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DNA (Cytosine-5-)-Methyltransferase 3 beta Proteins (DNMT3B)

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNMT3B Antibodies (120) and DNMT3B Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DNMT3B 1789 Q9UBC3
Rat DNMT3B DNMT3B 444985  
DNMT3B 13436 O88509
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Top DNMT3B Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days

DNMT3B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Top referenced DNMT3B Proteins

  1. Human DNMT3B Protein expressed in HEK-293 Cells - ABIN2719618 : Cree, Fredericks, Miller, Pearce, Filichev, Fee, Kennedy: DNA G-quadruplexes show strong interaction with DNA methyltransferases in vitro. in FEBS letters 2016 (PubMed)

More Proteins for DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) Interaction Partners

Zebrafish DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) interaction partners

  1. dnmt7 specifically methylates no tail gene in the genome

Horse (Equine) DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) interaction partners

  1. Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (show HELLS Proteins) content are rather a function of time, and not a genetic component.

Human DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) interaction partners

  1. This condensed chromatin structure is associated with binding of DNMT3B and decreased occupancy of OCT1 transcription factor at MAML2 enhancer, suggesting a role of DNMT3B in increasing methylation of MAML2 after stilbenoid treatment.

  2. show that heterozygous mutations in DNA methyltransferase 3B (DNMT3B) are a likely cause of D4Z4 derepression associated with low levels of DUX4 expression

  3. The de novo methyltransferases DNMT3A (show DNMT3A Proteins) and 3B play a vital role in methylating the genome of the developing embryo in regions devoid of methylation marks.These observations suggest a potential interaction of G-quadruplexes with the DNA methylation (show HELLS Proteins) machinery, which may be of epigenetic and biological significance

  4. 149C>T and -2437T>A DNMT3B polymorphisms are not correlated with lung cancer risk among Chinese population nor the haplotype of them.

  5. DNMT1 (show DNMT1 Proteins), DNMT3A (show DNMT3A Proteins) and DNMT3B are highly expressed in human medulloblastoma samples

  6. The DNMT3A (show DNMT3A Proteins) -448A > G polymorphism may be a novel functional SNP and contribute to its genetic susceptibility to spontaneous abortion in Chinese women, and ART may not affect the distribution of -448A > G in pregnancy loss and normal pregnancy. The observed TT genotype of DMNT3B suggests that this is the predominant genotype of this population

  7. Significant upregulation of DNMT1 (show DNMT1 Proteins), DNMT3A (show DNMT3A Proteins), and DNMT3B expression was found in para-carcinoma tissues, compared with the histopathologically unchanged tissues furthermore, distinguishable expression profiling was observed of target miRNAs in tissues with different distance

  8. A potential role of rs2424913 (DNMT3B) and rs2228611 (DNMT1 (show DNMT1 Proteins)) in autoimmune thyroid diseases (AITD) susceptibility and identified novel gene-gene/gene-sex interactions in AITD. This may highlight sex and genes of DNMTs family as contributors to the pathogenesis of AITD.

  9. miR (show MLXIP Proteins)-29b was negatively correlated with DNMT3A (show DNMT3A Proteins)/3B expression at the cellular/histological levels.

  10. mRNA and protein expression levels of DNMT3b were upregulated in genotype 1b and 3a HCV-infected hepatocellular carcinoma patients as compared to control. DNMT3b mRNA levels did not change in genotypes 2a, 3, and 4, but were upregulated at the protein level by genotype 1b, 2a, and 3a. No differences were seen for genotypes 5 and 7.

Pig (Porcine) DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) interaction partners

  1. The epiblast expressed epithelial markers, MUC1 (show MUC1 Proteins) and E-CADHERIN (show CDH1 Proteins), and the pluripotency markers, DNMT3B and CRIPTO (show TDGF1 Proteins).

