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DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Additionally we are shipping DNA (Cytosine-5)-Methyltransferase 1 Antibodies (489) and DNA (Cytosine-5)-Methyltransferase 1 Kits (28) and many more products for this protein.
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Mouse (Murine) DNMT1 Protein expressed in Insect Cells - ABIN2452167
Takeshita, Suetake, Yamashita, Suga, Narita, Nakagawa, Tajima: Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1). in Proceedings of the National Academy of Sciences of the United States of America 2011
Show all 2 Pubmed References
Dnmt1 stability requires UHRF1 (show UHRF1 Proteins) phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation
Lsh (show HELLS Proteins) Is Essential for Maintaining Global DNA Methylation (show HELLS Proteins) Levels in Amphibia and Fish and Interacts Directly with Dnmt1.
Dnmt1 is required for hematopoietic stem and progenitor cells maintenance via cebpa (show CEBPA Proteins) regulation during definitive hematopoiesis in zebrafish
These data provide the first evidence that Uhrf1 (show UHRF1 Proteins) and Dnmt1 function is required for vertebrate lens development and maintenance.
These results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 (show SUV39H1 Proteins) and that, together, Dnmt1 and Suv39h1 (show SUV39H1 Proteins) help guide the terminal differentiation of particular tissues.
Data show that in dnmt1 homozygous mutants, reactivation of gfp expression occurs in a reproducible subset of cells, raising the possibility of different sensitivities or alternative silencing mechanisms in discrete cell populations.
Thus, our data suggest that Dnmt1 is dispensable for pancreatic duct or endocrine cell formation, but not for acinar cell survival. In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors.
Data show that silencing DNA methyltransferase 1 (DNMT1) increased expression of tumor suppressor genes, RASSF1A (show RASSF1 Proteins) and DAPK (show DAPK1 Proteins), in esophageal squamous cell carcinoma (ESCC) cells and ESCC xenograft in nude mice.
DNMT1, DNMT3A (show DNMT3A Proteins), and DNMT3B (show DNMT3B Proteins) were overexpressed in 36.9, 26, and 23 % of the OSCC patients, respectively. DNMT1 overexpression was significantly associated with the overall survival, p = 0.029, and relapse-free survival of OSCC patients, p = 0.003. Patients with DNMT1 overexpression, as an independent prognostic factor, had a 2.385 times higher risk to relapse than those with lower expression. The DNMT1 A201G gene polymorphi
H19 (show NCKAP1 Proteins) promoted proliferation and invasion of breast cancer through the miR (show MLXIP Proteins)-152/DNMT1 axis, providing a novel mechanism about the occurrence and development of breast cancer.
Placental DNMT1 expression was found to be associated positively with placental weight and birth weight, specifically in the female appropriate for gestational age births.
Variability in placental telomere length is associated with alterations in DNAm at TERT (show TERT Proteins), DNMT1, and DNMT3a (show DNMT3A Proteins).
the regulatory and functional interplay between DNA methylation (show HELLS Proteins) and tyrosine kinase (show TXK Proteins) signaling in propelling tumorigenesis, providing a widely applicable approach for targeting lung cancer.
Dnmt1 and Dnmt3a (show DNMT3A Proteins) are critical regulators for epigenetic silencing of endothelial cell marker genes.
malignant proliferation without differentiation, also referred to as cancer "stem" cell self-renewal, hinges on druggable corepressors. Inhibiting these corepressors (e.g., DNMT1) releases p53 (show TP53 Proteins)-independent terminal differentiation in cancer stem cells but preserves self-renewal of normal stem cells that express stem cell transcription factors
Study demonstrated that the lncRNA H19 (show NCKAP1 Proteins) promoted LSCC progression via miR (show MLXIP Proteins)-148a-3p and DNMT1.
DNMT1 up-regulation induced by IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) signaling was indispensable for IL-6 (show IL6 Proteins)-mediated hepaCAM (show HEPACAM Proteins) loss in renal cell carcinoma (show MOK Proteins) (RCC (show XRCC1 Proteins)) cell lines ACHN (show LARP6 Proteins) and 769-P, while DNMT3b (show DNMT3B Proteins) up-regulation was crucial for hepaCAM (show HEPACAM Proteins) loss in A498.
Dnmt1 was indispensable for oocyte cytoplasmic maturation, providing a novel role for Dnmt1 in the regulation of oocyte maturation.
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a (show DNMT3A Proteins), Hdac1 (show HDAC1 Proteins), Kdm3a (show KDM3A Proteins) and Uhrf1 (show UHRF1 Proteins) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
DNMT1o is localized mainly in the nuclei of oocytes and early embryos, whereas DNMT1s is expressed in the ooplasm cortex of oocytes and cytoplasm of early embryos.
results indicate that loss of Dnmt1 in the maternal nucleus during SCNT significantly contributes to the unfaithful maintenance of methylation imprints in cloned embryos
Oocyte-specific Dnmt1 is cytoplasmic during early development.
Dnmt1 mRNA abundance plays an important role during protein regulation, Dnmt1 enzyme is mainly posttranscriptionally regulated.
DNMT1 silencing significantly decreased the methylation levels of miR (show MYLIP Proteins)-29b promoter, up-regulated miR (show MYLIP Proteins)-29b expression and inhibited bovine viral diarrhea virus replication.
