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DNA (Cytosine-5)-Methyltransferase 1 Proteins (DNMT1)

DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Additionally we are shipping DNA (Cytosine-5)-Methyltransferase 1 Antibodies (387) and DNA (Cytosine-5)-Methyltransferase 1 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DNMT1 1786 P26358
Rat DNMT1 DNMT1 84350  
DNMT1 13433 P13864
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Top DNA (Cytosine-5)-Methyltransferase 1 Proteins at

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 49 to 54 Days
Insect Cells Mouse Un-conjugated 300 U Log in to see 7 to 8 Days
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Sf-9 cells Human GST tag   10 μg Log in to see 1 to 2 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

DNMT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,

Top referenced DNA (Cytosine-5)-Methyltransferase 1 Proteins

  1. Mouse (Murine) DNMT1 Protein expressed in Insect Cells - ABIN2452167 : Takeshita, Suetake, Yamashita, Suga, Narita, Nakagawa, Tajima: Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1). in Proceedings of the National Academy of Sciences of the United States of America 2011 (PubMed)
    Show all 2 references for ABIN2452167

More Proteins for DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) Interaction Partners

Zebrafish DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. Dnmt1 stability requires UHRF1 (show UHRF1 Proteins) phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation

  2. Lsh (show HELLS Proteins) Is Essential for Maintaining Global DNA Methylation (show HELLS Proteins) Levels in Amphibia and Fish and Interacts Directly with Dnmt1.

  3. Dnmt1 is required for hematopoietic stem and progenitor cells maintenance via cebpa (show CEBPA Proteins) regulation during definitive hematopoiesis in zebrafish

  4. These data provide the first evidence that Uhrf1 (show UHRF1 Proteins) and Dnmt1 function is required for vertebrate lens development and maintenance.

  5. These results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 (show SUV39H1 Proteins) and that, together, Dnmt1 and Suv39h1 (show SUV39H1 Proteins) help guide the terminal differentiation of particular tissues.

  6. Data show that in dnmt1 homozygous mutants, reactivation of gfp expression occurs in a reproducible subset of cells, raising the possibility of different sensitivities or alternative silencing mechanisms in discrete cell populations.

  7. Thus, our data suggest that Dnmt1 is dispensable for pancreatic duct or endocrine cell formation, but not for acinar cell survival. In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors.

Human DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. The inhibition of DNMT1 contributed to the activation of p53 (show TP53 Proteins) pathways.

  2. Results show that miR (show MLXIP Proteins)-148a is down-regulated in urothelial cell carcinoma of the bladder cell lines. Its overexpression leads to induction of apoptosis in part by down-regulating DNMT1.

  3. These data suggest that targeting the IL-8 (show IL8 Proteins)/AKT1 (show AKT1 Proteins) signaling pathway and DNMT1 may provide a potential therapeutic approach for blocking NPC (show NPC1 Proteins) metastasis.

  4. miR (show MLXIP Proteins)-140-5p at least partly targets Dnmt1 and regulates SOD2 (show SOD2 Proteins) expression to inhibit proliferation and promote apoptosis and differentiation of HPASMCs in hypoxia

  5. Data indicate an epigenetic prognostic signature in glioblastomas based on expression of polycomb (show CBX2 Proteins) repressive complex 2 (EZH2 (show EZH2 Proteins)), DNA-methyltransferases DNMT1 and 3B which can be used easily in routine neuropathology practice.

  6. the abundance of BDNF (show BDNF Proteins) positively correlated and phosphorylated DNMT1 inversely correlated with that of FKBP51 (show FKBP4 Proteins) in cells

  7. miR (show MLXIP Proteins)-124 and miR (show MLXIP Proteins)-506 inhibit progression and increase sensitivity to chemotherapy by targeting DNMT3B (show DNMT3B Proteins) and DNMT1 in colorectal carcinoma.

  8. To correlate DNMTs expression with DNA methylation (show HELLS Proteins), DNMT1, DNMT3A (show DNMT3A Proteins) and DNMT3B (show DNMT3B Proteins) mRNA levels in 5 colorectal cancer cell lines; results suggest that cellular DNMT expression is positively correlated with global DNA methylation (show HELLS Proteins) level but not with regional DNA hypermethylation at each locus.

