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The protein encoded by CFHR3 is a secreted protein, which belongs to the complement factor H-related protein family. Additionally we are shipping CFHR3 Antibodies (11) and and many more products for this protein.
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These data provide evidence that FHR3, which is absent in patients with the autoimmune form of hemolytic uremic syndrome, is involved in B cell regulation
We describe a novel CFH (show CFH ELISA Kits)/CFHR3 hybrid gene secondary to a de novo 6.3-kb deletion that arose through microhomology-mediated end joining rather than nonallelic homologous recombination. We confirmed a transcript from this hybrid gene and showed a secreted protein product that lacks the recognition domain of factor H (show CFH ELISA Kits) and exhibits impaired cell surface complement regulation
Next-generation sequencing of the CFH (show CFH ELISA Kits) region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH (show CFH ELISA Kits)-related genes in the retina or RPE/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins.[CFHR3]
Studies indicate that complement factor H (show CFH ELISA Kits)-related proteins (FHR1 (show CFHR1 ELISA Kits)-5) may enhance complement activation, with important implications for the role of these proteins in disease.
These results suggest that the combination of quantitative and qualitative variations in the complement proteins encoded by CFH (show CFH ELISA Kits), CFHR3 and CFHR1 (show CFHR1 ELISA Kits) genes is key for the association of these haplotypes with disease.
Genetic variants in CFH, CFHR3, and CFHR1 affect complement activation and thereby predispose patients to develop IgA nephropathy.
Prompt use of immunosuppressive agents and plasma exchanges are useful for improving outcomes in pediatric patients with anti-complement factor H (show CFH ELISA Kits)-associated HUS (show CFH ELISA Kits).
Atypical haemolytic-uraemic syndrome due to heterozygous mutations of CFH (show CFH ELISA Kits)/CFHR1 (show CFHR1 ELISA Kits)-3 and complement factor H (show CFH ELISA Kits) 479.
we have assessed the relationship between GA and previously identified AMD (show AMD1 ELISA Kits)-associated variants of genes (CFH (show CFH ELISA Kits), CFB (show CFB ELISA Kits), C3, FHR1 (show CFHR1 ELISA Kits), FRH3, and ARMS2 (show ARMS2 ELISA Kits)/HTRA (show HTRA1 ELISA Kits)).
genetic variations in CFH (show CFH ELISA Kits) and its related genes may contribute to hypertension risk in Chinese Hans
The protein encoded by this gene is a secreted protein, which belongs to the complement factor H-related protein family. It binds to heparin, and may be involved in complement regulation. Mutations in this gene are associated with decreased risk of age-related macular degeneration, and with an increased risk of atypical hemolytic-uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
H factor-like 4
, H factor-like protein 3
, complement factor H-related protein 3