Cow (Bovine) DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) interaction partners

  1. Developmental changes in expression of DNMT3B are indicative of a possible role in changes in methylation in cattle.

  2. The expression levels of DNMT3a (show DNMT3A Proteins) and DNMT3b were associated with several beef quality traits.

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) interaction partners

  1. Mechanical stimulation regulates osteoblastic genes expression via direct regulation of Dnmt3b.

  2. a miR (show MLXIP Proteins)-125b-DNMT3b-p53 (show TP53 Proteins) signal pathway may exist in the vascular smooth muscle cells proliferation induced by homocysteine.

  3. miR-29a mimic transfection lowered collagen 1alpha1, DNMT1, DNMT3b and SET1A expression in hepatic stellate cells.

  4. Loss of DNMT3B results in hypomethylation of the miR-196b promoter and increased miR-196b expression, which directly targets the mTORC2 component Rictor.

  5. The findings define PRMT7 (show PRMT7 Proteins) as a regulator of the DNMT3b/p21 axis required to maintain muscle stem cell regenerative capacity.

  6. These results demonstrate that Dnmt1 (show DNMT1 Proteins) and Dnmt3b cooperate to maintain DNA methylation (show HELLS Proteins) and genomic integrity in the intestinal epithelium.

  7. Downregulation of DNMT3B, one of the targets identified using this method, radiosensitizes cancer cells by disturbing multiple DNA damage responses.

  8. High levels of Dnmt3b expression prolong leukemia latency.

  9. The expression of DNMT1 and DNMT3b was decreased at 1 mT, and 50 Hz ELF-EMF can increase the expression...the alterations of genome-wide methylation and DNMTs expression may play an important role in the biological effects of 50 Hz ELF-EMF exposure

  10. DKO cardiomyocytes showed virtual absence of targeted Dnmt3a (show DNMT3A Proteins) and Dnmt3b mRNA transcripts.

DNMT3B Protein Profile

Protein Summary

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.

Gene names and symbols associated with DNMT3B

  • DNA (cytosine-5-)-methyltransferase 4 (dnmt4)
  • DNA (cytosine-5-)-methyltransferase 3 beta (DNMT3B)
  • DNA (cytosine-5-)-methyltransferase 3 beta (LOC100218113)
  • DNA methyltransferase 3B (dnmt3b)
  • DNA (cytosine-5-)-methyltransferase 3 beta (dnmt3b)
  • DNA (cytosine-5-)-methyltransferase 3 beta (Dnmt3b)
  • DNA methyltransferase 3B (Dnmt3b)
  • cb91 protein
  • cb633 protein
  • DNMT3B protein
  • dnmt3bl protein
  • dnmt7 protein
  • ICF protein
  • ICF1 protein
  • LOC100218113 protein
  • M.HsaIIIB protein
  • MmuIIIB protein
  • sb:cb91 protein
  • wu:fb16h07 protein

Protein level used designations for DNMT3B

DNA (cytosine-5)-methyltransferase 3B , DNA (cytosine-5-)-methyltransferase 3 beta , DNA cytosine-5 methyltransferase 3 beta , DNA (cytosine-5)-methyltransferase 3B-like , DNA methyl transferase beta , DNA methyltransferase 3B , DNA MTase HsaIIIB , DNA methyltransferase HsaIIIB , DNA (cytosine-5-)-methyltransferase 3 beta, like , DNA (cytosine-5-)-methyltransferase 7 , fb16h07 , DNA MTase MmuIIIB , DNA methyltransferase MmuIIIB

317744 Danio rerio
458174 Pan troglodytes
711553 Macaca mulatta
100053900 Equus caballus
100218113 Taeniopygia guttata
100412936 Callithrix jacchus
100459992 Pongo abelii
100466728 Ailuropoda melanoleuca
100500777 Ovis aries
100598378 Nomascus leucogenys
100528060 Anolis carolinensis
1789 Homo sapiens
321084 Danio rerio
419287 Gallus gallus
100302109 Sus scrofa
353354 Bos taurus
444985 Rattus norvegicus
13436 Mus musculus
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