Collagen, Type VI, alpha 3 Proteins (COL6a3)

COL6a3 encodes the alpha-3 chain, one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. Additionally we are shipping COL6a3 Antibodies (17) and COL6a3 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COL6a3 12835  
Rat COL6a3 COL6a3 367313  
COL6a3 1293 P12111
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Top COL6a3 Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
HOST_Human Cells Human Un-conjugated 100 μg Log in to see 20 to 21 Days
HOST_Escherichia coli (E. coli) Mouse T7 tag,His tag   100 μg Log in to see 15 to 18 Days

COL6a3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

More Proteins for Collagen, Type VI, alpha 3 (COL6a3) Interaction Partners

Mouse (Murine) Collagen, Type VI, alpha 3 (COL6a3) interaction partners

  1. Data show that the TFIID subunit (show TAF6 Proteins) TAF4 (show TAF4 Proteins) is essential to restrain the growth promoting properties of collagen 6A3 (Col6a3).

  2. mice lacking normal alpha3(VI) collagen chains display mild musculoskeletal phenotypes similar to mice deficient in the alpha1(VI) collagen alpha chain (show FCGRT Proteins), suggesting that alpha3(VI) collagen does not elicit essential functions in normal growth and development

Human Collagen, Type VI, alpha 3 (COL6a3) interaction partners

  1. Patients with chronic kidney disease (CKD) are at increased risk of end-stage renal disease (ESRD) and early mortality. Serum endotrophin, a COL6A3 cleavage product was significantly associated with progression to ESRD.

  2. In conjunction with the relatively high frequency of homozygous carriers of reported mutations in publically available databases, our data call a causal role for variants in COL6A3 in isolated dystonia into question.

  3. Data indicate that circulating plasma COL6A3 in colorectal cancer (CRC (show CALR Proteins)) patients was upregulated significantly comparing with healthy peoples.

  4. Parental mosaicism was confirmed in the four families through quantitative analysis of the ratio of mutant versus wild-type allele (COL6A1 (show COL6A1 Proteins), COL6A2 (show COL6A2 Proteins), and COL6A3) in genomic DNA from various tissues; consistent with somatic mosaicism, parental samples had lower ratios of mutant versus wild-type allele compared with the fully heterozygote offspring.

  5. Recessive mutations in the alpha3 (VI) collagen gene COL6A3 cause early-onset isolated dystonia.

  6. Increased adipocyte COL6A3 expression associates with insulin (show INS Proteins) resistance; COL6A3 mRNA associates with small adipocyte size

  7. The heterozygous c.3353A>C mutation in exon 8 of the COL6A3 gene is associated with the Bethlem myopathy with autosomal dominant inheritance.

  8. This study showed that COL6A3 expression appeared to be lowered in obesity, whereas diet- and surgery-induced weight loss increased COL6A3 expression.

  9. Mutations in each of the three collagen VI genes, COL6A1 (show COL6A1 Proteins), COL6A2 (show COL6A2 Proteins) and COL6A3, cause four types of muscle disorders: Ullrich congenital muscular dystrophy, Bethlem myopathy, limb-girdle muscular dystrophy, and autosomal recessive myosclerosis. (Review)

  10. Data indicate that the aberrantly methylated and expressed genes in cancer process including IRS1 (show IRS1 Proteins) and collagen-related genes COL4A1 (show COL4A1 Proteins), COL4A2 (show COL4a2 Proteins) and COL6A3.

COL6a3 Protein Profile

Protein Summary

This gene encodes the alpha-3 chain, one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The alpha-3 chain of type VI collagen is much larger than the alpha-1 and -2 chains. This difference in size is largely due to an increase in the number of subdomains, similar to von Willebrand Factor type A domains, that are found in the amino terminal globular domain of all the alpha chains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in the type VI collagen genes are associated with Bethlem myopathy, a rare autosomal dominant proximal myopathy with early childhood onset. Mutations in this gene are also a cause of Ullrich congenital muscular dystrophy, also referred to as Ullrich scleroatonic muscular dystrophy, an autosomal recessive congenital myopathy that is more severe than Bethlem myopathy. Multiple transcript variants have been identified, but the full-length nature of only some of these variants has been described.

Gene names and symbols associated with COL6a3

  • collagen, type VI, alpha 3 (COL6A3)
  • collagen, type VI, alpha 3 (col6a3)
  • collagen, type VI, alpha 3 (Col6a3)
  • AI507288 protein
  • Col6a-3 protein
  • COL6A3 protein
  • wu:fb06e12 protein
  • wu:fs74g09 protein

Protein level used designations for COL6a3

collagen alpha-3(VI) chain , type VI collagen alpha 3 chain , alpha 3 type VI collagen , collagen, type VI, alpha 3 , collagen alpha-3(VI) chain-like , collagen alpha 3 chain type VI , collagen alpha3(VI) , procollagen, type VI, alpha 3 , type VI collagen alpha 3 subunit , collagen VI, alpha-3 polypeptide , alpha-3 collagen type VI , collagen type VI alpha 3

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694701 Macaca mulatta
100459849 Pongo abelii
100465530 Ailuropoda melanoleuca
12835 Mus musculus
367313 Rattus norvegicus
1293 Homo sapiens
396548 Gallus gallus
100101551 Sus scrofa
100716662 Cavia porcellus
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