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CARD14 encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Additionally we are shipping CARD14 Proteins (6) and many more products for this protein.
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Human Polyclonal CARD14 Primary Antibody for EIA, IHC (p) - ABIN1449966
Fanning, Anderson: Protein modules as organizers of membrane structure. in Current opinion in cell biology 1999
Show all 4 references for ABIN1449966
Human Polyclonal CARD14 Primary Antibody for WB - ABIN528893
Huh, Kim, Kim, Song, Jung, Jeong, Lee, Kim, Lee, An: Dysregulation of miR-106a and miR-591 confers paclitaxel resistance to ovarian cancer. in British journal of cancer 2013
The results indicate that the common CARD14 p.Arg820Trp variant might have a significant effect on the response to anti-TNF (show TNF Antibodies) therapies among patients with psoriasis. In addition, rare CARD14 missense variants could also predispose to a better response.
Our findings, combined with the published literature, suggest that Pityriasis Rubra Pilaris Type V, both familial and sporadic, can be caused by CARD14 mutations.
Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10 (show BCL10 Antibodies)-MALT1 (show MALT1 Antibodies)-dependent NF-kappaB (show NFKB1 Antibodies) activation
genetic evidence suggests association of the CARD14 single nucleotide polymorphism rs11652075 and other rare mutations in this gene with psoriasis. To assess whether combined data support the relationship between CARD14 rs11652075 and susceptibility to this disease, we conducted a meta-analysis. Our results demonstrate a significant association between the CARD14 rs11652075 polymorphism and psoriasis.
The authors observations provide further insights into the genetics of psoriasis and functional information on novel CARD14 mutational variants seen in cases from Tunisia and other populations.
Genetic interactions of SNPs in CARD14, SENP1 (show SENP1 Antibodies) and VEGFA (show VEGFA Antibodies) might represent a functional mechanism in the pathogenesis of high altitude polycythemia.
analysis of 105 individuals with generalized pustular psoriasis (GPP) identified a low-frequency variant (p.Asp176His) that causes constitutive CARD14 oligomerization
CARD14 protein missense mutation found in patients diagnosed with psoriasis.
no definite causative genetic mutation in CARD14 as identified in familial pityriasis rubra pilaris after screening 8 non-familial patients of type I, type III and type IV pityriasis rubra pilaris
The study identified the DEP (show ZDHHC21 Antibodies) domain-containing protein DEPDC7 as cellular binding partner of CARMA2 and CARMA3 (show CARD10 Antibodies) proteins.
This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants.
CARD-containing MAGUK protein 2
, bcl10-interacting maguk protein 2
, card-maguk protein 2
, carma 2
, caspase recruitment domain-containing protein 14
, bcl10-interacting MAGUK protein 2