Through down-regulating the expression of DNMT1, miR (show MYLIP Proteins)-152 reduced Global DNA methylation (show HELLS Proteins) and the activity of DNMT to reactivate the lactation signal transduction genes Akt (show AKT1 Proteins) and Ppar gamma (show PPARG Proteins).
More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 (show ASCL2 Proteins) mRNA was present at highest levels in transgenic SCNT embryos.
Our results indicate an essential role for Dnmt1 during bovine preimplantation development (show MTA2 Proteins), and suggest proper transcriptional reprogramming of this gene family in SCNT embryos.
Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes, it enters the nuclei of 8-16 cell stage embryos
Abnormal gene expression of DNMT, INFT, and MHC1 was noted in the majority of cloned embryos, indicating inefficient nuclear reprogramming and retarded embryo development.
Results describe the alternative splicing and expression analysis of bovine DNA methyltransferase 1.
Report inhibition of DNA methyltransferase 1 expression in bovine fibroblast cells used for nuclear transfer.
MET1 is a thylakoid-associated TPR protein involved in photosystem II supercomplex formation and repair in Arabidopsis
Met1 gene expression throughout normal development, particularly in the flower
MET1 is a contributor to epigenetic diversity in Arabidopsis.
VIM (show VIM Proteins) proteins regulate genome-wide epigenetic gene silencing through coordinated modulation of DNA methylation (show HELLS Proteins) and histone modification status in collaboration with MET1
VIM (show VIM Proteins) proteins function in transcriptional regulation via their roles in the MET1 DNA methylation (show HELLS Proteins) pathway.
Genetic studies indicate that the Polycomb (show CBX2 Proteins) Repressive Complex 2 (PRC2) but not the DNA METHYLTRANSFERASE1 (MET1) is involved in regulating imprinted expression in the embryo. [MET1]
MET1 restores body methylation, which is region-specific but random with respect to the affected CG sites, and is moderately although not decisively influenced by transcription.
There is a mechanistic link between two major epigenetic pathways involved in histone and DNA methylation (show HELLS Proteins) in plants by physical interaction of MET1 with the FIS-PRC2 core component MEA.
Our results bear interesting similarities with cancer cells, which show global losses of DNA methylation (show HELLS Proteins) but ectopic hypermethylation of genes previously marked by H3K27m3.
An intergenic nucleosome-free crossover hotspot 3a undergoes increased recombination activity in met1.
Data from studies using mouse embryonic fibroblasts suggest that cell proliferation rate positively correlates with expression of Dnmt1 in G1 phase; global DNA methylation (show HELLS Proteins) is significantly higher in G1 phase than in G2/M phase; larger methylation differences are observed on promoters of pluripotency-related genes; thus, high cell proliferation rates promote generation of induced pluripotent stem cells.
Dnmt1 and Ezh2 (show EZH2 Proteins) play distinct roles in the different islet cell types
we extended this work by using a biotinylation tagging approach to characterize DNMT1 protein complexes in mouse erythroleukemic cells. We identified novel DNMT1 interactions with several hematopoietic transcription factors with essential roles in erythroid differentiation
The lack of Sirt7 (show SIRT7 Proteins) is associated with reduced recruitment of DNMT1 and Sirt1 (show SIRT1 Proteins) at rRNA genes leading to hyperacetylation of histones, reduced DNA methylation (show HELLS Proteins), fragmentation of the nucleolar structure and loss of rDNA repeats leading to anincreased spontaneous immortalization of primary mouse embryonic fibroblasts.
The lethal Ogden syndrome-associated mutation of Naa10p disrupts its binding to the imprinting control region of H19 (show NCKAP1 Proteins) and Dnmt1 recruitment.
The T1505 is crucial on the DNA methylation (show HELLS Proteins) activity of DNMT1 through stabilizing its structure during ongoing round of DNA methylation (show HELLS Proteins).
During neurogenesis, cortical neurons became protected from S-phase Chk1 (show CHEK1 Proteins) pathway activation by the DNA methyltransferase Dnmt1, and underwent cell death after S-phase progression.
reciprocal regulation between miR (show MLXIP Proteins)-148a/152 and DNMT1 in foam cells
indispensable role of DNMT1-mediated epigenetic regulation in postnatal liver growth and regeneration
SETDB1 (show SETDB1 Proteins) maintains silencing of intracisternal A particle, but in the absence of DNMT1, prolonged binding of NP95 (show UHRF1 Proteins) to hemimethylated DNA transiently disrupts SETDB1 (show SETDB1 Proteins)-dependent H3K9me3 deposition.
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
DNA (cytosine-5)-methyltransferase 1
, CXXC-type zinc finger protein 9
, DNA MTase HsaI
, DNA methyltransferase HsaI
, DNA methyltransferase 1
, DNA (cytosine 5 ) methyltransferase 1
, DNA methyltransferase (cytosine 5 ) methyltransferase
, DNA methyltransferase b
, DNA MTase RnoIP
, DNA methyltransferase (cytosine-5) 1
, DNA methyltransferase I
, DNA MTase GgaI
, DNA MeTase
, DNA methyltransferase GgaI
, DNA MTase MmuI
, DNA methyltransferase MmuI