  9. Phosphorylated p38 (show CRK Proteins), DNMT1 and AChE were aberrantly expressed in a subset of hepatocellular carcinoma tumors.

  10. We further demonstrate that such fibroblast activation is dependent on phosphate influx, aberrant phosphorylation of DNA methyltransferase DNMT1 and aberrant CpG island promoter methylation.

Pig (Porcine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. Dnmt1 was indispensable for oocyte cytoplasmic maturation, providing a novel role for Dnmt1 in the regulation of oocyte maturation.

  2. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a (show DNMT3A Proteins), Hdac1 (show HDAC1 Proteins), Kdm3a (show KDM3A Proteins) and Uhrf1 (show UHRF1 Proteins) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

  3. DNMT1o is localized mainly in the nuclei of oocytes and early embryos, whereas DNMT1s is expressed in the ooplasm cortex of oocytes and cytoplasm of early embryos.

  4. results indicate that loss of Dnmt1 in the maternal nucleus during SCNT significantly contributes to the unfaithful maintenance of methylation imprints in cloned embryos

  5. Oocyte-specific Dnmt1 is cytoplasmic during early development.

  6. Dnmt1 mRNA abundance plays an important role during protein regulation, Dnmt1 enzyme is mainly posttranscriptionally regulated.

Cow (Bovine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. Through down-regulating the expression of DNMT1, miR (show MYLIP Proteins)-152 reduced Global DNA methylation (show HELLS Proteins) and the activity of DNMT to reactivate the lactation signal transduction genes Akt (show AKT1 Proteins) and Ppar gamma (show PPARG Proteins).

  2. More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 (show ASCL2 Proteins) mRNA was present at highest levels in transgenic SCNT embryos.

  3. Our results indicate an essential role for Dnmt1 during bovine preimplantation development (show MTA2 Proteins), and suggest proper transcriptional reprogramming of this gene family in SCNT embryos.

  4. Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes, it enters the nuclei of 8-16 cell stage embryos

  5. Abnormal gene expression of DNMT, INFT, and MHC1 was noted in the majority of cloned embryos, indicating inefficient nuclear reprogramming and retarded embryo development.

  6. Results describe the alternative splicing and expression analysis of bovine DNA methyltransferase 1.

  7. Report inhibition of DNA methyltransferase 1 expression in bovine fibroblast cells used for nuclear transfer.

Arabidopsis thaliana DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. MET1 is a thylakoid-associated TPR protein involved in photosystem II supercomplex formation and repair in Arabidopsis

  2. Met1 gene expression throughout normal development, particularly in the flower

  3. MET1 is a contributor to epigenetic diversity in Arabidopsis.

  4. VIM (show VIM Proteins) proteins regulate genome-wide epigenetic gene silencing through coordinated modulation of DNA methylation (show HELLS Proteins) and histone modification status in collaboration with MET1

  5. VIM (show VIM Proteins) proteins function in transcriptional regulation via their roles in the MET1 DNA methylation (show HELLS Proteins) pathway.

  6. Genetic studies indicate that the Polycomb (show CBX2 Proteins) Repressive Complex 2 (PRC2) but not the DNA METHYLTRANSFERASE1 (MET1) is involved in regulating imprinted expression in the embryo. [MET1]

  7. MET1 restores body methylation, which is region-specific but random with respect to the affected CG sites, and is moderately although not decisively influenced by transcription.

  8. There is a mechanistic link between two major epigenetic pathways involved in histone and DNA methylation (show HELLS Proteins) in plants by physical interaction of MET1 with the FIS-PRC2 core component MEA.

  9. Our results bear interesting similarities with cancer cells, which show global losses of DNA methylation (show HELLS Proteins) but ectopic hypermethylation of genes previously marked by H3K27m3.

  10. An intergenic nucleosome-free crossover hotspot 3a undergoes increased recombination activity in met1.

Mouse (Murine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. Cigarette smoke induces proteosomal-mediated degradation of DNMT1 in embryonic orofacial cells.

