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Three different forms of human pancreatic procarboxypeptidase A have been isolated. Additionally we are shipping Carboxypeptidase A3 (Mast Cell) Kits (26) and Carboxypeptidase A3 (Mast Cell) Proteins (8) and many more products for this protein.
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Human Polyclonal CPA3 Primary Antibody for EIA, IHC (p) - ABIN951032
Pejler, Knight, Henningsson, Wernersson: Novel insights into the biological function of mast cell carboxypeptidase A. in Trends in immunology 2009
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Carboxypeptidase A3 was differentially expressed between Fibromyalgia patients and healthy controls.
Urine CPA3 was increased in patients with chronic prostatitis/chronic pelvic pain syndrome compared to controls.
The crystal structure of the human CPA4 carboxypeptidase in complex with SmCI, a peptide protease inhibitor.
NvCL form Nerita versicolor is a tight-binding inhibitor that interacts with the active site of the CPA4 (show CPA4 Antibodies) in a substrate-like manner.
CPA4 (show CPA4 Antibodies) gene is imprinted, with preferential expression from the maternal allele in many fetal tissues, but not in fetal brain.
CPA4 functions in neuropeptide processing and regulation in the extracellular environment
The cDNA encoding human colon mast cell carboxypeptidase can be successfully cloned and expressed in E. coli and P. pastoris.
The three-dimensional structure of procarboxypeptidase-A4 (hPCPA4) has been solved and shows the features of related metallocarboxypeptidase zymogens, with a preformed alpha/beta/-hydrolase active-enzyme moiety (hCPA4) and an inhibiting pro-domain (PD).
Data suggest that carboxypeptidase A3 (Cpa3)-Cre; myeloid cell leukemia sequence 1 (Mcl-1)(fl/fl (show FLT3LG Antibodies)) mice may be useful in analyzing the roles of mast cells and basophils in health and disease.
mast cell chymase (show CMA1 Antibodies) and CPA (show CPA1 Antibodies) have key roles in both the generation and degradation of Ang II (show AGT Antibodies)
cathepsin E (show CTSE Antibodies) is located in mast-cell secretory granules in complex with heparin proteoglycans, and has a role in the processing of procarboxypeptidase A into active protease
Mc-cpa plays a crucial role for the generation of phenotypically mature mast cells.
This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness.
mast cell carboxypeptidase A
, tissue carboxypeptidase A
, carboxypeptidase A3