Choline Kinase alpha Proteins (CHKA)

The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. Additionally we are shipping Choline Kinase alpha Antibodies (56) and Choline Kinase alpha Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CHKA 1119 P35790
CHKA 12660 O54804
Rat CHKA CHKA 29194 Q01134
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Top Choline Kinase alpha Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
$785.40
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_Escherichia coli (E. coli) Protozoa Un-conjugated   100 μg Log in to see 11 to 12 Days
$759.36
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HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 12 Days
$1,149.12
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CHKA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for Choline Kinase alpha (CHKA) Interaction Partners

Human Choline Kinase alpha (CHKA) interaction partners

  1. We found levels of CHKA to be increased in human HCCs (show HCCS Proteins) compared to nontumor tissues, and increased expression to be associated with tumor aggressiveness. Overexpression of CHKA in HCC (show FAM126A Proteins) cell lines increased their invasiveness, resistance to EGFR (show EGFR Proteins) inhibitors, and ability to form metastatic tumors in mice by promoting interaction of EGFR (show EGFR Proteins) with mechanistic target of rapamycin (show FRAP1 Proteins) complex 2.

  2. Study shows increased CHKA expression in pancreatic ductal adenocarcinoma tumors and may be a predictive marker of response to chemotherapy.

  3. These data also support the approach of antitumor strategies that destabilize Chk-alpha protein or downregulate PtdCho in breast cancer treatment.

  4. Downregulation of choline kinase-alpha enhances autophagy in tamoxifen-resistant breast cancer cells.

  5. CHKA can act as an AR chaperone, providing, to our knowledge, the first evidence for kinases as molecular chaperones, making CHKA both a marker of tumor progression and a potential therapeutic target for PCa (show FLVCR1 Proteins).

  6. Identify choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma.

  7. choline kinase alpha is inhibited by a near-infrared fluorescent carbocyanine

  8. Increased expression of CHKA is seen in malignant lesions of prostate cancer

  9. Chokalpha possessed oncogenic activity and could be a potential therapeutic target in T-cell lymphoma , as well as other hematological malignancies with interrupted Ras signaling pathways

  10. Downregulation of Chk-alpha with siRNA increased PLD1 expression, and downregulation of PLD1 increased Chk-alpha expression.

Mouse (Murine) Choline Kinase alpha (CHKA) interaction partners

  1. hepatic phosphatidylcholine (show SGMS2 Proteins) is regulated by the circadian clock through a Bmal1 (show ARNTL Proteins)-Rev-erbalpha (show NR1D1 Proteins)-Chkalpha axis

  2. Enforced expression of either CK(alpha) or CCTalpha (show PCYT1A Proteins) increased the rate of synthesis and the amount of PtdCho, and these cells initiated neuronal differentiation.

  3. Lack of muscle degeneration in forelimbs of Chkb (show CHKB Proteins)(-/-) mice is due to abundant choline kinase alpha and the stable homeostasis of phosphatidylcholine (show SGMS2 Proteins).

  4. Experimental evidence for the presence of heteromeric ChoK/EtnK in any source. The activity of ChoK/EtnK in the cell is controlled not only by the level of each isoform but also by their combination to form the active oligomer complex.

  5. ChoK may have a role in carcinogenesis

  6. Data suggest that the choline kinase alpha promoter has a distal element (-875/-867) that binds c-jun (show JUN Proteins) and the binding of c-jun (show JUN Proteins) is enhanced by treatment with CCl4 (show CCL4 Proteins).

  7. Chka is an essential gene for early embryonic development, but adult mice do not require full expression of the gene for normal levels of phosphatidylcholine (show SGMS2 Proteins).

Choline Kinase alpha (CHKA) Protein Profile

Protein Summary

The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Choline Kinase alpha Proteins (CHKA)

  • choline kinase alpha (chka)
  • choline kinase alpha (CHKA)
  • choline kinase alpha (MCYG_00090)
  • choline kinase (PF14_0020)
  • choline kinase 1 (CK1)
  • choline kinase (CNI01400)
  • choline kinase alpha (Chka)
  • ATCK1 protein
  • Chetk-alpha protein
  • Chk protein
  • CHKA protein
  • chkb protein
  • ChoK protein
  • CHOLINE KINASE protein
  • choline kinase 1 protein
  • CK protein
  • CK-R protein
  • CK/EK-alpha protein
  • CKI protein
  • EK protein
  • EtnK-alpha protein
  • F14O23.8 protein
  • F14O23_8 protein
  • im:7143625 protein
  • si:dkey-12e7.3 protein
  • wu:fd46h01 protein

Protein level used designations for Choline Kinase alpha Proteins (CHKA)

choline kinase alpha , choline kinase beta , choline kinase , CHETK-alpha , ethanolamine kinase , choline/ethanolamine kinase alpha , CK , EK , choline kinase R

GENE ID SPECIES
558499 Danio rerio
476002 Canis lupus familiaris
514865 Bos taurus
451376 Pan troglodytes
496957 Xenopus (Silurana) tropicalis
9223440 Arthroderma otae CBS 113480
811591 Plasmodium falciparum 3D7
843500 Arabidopsis thaliana
3259492 Cryptococcus neoformans var. neoformans JEC21
100013074 Monodelphis domestica
100059839 Equus caballus
100566078 Anolis carolinensis
100587988 Nomascus leucogenys
423112 Gallus gallus
1119 Homo sapiens
12660 Mus musculus
29194 Rattus norvegicus
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