Cytochrome B-245, beta Polypeptide Proteins (CYBB)

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. Additionally we are shipping CYBB Antibodies (115) and CYBB Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYBB 1536 P04839
CYBB 13058 Q61093
Rat CYBB CYBB 66021  
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Top CYBB Proteins at

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 15 to 18 Days

CYBB Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)

More Proteins for Cytochrome B-245, beta Polypeptide (CYBB) Interaction Partners

Zebrafish Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. The nox1 (show NOX1 Proteins), nox2/cybb expression in zebrafish during early nervous system development from 12 to 48 hours post fertilization

Rabbit Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. Data indicate that NADPH oxidase (show NOX1 Proteins) NOx2 inhibition attenuates endoplasmic reticulum (ER) stress and apoptosis.

Human Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. NOX2, NOX4 (show NOX4 Proteins), and mitochondrial-derived reactive oxygen species contribute to angiopoietin-1 (show ANGPT1 Proteins) signaling and angiogenic responses in endothelial cells.

  2. PFK-2 (show PFKFB3 Proteins) seems to be a strategic element that links NADPH oxidase (show NOX1 Proteins) activation and glycolysis modulation, and, as such, is proposed as a potential therapeutic target in inflammatory diseases.

  3. data support NOX2 as a critical component of the suppressive machinery of CD8 (show CD8A Proteins) Tregs and suggest that repairing NOX2 deficiency in these cells may protect older individuals from tissue-destructive inflammatory disease, such as large-vessel vasculitis.

  4. CD8 (show CD8A Proteins)+ T cells in close contact with target T cells release NADPH oxidase 2-containing microvesicles that inhibit TCR activation by elevating ROS (show ROS1 Proteins) and thereby reducing phosphorylation of the TCR-associated kinase ZAP70 (show ZAP70 Proteins).

  5. Thioredoxin (show TXN Proteins) attenuates oxidized low-density lipoprotein induced oxidative stress in human umbilical vein endothelial cells by reducing NOX2-NOX4 (show NOX4 Proteins) activity.

  6. Nox4 (show NOX4 Proteins)-derived H2O2 in part activates Nox2 to increase mitochondrial ROS (show ROS1 Proteins) via pSer36-p66Shc (show SHC1 Proteins), thereby enhancing VEGFR2 (show KDR Proteins) signaling and angiogenesis in endothelial cells.

  7. Cytochrome b558 (show CYBA Proteins) also traffics from a lysosomal pool to phagosomes and this is required to replenish oxidatively damaged NOX2.

  8. Nox4 (show NOX4 Proteins) should contribute to the pathological processes insubarachnoid hemorrhage(SAH (show ACSM3 Proteins))-induced early brain injury (EBI (show TBL1X Proteins)), and there was not an overlay effect of Nox2 inhibition and Nox4 (show NOX4 Proteins) inhibition on preventing SAH (show ACSM3 Proteins)-induced EBI (show TBL1X Proteins).

  9. NADPH oxidase (show NOX1 Proteins) promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson's disease

  10. TLR4 (show TLR4 Proteins)- and TLR2-induced IRAK (show IRAK1 Proteins)-ERK (show EPHB2 Proteins) pathway cross-talks with p67phox (show NCF2 Proteins)-Nox-2 for reactive oxygen species generation, thus regulating IL-1beta (show IL1B Proteins) transcription and processing in monocytic cells.

Cow (Bovine) Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. Data indicate that the efficiency of NADPH oxidase (show NOX1 Proteins) enzymatic activity is higher at endoplasmic reticulum (ER).

  2. A p47(phox) and Src kinase activation of peroxide production by Nox2 appears to be an important contributor to vascular contractile mechanisms mediated through activation of protein kinase C

Mouse (Murine) Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. Nox2- and Nox4 (show NOX4 Proteins)-derived reactive oxygen species contribute to stem cell pluripotency maintenance and self-renewal.

  2. Redox-dependent regulation of EGFR (show EGFR Proteins) activation in airway epithelial cells was found to strongly depend on activation of either DUOX1 (show DUOX1 Proteins) or NOX2.

  3. NOX2 signaling in macrophages participates in the pathogenesis of obesity, and reinforce a key role for macrophage inflammation in diet-induced metabolic and neurologic decline

  4. Studies in knockout and knock-in mice showed that the phospholipase A2 (show YWHAZ Proteins) activity of peroxiredoxin 6 (show PRDX6 Proteins) activates NOX2 in cultured pulmonary endothelial cells and alveolar macrophages, clarifying the metabolism of lysophosphatidyl chold to lysophosphatidic acid.

