lupus familiaris
397478 Sus scrofa
508916 Bos taurus
679817 Rattus norvegicus
29225 Rattus norvegicus
12623 Mus musculus
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