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Chemokine (C-C Motif) Ligand 2 Proteins (CCL2)

CCL2 is one of several cytokine genes clustered on the q-arm of chromosome 17. Additionally we are shipping Chemokine (C-C Motif) Ligand 2 Antibodies (528) and Chemokine (C-C Motif) Ligand 2 Kits (167) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CCL2 24770 P14844
CCL2 6347 P13500
CCL2 20296 P10148
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Top Chemokine (C-C Motif) Ligand 2 Proteins at

Showing 10 out of 130 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   50 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Mouse His tag Chemokine (C-C Motif) Ligand 2 (CCL2) (AA 24-96), (partial) protein (His tag) 50 μg Log in to see 9 to 11 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 5 to 6 Days
HOST_Escherichia coli (E. coli) Rat Un-conjugated   5 μg Log in to see 5 to 6 Days
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   5 μg Log in to see 5 to 6 Days
HOST_Escherichia coli (E. coli) Rat Un-conjugated 100 μg Log in to see 4 to 6 Days
HOST_Escherichia coli (E. coli) Mouse Un-conjugated 100 μg Log in to see 4 to 6 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days

CCL2 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus) , ,

Human , , ,
Mouse (Murine) , , , ,

Top referenced Chemokine (C-C Motif) Ligand 2 Proteins

  1. Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305100 : Ernst, Zhang, Hancock, Rutledge, Corless, Rollins: Biochemical and biologic characterization of murine monocyte chemoattractant protein-1. Identification of two functional domains. in Journal of immunology (Baltimore, Md. : 1950) 1994 (PubMed)
    Show all 5 references for ABIN1305100

  2. Rat (Rattus) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305099 : Capsoni, Minonzio, Ongari, Zanussi: A new simplified single-filter assay for 'in vitro' evaluation of chemotaxis of 51Cr-labeled polymorphonuclear leukocytes. in Journal of immunological methods 1989 (PubMed)
    Show all 5 references for ABIN1305099

  3. Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1046668 : Rollins, Morrison, Stiles: Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties. in Proceedings of the National Academy of Sciences of the United States of America 1988 (PubMed)
    Show all 3 references for ABIN1046668

  4. Human CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305101 : Rollins, Stier, Ernst, Wong: The human homolog of the JE gene encodes a monocyte secretory protein. in Molecular and cellular biology 1990 (PubMed)
    Show all 2 references for ABIN1305101

  5. Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN413564 : Zhu, Daghini, Chade, Rodriguez-Porcel, Napoli, Lerman, Lerman: Role of oxidative stress in remodeling of the myocardial microcirculation in hypertension. in Arteriosclerosis, thrombosis, and vascular biology 2006 (PubMed)

  6. Human CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN413594 : Gray, Di Marco, Okabe, Szyndralewiez, Heitz, Montezano, de Haan, Koulis, El-Osta, Andrews, Chin-Dusting, Touyz, Wingler, Cooper, Schmidt, Jandeleit-Dahm: NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. in Circulation 2013 (PubMed)

More Proteins for Chemokine (C-C Motif) Ligand 2 (CCL2) Interaction Partners

Human Chemokine (C-C Motif) Ligand 2 (CCL2) interaction partners

  1. immunosensor allowed the rapid detection of MCP-1 in buffer and spiked human serum samples. An almost 2 order of magnitude linear range was observed, between 84.3 and 1582.1pg/mL and the limits of blank and detection were determined to be 0.3 and 0.5pg/mL, respectively

  2. Results indicate that urinary MCP-1 was associated with blood pressure elevation in this population of obese young adults.

  3. our data confirmed the relevance of the MCP1 gene as a risk locus to Pott's disease in a trans-populational manner.

  4. genetic association study in population in China: Data suggest higher frequency of GG genotype/G allele in -2518 SNP in MCP1 is observed in diabetes type 2 (DT2) with proliferative/non-proliferative retinopathies as compared with DT2 without retinopathy.