  2. the abundance of BDNF (show BDNF Proteins) positively correlated and phosphorylated DNMT1 inversely correlated with that of FKBP51 (show FKBP5 Proteins) in cells

  3. we suggest that 14-3-3 (show YWHAQ Proteins) is a crucial reader of DNMT1pSer143 that regulates DNA methylation (show HELLS Proteins) and altered gene expression that contributes to cell invasion

  4. The replication foci targeting sequence domain, not the proliferating cell nuclear antigen (show PCNA Proteins) - binding domain, is solely responsible for the replication-coupled DNA methylation (show HELLS Proteins).

  5. The expression of DNMT1 and DNMT3b was decreased at 1 mT, and 50 Hz ELF-EMF can increase the expression...the alterations of genome-wide methylation and DNMTs expression may play an important role in the biological effects of 50 Hz ELF-EMF exposure

  6. Data suggest Fabp4 (show FABP4 Proteins) is up-regulated and DNA methylation (show HELLS Proteins) is down-regulated in aorta in hyperhomocysteinemia induced by high-methionine diet; up-regulation of DNA methyltransferase 1 (Dnmt1) promotes DNA methylation (show HELLS Proteins) and decreases Fabp4 (show FABP4 Proteins) expression.

  7. Obesity-induced, pro-inflammatory cytokines promote DNMT1 expression and its hypermethylation of the adiponectin (show ADIPOQ Proteins) promoter, suppressing adiponectin (show ADIPOQ Proteins) expression and exacerbating insulin (show INS Proteins) resistance.

  8. Dnmt1 is indispensable for mammary stem cell and mammary cancer stem cell maintenance, and for mammary tumorigenesis. Dnmt1 hypermethylates and downregulates ISL1 (show ISL1 Proteins) in mammary tumors and cancer stem cells.

  9. The hypermethylation of KLF4 (show KLF4 Proteins) directly mediated by Dnmt1 contributes to the progression of EMT (show ITK Proteins) in renal epithelial cells.

  10. the presence of DNMT1 in adult neural stem/precursor cells is crucial for the survival of newly generated neurons, but is dispensable once they accomplish neuronal differentiation in the adult hippocampus.

DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) Protein Profile

Protein Summary

DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DNMT1

  • DNA (cytosine-5-)-methyltransferase 1 (DNMT1)
  • DNA (cytosine-5-)-methyltransferase 1 (dnmt1)
  • DNA (cytosine-5-)-methyltransferase 1 (Dnmt1)
  • DNA (cytosine-5)-methyltransferase 1 (MET1)
  • DNA methyltransferase (cytosine-5) 1 (Dnmt1)
  • ADCADN protein
  • AIM protein
  • cb983 protein
  • cb1075 protein
  • Cxxc9 protein
  • DDM2 protein
  • dmnt1 protein
  • DMT01 protein
  • DMT1 protein
  • Dnmt protein
  • Dnmt1o protein
  • fb05h01 protein
  • HSN1E protein
  • m.MmuI protein
  • MCMT protein
  • Met-1 protein
  • Met1 protein
  • MET2 protein
  • methyltransferase 1 protein
  • METI protein
  • MommeD2 protein
  • mta protein
  • MTase protein
  • wu:fb05h01 protein

Protein level used designations for DNMT1

DNA (cytosine-5)-methyltransferase 1 , ddn , CXXC-type zinc finger protein 9 , DNA MTase HsaI , DNA methyltransferase HsaI , m.HsaI , DNA methyltransferase 1 , DNA (cytosine 5 ) methyltransferase 1 , DNA methyltransferase (cytosine 5 ) methyltransferase , DNA methyltransferase b , DNA MTase RnoIP , DNA methyltransferase (cytosine-5) 1 , DNA methyltransferase I , MCMT , m.RnoIP , DNA MTase GgaI , DNA MeTase , DNA methyltransferase GgaI , m.GgaI , DNA MTase MmuI , DNA methyltransferase MmuI

443549 Ovis aries
30430 Danio rerio
1786 Homo sapiens
476715 Canis lupus familiaris
606746 Sus scrofa
281119 Bos taurus
84350 Rattus norvegicus
396011 Gallus gallus
834975 Arabidopsis thaliana
13433 Mus musculus
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