Cytohesin 3 Proteins (CYTH3)

CYTH3 encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. Additionally we are shipping Cytohesin 3 Antibodies (47) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYTH3 9265 O43739
CYTH3 19159 O08967
CYTH3 116693  
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Top Cytohesin 3 Proteins at

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 2 to 3 Days

CYTH3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Cytohesin 3 (CYTH3) Interaction Partners

Human Cytohesin 3 (CYTH3) interaction partners

  1. Cytohesin-3 was upregulated in hepatocellular carcinoma tissues, correlating with overall survival/relapse-free survival and tumor size/vascular invasion.

  2. The PH domains of cytohesin 2/ARNO (show CYTH2 Proteins) and cytohesin 3/GRP1 are responsible for the differential effects of these proteins on cell adhesion to fibronectin (show FN1 Proteins).

  3. incorporation of the E345K charge reversal mutation into the GRP1 PH domain enhances PI(4,5)P(2) affinity 8-fold and yields constitutive plasma membrane targeting in cells

  4. GRP1 is a new corepressor for thyroid hormone (show PTH Proteins) receptors, which modulates both positive and negative regulation by T3 by decreasing TR-complex formation on thyroid response elements

Mouse (Murine) Cytohesin 3 (CYTH3) interaction partners

  1. Mutation of a key residue (K273A) within the canonical phosphatidylinositol phosphate - binding site of Grp1 significantly reduced the free energy of phosphatidylinositol phosphate binding.

  2. Grp1 localizes at the beta1 integrin-positive intracellular compartment, and is involved in HGF (show HGF Proteins)-dependent Arf6 (show ARF6 Proteins) activation, beta1 integrin recycling and tumour angiogenesis and growth in mice.

  3. These observations suggest that Grp1 family guanine nucleotide exchange factors are autoregulated by mechanisms that depend on plasma membrane recruitment for activation.

Cytohesin 3 (CYTH3) Protein Profile

Protein Summary

This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.

Gene names and symbols associated with Cytohesin 3 Proteins (CYTH3)

  • cytohesin 3 (CYTH3)
  • cytohesin 3 (cyth3)
  • Cytohesin 3 (Bm1_39360)
  • cytohesin 3 (Cyth3)
  • AI648983 protein
  • ARNO3 protein
  • CLM3 protein
  • CYTH3 protein
  • Grp1 protein
  • MGC145373 protein
  • Pscd3 protein
  • Sec7 protein
  • Sec7C protein

Protein level used designations for Cytohesin 3 Proteins (CYTH3)

cytohesin 3 , pleckstrin homology, Sec7 and coiled-coil domains 3 , Cytohesin 3 , ARF nucleotide-binding site opener 3 , PH, SEC7 and coiled-coil domain-containing protein 3 , cytohesin-3 , general receptor of phosphoinositides 1 , SEC7 homolog C , mSec7-3 , pleckstrin homology, Sec7 and coiled/coil domains 3 , rSec7-3

609100 Canis lupus familiaris
618488 Bos taurus
780343 Xenopus (Silurana) tropicalis
6102756 Brugia malayi
100027123 Monodelphis domestica
9265 Homo sapiens
19159 Mus musculus
116693 Rattus norvegicus
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