  5. NOX2 knockout mice had significantly lower blood pressure than littermate controls, with both endothelial cells and myeloid cells having a deficiency in NOX2.

  6. Data show that pan-NOX-inhibitor APX-115 treatment decreased NADPH oxidase (show NOX1 Proteins) (Nox) Nox1 (show NOX1 Proteins), Nox2, and Nox4 (show NOX4 Proteins) protein expression in the kidney.

  7. NOX2 regulates proinflammatory TLR signaling and alveolar remodeling induced by a single dose of lipopolysaccharides.

  8. a deficiency in MyD88 (show MYD88 Proteins) or CybB is associated with impaired bacterial clearance and increased granuloma formation in the lung.

  9. NOX2 isoform was first discovered as a component of the oxidative burst in neutrophils and is a complex consisting of several cytosolic subunits (p47phox, p67phox (show NCF2 Proteins), p40phox (show NCF4 Proteins), and Rac1 or Rac2 (show RAC2 Proteins)) and a membrane-associated cytochrome b558 (show CYBA Proteins) reductase made up of gp91phox and p22phox (show CYBA Proteins) subunits.

  10. Macrophage-produced HMGB1 (show HMGB1 Proteins) leads to aortic inflammation and acts as a trigger for CD4 (show CD4 Proteins)(+) T-cell-produced IL-17 (show IL17A Proteins) during abdominal aortic aneurysm formation. HMGB1 (show HMGB1 Proteins) release is dependent on Nox2 activation, which can be inhibited by MSCs leading to attenuation of proinflammatory cytokines and protection against AAA (show AAAS Proteins) formation.

Pig (Porcine) Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. sub-vasomotor concentration of ET-1 (show EDN1 Proteins) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Proteins) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Proteins) following ETA receptor activation

  2. Reactive oxygen species generated by NADPH oxidase (show NOX1 Proteins) contribute to the aberrant pulmonary arterial responses in piglets exposed to 3 days of hypoxia.

  3. Upregulation of PPAR-gamma and NADPH oxidases are involved in restenosis.

CYBB Protein Profile

Protein Summary

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase\; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.

Gene names and symbols associated with CYBB

  • cytochrome b-245, beta polypeptide (chronic granulomatous disease) (cybb)
  • cytochrome b-245, beta polypeptide (cybb)
  • cytochrome b-245, beta polypeptide (chronic granulomatous disease) (CYBB)
  • cytochrome b-245, beta polypeptide (CYBB)
  • cytochrome b-245 beta polypeptide (CYBB)
  • cytochrome b-245, beta polypeptide (Cybb)
  • NADPH oxidase heavy chain subunit (GP91-PHOX)
  • AMCBX2 protein
  • C88302 protein
  • Cgd protein
  • CGD91-phox protein
  • CYBB protein
  • Cyd protein
  • GP91-1 protein
  • Gp91-phox protein
  • GP91PHOX protein
  • NOX1 protein
  • Nox2 protein
  • p91-PHOX protein
  • zgc:64144 protein

Protein level used designations for CYBB

cytochrome b-245, beta polypeptide , gp91 , NADPH oxidase 2 , cytochrome b-245, beta polypeptide (chronic granulomatous disease) , Cytochrome b-245 heavy chain , NADPH oxidase heavy chain subunit , NADPH oxidase 1 , NADPH oxidase flavocytochrome b subunit , cytochrome b-245 heavy chain , gp91-phox , CGD91-phox , cytochrome b(558) subunit beta , cytochrome b558 subunit beta , heme-binding membrane glycoprotein gp91phox , neutrophil cytochrome b 91 kDa polypeptide , p22 phagocyte B-cytochrome , superoxide-generating NADPH oxidase heavy chain subunit , gp91-1 , endothelial type gp91-phox , predicted NADPH oxidase-2

393386 Danio rerio
595081 Xenopus (Silurana) tropicalis
696542 Macaca mulatta
444353 Xenopus laevis
100036757 Ovis aries
100270807 Salmo salar
100008801 Oryctolagus cuniculus
1536 Homo sapiens
418581 Gallus gallus
281112 Bos taurus
13058 Mus musculus
66021 Rattus norvegicus
491825 Canis lupus familiaris
397108 Sus scrofa
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