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CDC25B is a member of the CDC25 family of phosphatases. antibodies-online currently ships Cell Division Cycle 25 Homolog B (S. Pombe) (CDC25B) Antibodies (155), and to destinations worldwide.
Show Cell Division Cycle 25 Homolog B (S. Pombe) (CDC25B) Antigene Profile
Showing 6 out of 9 Cell Division Cycle 25 Homolog B (S. Pombe) (CDC25B) ELISA Kits
Indirubin, an acting component of indigo naturalis, inhibits EGFR activation and EGF-induced CDC25B gene expression in epidermal ke
downregulation of Cdc25B resulted in slower growth, more G2/M cells, weaker capacity for migration and invasion and induction of apoptosis in renal carcinoma cell line 769-P transfectants; findings suggest an important role of Cdc25B in renal cell carcinoma development
Transcriptional repression mediated by IER5 regulates Cdc25B expression levels via the release of NF-YB and p300 (show EP300 ELISA Kits) in acute myeloid leukemia.
We identified CDC25B as novel miR-148a target which may confer a proliferative advantage in pancreatic ductal adenocarcinomas.
Ser169 phosphorylation can disrupt 14-3-3 binding to Ser151 activating Cdc25B3, providing a mechanism for regulating Cdc25B3 activation without dephosphorylation of the 14-3-3 binding sites.
there are 13 sites phosphorylated by PLK1 in CDC25B.This study illustrates the complexity of the phosphorylation pattern and of the subsequent regulation of CDC25B activity.
Deletion and mutation analyses of the Cdc25B promoter revealed that downregulation by p53 is dependent on the presence of functional Sp1/Sp3 and NF-Y binding sites
CDC25B forms a close association with Ctn-2 proteins at the centrosome.
Our findings reveal the existence of a previously unrecognized CDC25B isoform that operates specifically in the nucleus to reinitiate G2/M transition after DNA damage
Cdc14A phosphatase prevents premature activation of Cdk1 regulating Cdc25A and Cdc25B at the entry into mitosis.
Ser321 of Cdc25B is the specific binding site for 14-3-3epsilon binding.
Protein kinase A the early development of mouse embryos by phosphorylation of S149 and S321 of CDC25B, which plays an important role in the regulation of G(2)/M transition in the mitotic cell cycle of fertilized mouse eggs.
In the DNA damage response, instead of inhibiting cyclin B-CDK1 through destruction of Cdc25A phosphatase, oocytes utilize an inhibitory phosphorylation of Cdc25B.
Cdc25B overexpression in early mouse two-cell embryos reverses two-cell block and promotes their development into four-cell stage by activating MPF.
MCPH1, through its function in the Chk1-Cdc25-Cdk1 pathway to couple the centrosome cycle with mitosis, is required for precise mitotic spindle orientation and thereby regulates the progenitor division mode to maintain brain size.
CDC25A and CDC25B but not CDC25C compensate for each other to maintain the proliferative capacity of intestinal epithelial stem and progenitor cells
Ser(149) may be another potential PKA phosphorylation target of Cdc25B in G(2)/M transition of fertilized mouse eggs and Cdc25B as a direct downstream substrate of PKA in mammals
Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation
Cdc25A, or possibly other phosphatases, is able to functionally compensate for the loss of Cdc25B and Cdc25C in mice
Shh contributes to CDC25B transcriptional activation in the neural tube both of chick and mouse embryos
cell division cycle 25 homolog B (S. pombe) (CDC25B)
, cell division cycle 25B (CDC25B)
, cell division cycle 25B (Cdc25b)
, cell division cycle 25B (cdc25b)
M-phase inducer phosphatase 2
, dual specificity phosphatase Cdc25B
, cell division cycle 25 homolog B
, cell division cycle 25 homolog B (S. pombe)
, M-phase inducer phosphatase 2-like
, m-phase inducer phosphatase 2-like
, cell division cycle 25B
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.