  5. the MCP1-induced cortactin (show CTTN Proteins) phosphorylation is dependent on PLCbeta3-mediated PKCdelta (show PKCd Proteins) activation, and siRNA-mediated down-regulation of either of these molecules prevents cortactin (show CTTN Proteins) interaction with WAVE2 (show WASF2 Proteins)

  6. MCP-1-2518 A/G polymorphism is associated with increased risk to breast cancer.

  7. Data show that monocytes from elderly denture wearers with Candida-related denture stomatitis produced lower levels of proinflammatory cytokines CXCL-8 (show IL8 Proteins), IL-6 (show IL6 Proteins) and MCP-1.

  8. CCL2 downregulation in South Asians may be an attempt to protect muscle against macrophage infiltration, and defects in fatty acid partitioning to muscle may lead to the disproportionate adiposity and adverse cardiometabolic profile in South Asians.

  9. R/R genotype of FCGR2A (show FCGR2A Proteins) p.R131H and G/G genotype of CCL2 c.-2518 A > G polymorphisms are associated with thrombocytopenia, which is a characteristic laboratory finding in dengue infections.

  10. Together, these findings suggest that CCL2, RARRES2 (show RARRES2 Proteins) and EFNB2 (show EFNB2 Proteins) are host cell factors involved in respiratory syncytial virus replication.

Mouse (Murine) Chemokine (C-C Motif) Ligand 2 (CCL2) interaction partners

  1. FAMP significantly preserved cytochrome C (show CYCS Proteins) in the mitochondrial fraction and inhibited its release into the cytosolic fraction in the heart, but did not significantly reduce mRNA levels of monocyte chemoattractant protein-1

  2. Mycobacterium chelonae activates the gene expressions of chemokine (C-C motif) ligand 2 (CCL2) and CCL5 (show CCL5 Proteins) in murine bone marrow-derived macrophages and in vivo mouse model.

  3. This study demonstrated that Chemokine (show CCL1 Proteins) CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation.

  4. cl2 (show DCLK2 Proteins) mRNAs increased within 5 h after injury in mouse cortical slices.

  5. Data show that cathepsins S (CatS) regulates CCL2 chemokine (show CCL1 Proteins) expression by modulation of CD74 (show CD74 Proteins) antigen processing.

  6. Data show that monocyte chemotactic protein 1 (MCP-1) expressed by HEK293T cells could apparently increase the migration of macrophages.

  7. Data indicate that Zoledronic acid (ZA) decreased mesenchymal stem cells (MSC (show MSC Proteins))-monocyte chemotactic protein 1 (MCP-1) and therefore reduced the recruitment of tumor-associated macrophages (TAMs) to the tumor sites and hence inhibited the tumor growth.

  8. activation of canonical Wnt (show WNT2 Proteins) signaling might contribute to the focal retinal degeneration of mouse models with Ccl2 and Cx3cr1 (show CX3CR1 Proteins) deficiency

  9. Genetically modified mice overexpressing a human PS1 (show PSEN1 Proteins) familial Alzheimer's disease mutant on a CCL2 null background significantly decreased hippocampal neurogenesis and affected age-dependent learning and memory.

  10. Given the important role of the TAM (show CCNA1 Proteins) phenotype in the tumor microenvironment, inhibitory effect of luteolin on the monocyte recruitment and cancer migration via suppression of the TAM (show CCNA1 Proteins)-secreted CCL2 suggests a novel therapeutic approach to treat tumors.

Cow (Bovine) Chemokine (C-C Motif) Ligand 2 (CCL2) interaction partners

  1. resence of type 2 diabetes negatively affects the work of cytokines and markers of fibrosis, as evidenced by higher levels of interleukin-1beta and monocyte chemoattractant protein-1, compared with patients without diabetes

  2. Studied SNPs in the bovine toll-like receptor 4 (TLR4 (show TLR4 Proteins)) and monocyte chemo attractant protein-1(CCL2) genes.

  3. The LEP (show LEP Proteins), IGF2 and CCL2 genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.

  4. immune cells and endothelial cells can interact cooperatively to increase CCL2 secretion in the corpus luteum

Rabbit Chemokine (C-C Motif) Ligand 2 (CCL2) interaction partners

  1. Data show that peripheral blood endothelial progenitor cells can increase the expressions of chemokines CCL2 and CXCL12 (show CXCL12 Proteins) and promote the migration of enhanced green fluorescent protein-positive bone marrow stromal cells to bone defect site.

