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Collagen, Type I, alpha 2 Proteins (COL1A2)

COL1A2 encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Additionally we are shipping Collagen, Type I, alpha 2 Antibodies (75) and Collagen, Type I, alpha 2 Kits (60) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COL1A2 1278 P08123
COL1A2 12843 Q01149
Rat COL1A2 COL1A2 84352 P02466
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Top Collagen, Type I, alpha 2 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days

COL1A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Collagen, Type I, alpha 2 (COL1A2) Interaction Partners

Human Collagen, Type I, alpha 2 (COL1A2) interaction partners

  1. COL1A2 mutation is associated with atypical osteogenesis imperfect.

  2. analysis of COL1A2 (type I collagen) polymorphisms in the central-eastern Mediterranean Basin

  3. Two gross deletions have been found in the genes coding for collagen type I in the Chinese osteogenesis imperfecta population, and the deletion of exons 17 to 23 in the COL1A2 gene is a novel mutation.

  4. Using TCGA analysis, COL1A1 (show COL1A1 Proteins) and COL1A2 were found to be up-regulated, which could provide a molecular explanation for the development of blastic metastases.

  5. Collagen I mutation analysis(COL1A1 (show COL1A1 Proteins) and COL1A2 ) was performed in the family of 97% of known cases, with causative mutations found in 87%. Qualitative mutations caused 32% of Osteogenesis imperfecta type I.

  6. Severe osteogenesis imperfecta caused by double glycine substitutions near the amino-terminal triple helical region in COL1A2.

  7. Data indicate that LA motif protein LARP6 binding to spliced leader RNA (5'SL) of collagen alpha2(I) mRNA is more stable than the binding to 5'SL of alpha1(I) mRNA.

  8. These data indicate a novel functional role of AnxA2 (show ANXA2 Proteins) in the negative post-transcriptional regulation of type I collagen synthesis in human fibroblasts.

  9. The novel c.946G>T/p.G316C mutation in COL1A2 gene is associated with with osteogenesis imperfecta type I.

  10. This study revealed that Notch (show NOTCH1 Proteins) signaling-related molecules (including Notch1 (show NOTCH1 Proteins), Hes1, and others) are expressed in L929 and MRC-5 cells and that Notch (show NOTCH1 Proteins) signaling regulates the expression of col1alpha1 and col1alpha2 in both cell lines.

Cow (Bovine) Collagen, Type I, alpha 2 (COL1A2) interaction partners

  1. In advanced stage granulomas in Mycobacterium bovis-infected cattle, there was an increase in the expression of type I procollagen

  2. Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.

Mouse (Murine) Collagen, Type I, alpha 2 (COL1A2) interaction partners

  1. Resveratrol effectively inhibits collagen I synthesis in IGF-1 (show IGF1 Proteins)-stimulated colonic fibroblasts, partly by inhibiting IGF-1R (show IGF1R Proteins) activation, and SIRT1 (show SIRT1 Proteins) is also responsible for the process.

  2. Sp7/Osterix (show SP7 Proteins) induces the mouse Col1a2 expression via the proximal promoter in osteoblastic cells in association with osteoblast differentiation.

  3. Down-regulation let-7 by transforming growth factor-beta1-induced Lin28 (show LIN28A Proteins) upregulates collagen expression in glomerular mesangial cells from diabetic mice.

  4. Data indicate serine-threonine kinase receptor-associated protein (show STRAP Proteins) (STRAP) as a novel regulator of the coordinated translation of collagen alpha1(I) and alpha2(I) mRNAs.

  5. The data showed that the Smad (show SMAD1 Proteins) pathway mediated the expression of type I collagen in radiation induced fibrosis.

  6. MRTF-A is an important regulator of collagen synthesis in lung fibroblasts and exhibits a dependence on both SRF and Sp1 (show SP1 Proteins) function to enhance collagen expression

  7. study reports that vimentin (show VIM Proteins) filaments associate with collagen mRNAs in a 5'stem-loop sequence and LARP6 (show LARP6 Proteins)-dependent manner and stabilize collagen mRNAs

  8. Muscle weakness in +/oim and oim/oim mice (frameshift mutation in the COL1A2 gene)reflects inherent skeletal muscle pathology.

  9. post-transcriptional regulation of Tsc-22 (show TSC22D1 Proteins) mediated through Ybx1 (show YBX1 Proteins), a miR (show MLXIP Proteins)-216a target, plays a key role in TGF-beta (show TGFB1 Proteins)-induced Col1a2 in MC related to the pathogenesis of diabetic nephropathy

  10. These findings reveal a novel function of Fra-2 (show FOSL2 Proteins)/AP-1 (show JUN Proteins) as a positive regulator of bone and matrix formation in mice and humans.

Pig (Porcine) Collagen, Type I, alpha 2 (COL1A2) interaction partners

Collagen, Type I, alpha 2 (COL1A2) Protein Profile

Protein Summary

This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Gene names and symbols associated with COL1A2

  • collagen type I alpha 2 (LOC100860940)
  • collagen, type 1, alpha 2 (col1a2)
  • collagen, type I, alpha 2 (COL1A2)
  • collagen, type I, alpha 2 (Col1a2)
  • collagen, type I, alpha 2 (col1a2)
  • AA960264 protein
  • AI325291 protein
  • alpha2(I) protein
  • Col1a-2 protein
  • Cola-2 protein
  • Cola2 protein
  • hm:zehn2357 protein
  • OI4 protein
  • oim protein
  • wu:fa98d05 protein
  • wu:fa99g10 protein
  • wu:fb04c08 protein
  • wu:fb11d06 protein
  • zehn2357 protein

Protein level used designations for COL1A2

procollagen, type I, alpha 2 , alpha 2(I) collagen , alpha-2 type I collagen , alpha-2(1) collagen , collagen alpha 2(I) chain , collagen alpha-2(I) chain , alpha 2(I)-collagen , collagen I, alpha-2 polypeptide , collagen of skin, tendon and bone, alpha-2 chain , type I procollagen , COL1A2 gene exons 8 through 12 , type I procollagen pro-alpha 2 chain , alpha 2(I) procollagen , collagen I alpha-2 polypeptide , collagen COL1A2 , osteogenesis imperfecta , alpha 2 type I collagen , collagen a2(I)

100860940 Capra hircus
380419 Xenopus laevis
396243 Gallus gallus
1278 Homo sapiens
403824 Canis lupus familiaris
282188 Bos taurus
100008997 Oryctolagus cuniculus
12843 Mus musculus
84352 Rattus norvegicus
100719158 Cavia porcellus
100626716 Sus scrofa
336471 Danio rerio
100135811 Oncorhynchus mykiss
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