Cyclin T1 Proteins (CCNT1)

CCNT1 encodes a member of the highly conserved cyclin C subfamily. Additionally we are shipping Cyclin T1 Antibodies (58) and Cyclin T1 Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CCNT1 904 O60563
CCNT1 12455 Q9QWV9
Rat CCNT1 CCNT1 315291  
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Top Cyclin T1 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

CCNT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Cyclin T1 (CCNT1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Cyclin T1 (CCNT1) interaction partners

  1. We conclude that a subset of non-paused, pre-cellular genes are among the most susceptible to reduced P-TEFb (show CDK9 Proteins), SEC and Mediator levels in Drosophila embryos.

  2. following P-TEFb (show CDK9 Proteins) inhibition, most polymerases were restricted to within 150 bp of the transcription initiation site of the active Drosophila melanogaster Hsp70 gene, and live-cell imaging demonstrated that these polymerases were stably associated

Human Cyclin T1 (CCNT1) interaction partners

  1. Quantitative measurement of the molecular interactions among Tat (show TAT Proteins), CycT1 and CDK9 (show CDK9 Proteins) has showed that any third molecule enhances the binding between the other two molecules. These findings suggest that each component of the Tat:P-TEFb (show TEF Proteins) complex stabilizes the overall complex, thereby supporting the efficient transcriptional elongation during viral RNA synthesis.

  2. the introduction of HIV-1 Tat (show TAT Proteins) and Mg12+ ion resulted in the active site architectural characteristics of phosphorylated CDK9 (show CDK9 Proteins)/cyclin T1 complex

  3. AFF4 (show AFF4 Proteins) is positioned to make unexpected direct contacts with HIV Tat (show TAT Proteins), and Tat (show TAT Proteins) enhances P-TEFb/CCNT1 affinity for AFF4 (show AFF4 Proteins).

  4. Plk1 negatively regulates the RNA polymerase II-dependent transcription through inhibiting the activity of cyclin T1/Cdk9 (show CDK9 Proteins) complex.

  5. The sequence domain of human cytomegalovirus pUL97 responsible for the interaction with cyclin T1 was between amino acids 231-280.

  6. the release of P-TEFb from the 7SK snRNP (show LSM2 Proteins) led to increased synthesis of HEXIM1 (show HEXIM1 Proteins) but not HEXIM2 (show HEXIM2 Proteins)

  7. All of the hCD4/R5/cT1 (show CTF1 Proteins) mice developed disseminated infection of tissues that included the spleen, small intestine, lymph nodes and lungs after intravenous injection with an HIV-1 infectious molecular clone

  8. positive transcription elongation factor b (P-TEFb (show CDK9 Proteins), made of CDK9 (show CDK9 Proteins) and CycT1) is released from its inhibitory complex by histone deacetylase (show HDAC1 Proteins) inhibitors, which also activate HIV transcription

  9. CYCT1b is a newly identified cyclin T1 splice variant whose expression leads to direct inhibition of TAT (show TAT Proteins)-transactivated transcription of the HIV-1 LTR promoter

  10. Structural determination of a short-lived conformational state between CCNT1 and CDK9 (show CDK9 Proteins) that is adopted during the phosphorylation cycle.

Mouse (Murine) Cyclin T1 (CCNT1) interaction partners

  1. Data show that the minimal 90-amino acid AF9 (show MLLT3 Proteins) fragment in MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins) retains an ability to form higher order complexes with AF4*P-TEFb and with DOT1 (show DOT1L Proteins).

  2. Data show that the CDK9 (show CDK9 Proteins) and cyclin T1 subunits of P-TEFb are present in mouse oocytes and preimplantation embryos, and that CDK9 (show CDK9 Proteins) is essential for embryonic genome activation in the mouse.

  3. Cyclin T1 oncogenic function and suggest a role for this protein in controlling cell cycle probably via Rb/E2F1 (show E2F1 Proteins) pathway.

  4. CDK9 (show CDK9 Proteins) has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of cyclin T1 promotes its nuclear localization.

  5. P-TEFb is a key mediator of Myc (show MYC Proteins) activated transcription by stimulating elongation

  6. Tat (show TAT Proteins) and trans-activation-responsive (TAR (show RBM8A Proteins)) RNA-independent induction of HIV-1 long terminal repeat by this protein requires Sp1 (show SP1 Proteins).

  7. cyclin T1 binds with granulin (show GRN Proteins) to inhibit transcription

  8. location of the cyclin T1 gene regulatory elements is male germ cell-specific

  9. These data link the P-TEFb equilibrium to the intracellular transcriptional demand and proliferative/differentiated states of cells.

  10. knockdown of CycT1 from P-TEFb abolishes both of the different chromatin loops regulating CD4 (show CD4 Proteins) expression

Cyclin T1 (CCNT1) Protein Profile

Protein Summary

This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with Cyclin T1 Proteins (CCNT1)

  • Cyclin T (CycT)
  • cyclin T1 (CCNT1)
  • cyclin T1 (ccnt1)
  • cyclin T1 (LOC100352150)
  • cyclin T1 (Ccnt1)
  • 2810478G24Rik protein
  • AI115585 protein
  • anon-74EFc protein
  • CCNT protein
  • CG6292 protein
  • Cyclin-T1 protein
  • CycT1 protein
  • Dmcyclin T protein
  • Dmel\\CG6292 protein
  • dT protein
  • fi75b02 protein
  • HIVE1 protein
  • ORE-14 protein
  • P-TEFb protein
  • p124 protein
  • si:dkey-18f23.10 protein
  • wu:fi75b02 protein

Protein level used designations for Cyclin T1 Proteins (CCNT1)

CG6292-PA , CG6292-PB , CG6292-PC , CG6292-PD , CycT-PA , CycT-PB , CycT-PC , CycT-PD , CyclinT , cyclin T , cyclin T1 , cyclin T2 , dCyclin T , cyclin-T1-like , CDK9-associated C-type protein , cyclin C-related protein , cyclin-T1 , human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1 , cyclin-T , cycT1 , cyclin T1 protein

39961 Drosophila melanogaster
707754 Macaca mulatta
100170179 Xenopus (Silurana) tropicalis
100409876 Callithrix jacchus
100352150 Oryctolagus cuniculus
100583185 Nomascus leucogenys
904 Homo sapiens
12455 Mus musculus
315291 Rattus norvegicus
334465 Danio rerio
734952 Xenopus laevis
486564 Canis lupus familiaris
407194 Bos taurus
100033893 Equus caballus
450146 Pan troglodytes
100860835 Capra hircus
101106415 Ovis aries
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