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Cytochrome B-245, beta Polypeptide Proteins (CYBB)

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. Additionally we are shipping CYBB Antibodies (116) and CYBB Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYBB 1536 P04839
CYBB 13058 Q61093
Rat CYBB CYBB 66021  
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Top CYBB Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 11 to 13 Days
$774.40
Details

CYBB Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)
,

More Proteins for Cytochrome B-245, beta Polypeptide (CYBB) Interaction Partners

Rabbit Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. Data indicate that NADPH oxidase (show NOX1 Proteins) NOx2 inhibition attenuates endoplasmic reticulum (ER) stress and apoptosis.

Human Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. The ROS (show ROS1 Proteins) levels of the study group decreased obviously before irradiation (P<0.01), however, the radiation-induced ROS (show ROS1 Proteins) of the study group was at a high level even when irradiation had been terminated for 2 h (P<0.01). Moreover, NOX2 and NOX4 (show NOX4 Proteins) levels and total SOD (show SOD1 Proteins) activity decreased (P<0.01), while the levels of SOD1 (show SOD1 Proteins) were stably maintained (P>0.05).

  2. The authors report the absence of an oxidative burst in the phagocytes of the patient with a novel missense c.1226C > A mutation in the CYBB gene resulting in p.A409E.

  3. alkali burns markedly upregulated the transcription and expression of Nox2 and Nox4 (show NOX4 Proteins) in human or mouse corneas.

  4. These findings provide novel insights into oleanolic acid-induced inhibition of rectal cancer cell proliferation and highlight NOX2/ROS (show ROS1 Proteins)/HIF-1alpha (show HIF1A Proteins) axis as a novel therapeutic target for the treatment of rectal cancer.

  5. NOX2 induces antigen release from endosomes for cross-presentation by direct oxidation of endosomal lipids.

  6. Critical role of the Mac1 (show ITGAM Proteins)/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration

  7. Female patients with severe inflammatory bowel disease should be checked for X-CGD genes.

  8. Blunting of NOX2-dependent IKKepsilon (show IKBKE Proteins) oncogenic kinase expression reduces proliferation and viability of human breast cancer cells.

  9. Furthermore, a direct interaction between AnkA and HDAC1 (show HDAC1 Proteins) was detected at the CYBB promoter, and was critical for AnkA-mediated CYBB repression.

  10. There is a mutual enhancement between HMGB1 (show HMGB1 Proteins) and Nox2-derived reactive oxygen species in the diabetic retina.

Cow (Bovine) Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. Data indicate that the efficiency of NADPH oxidase (show NOX1 Proteins) enzymatic activity is higher at endoplasmic reticulum (ER).

  2. A p47(phox) and Src kinase activation of peroxide production by Nox2 appears to be an important contributor to vascular contractile mechanisms mediated through activation of protein kinase C

Mouse (Murine) Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. alkali burns markedly upregulated the transcription and expression of Nox2 and Nox4 (show NOX4 Proteins) in human or mouse corneas.

  2. the present study demonstrates that nNOS-derived NO signaling modulated by spinal Sig-1R activation increases Nox2 activity and concomitant ROS production, which leads to a ROS-induced increase in PKC-dependent pGluN1 expression in the spinal cord dorsal horn and the development of pain hypersensitivity

  3. Findings indicate the role of Tiam1 (show TIAM1 Proteins)-Rac1-Nox2 signaling pathway in the onset of spontaneous diabetes in the type 1 diabetes NOD mouse model.

  4. Data show that Ewha-18278 displayed NADPH oxidase 2 (Nox2) inhibition.

  5. Data suggested that NADPH oxidase 2-derived reactive oxygen species in hippocampal microglia, at least in part, contributes to subsequent neuroinflammation and cognitive impairments induced by surgery in aged mice.

  6. NOX2 induces antigen release from endosomes for cross-presentation by direct oxidation of endosomal lipids.

  7. results indicate that long-term UVA eye irradiation led to increased gp91phox-derived ROS (show ROS1 Proteins) in the brain and the increased expression of urocortin 2 (show UTS2 Proteins) and CRHR (show CRHR1 Proteins) type 2, resulting in photoaging; however, further studies are needed to confirm these findings

  8. NADPH oxidase 2 inactivation causes regression of vascularization and the size and stability of atherosclerotic plaques

  9. Nox2 is implicated in the inflammatory and neovascular response to corneal chemical injury in mice

  10. NOX2 has a role in oxidative stress and mitochondrial abnormalities caused by saturated fat in cardiomyocytes

Pig (Porcine) Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. sub-vasomotor concentration of ET-1 (show EDN1 Proteins) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Proteins) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Proteins) following ETA receptor activation

  2. Reactive oxygen species generated by NADPH oxidase (show NOX1 Proteins) contribute to the aberrant pulmonary arterial responses in piglets exposed to 3 days of hypoxia.

  3. Upregulation of PPAR-gamma (show PPARG Proteins) and NADPH (show NQO1 Proteins) oxidases are involved in restenosis.

CYBB Protein Profile

Protein Summary

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase\; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.

Gene names and symbols associated with CYBB

  • cytochrome b-245, beta polypeptide (chronic granulomatous disease) (cybb)
  • cytochrome b-245, beta polypeptide (cybb)
  • cytochrome b-245, beta polypeptide (chronic granulomatous disease) (CYBB)
  • cytochrome b-245, beta polypeptide (CYBB)
  • cytochrome b-245 beta polypeptide (CYBB)
  • cytochrome b-245, beta polypeptide (Cybb)
  • NADPH oxidase heavy chain subunit (GP91-PHOX)
  • AMCBX2 protein
  • C88302 protein
  • Cgd protein
  • CGD91-phox protein
  • CYBB protein
  • Cyd protein
  • GP91-1 protein
  • Gp91-phox protein
  • GP91PHOX protein
  • NOX1 protein
  • Nox2 protein
  • p91-PHOX protein
  • zgc:64144 protein

Protein level used designations for CYBB

cytochrome b-245, beta polypeptide , gp91 , NADPH oxidase 2 , cytochrome b-245, beta polypeptide (chronic granulomatous disease) , Cytochrome b-245 heavy chain , NADPH oxidase heavy chain subunit , NADPH oxidase 1 , NADPH oxidase flavocytochrome b subunit , cytochrome b-245 heavy chain , gp91-phox , CGD91-phox , cytochrome b(558) subunit beta , cytochrome b558 subunit beta , heme-binding membrane glycoprotein gp91phox , neutrophil cytochrome b 91 kDa polypeptide , p22 phagocyte B-cytochrome , superoxide-generating NADPH oxidase heavy chain subunit , gp91-1 , endothelial type gp91-phox , predicted NADPH oxidase-2

GENE ID SPECIES
393386 Danio rerio
595081 Xenopus (Silurana) tropicalis
696542 Macaca mulatta
444353 Xenopus laevis
100036757 Ovis aries
100270807 Salmo salar
100008801 Oryctolagus cuniculus
1536 Homo sapiens
418581 Gallus gallus
281112 Bos taurus
13058 Mus musculus
66021 Rattus norvegicus
491825 Canis lupus familiaris
397108 Sus scrofa
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