  2. In a cerebral aneurysm, expression of MCP1 peaked after induction for one week, then decreased. MCP1 induced macrophage adhesion and infiltration in the artery wall of aneurysms, and contributed to the occurrence and development of brain aneurysm.

  3. Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8 (show IL8 Proteins)) decreased significantly in Dachengqi decoction treatment group.

  4. measurements of CCL2 and macrophages can serve as new inflammatory biomarkers to evaluate the safety of promising novel microbicides for prevention of HIV.

  5. Expression of MCP-1 was successfully inhibited by transfecting MCP-1 siRNA expression plasmid to the carotid artery, and the progression of atherosclerosis was restricted by RNAi-mediated silencing of MCP-1 expression.

Pig (Porcine) Chemokine (C-C Motif) Ligand 2 (CCL2) interaction partners

  1. CXCL10 (show CXCL10 Proteins) protein was detected in serum from pigs infected with a high virulence African swine fever virus isolate. Levels of CCL2 mRNA were increased in pigs infected with the high virulence isolate compared to a low virulence isolate.

  2. Porcine CCL2 binding on Tuk4+SLA (show SLA Proteins)-II- but not on Tuk4-SLA (show SLA Proteins)-II+ cells was detected by using a CCL2-green fluorescence protein fusion protein.

  3. The protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling.

  4. MCP-1 contributes to functional and structural impairment in the kidney in renal artery stenosis, mainly in the tubulointerstitial compartment

  5. Contrast media did not affect bone marrow cell viability/MCP-1 secretion.

  6. Porcine vessel wall injury via balloon arthroplasty upregulates expression of CCL2 by coronary artery transmural and perivascular cells in a sequential pattern.

  7. in the aortic arch expression of monocyte chemoattractant protein 1 (MCP-1) was upregulated, compared with the thoracic aorta

  8. Variable gene expression (eg, matrix metalloproteinase-9 (show MMP9 Proteins), CCL2 and Lp-PLA(2 (show Lp-PLA2 Proteins)) mRNAs), both in regard to the arterial bed and duration of disease, was associated with variable plaque development and progression.

  9. myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor (show F3 Proteins) cyclo-oxygenase-2, monocyte chemoattractant protein-1 and CRP (show CRP Proteins)

Chemokine (C-C Motif) Ligand 2 (CCL2) Protein Profile

Protein Summary

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

Gene names and symbols associated with CCL2

  • chemokine (C-C motif) ligand 2 (CCL2)
  • chemokine (C-C motif) ligand 2 (Ccl2)
  • macrophage cationic peptide 1 (MCP-1)
  • mast cell proteinase-1 (MCP1)
  • AI323594 protein
  • GDCF-2 protein
  • HC11 protein
  • HSMCR30 protein
  • JE protein
  • MCAF protein
  • MCP-1 protein
  • MCP-1A protein
  • MCP1 protein
  • MCP1A protein
  • SCYA2 protein
  • Sigje protein
  • SMC-CF protein

Protein level used designations for CCL2

small inducible cytokine A2 , C-C motif chemokine 2 , immediate-early serum-responsive JE protein , immediate-early serum-responsive protein JE , monocyte chemoattractant protein 1 , monocyte chemoattractant protein-1 , monocyte chemotactic protein 1 , small inducible gene JE , small-inducible cytokine A2 , monocyte chemotactic and activating factor , monocyte secretory protein JE , small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je) , small inducible cytokine subfamily A (Cys-Cys), member 2 , platelet-derived growth factor-inducible protein JE , acidic seminal fluid protein , monocyte chemotactic protein 1A , MCP-1 , chemokine CCL2/MCP-1 , CS-III , NP-1 , antiadrenocorticotropin peptide III , corticostatin III , corticostatin-3 , macrophage antibiotic peptide MCP-1 , SMCP-1A , mast cell protease 1A

748205 Pan troglodytes
24770 Rattus norvegicus
6347 Homo sapiens
20296 Mus musculus
281043 Bos taurus
100009130 Oryctolagus cuniculus
397422 Sus scrofa
403981 Canis lupus familiaris
100135494 Cavia porcellus
100034136 Equus caballus
100172740 Pongo abelii
101120093 Ovis aries
574138 Macaca mulatta
100009115 Oryctolagus cuniculus
443546 Ovis aries
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